scholarly journals The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 817 ◽  
Author(s):  
Jacob M Riveron ◽  
Sulaiman S Ibrahim ◽  
Emmanuel Chanda ◽  
Themba Mzilahowa ◽  
Nelson Cuamba ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Cytochrome P450 Gene ◽  
P450 Gene

scholarly journals The Cytochrome P450 gene CYP6P12 confers pyrethroid resistance in kdr-free Malaysian populations of the dengue vector Aedes albopictus

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Intan H. Ishak ◽  
Jacob M. Riveron ◽  
Sulaiman S. Ibrahim ◽  
Rob Stott ◽  
Joshua Longbottom ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aedes Albopictus ◽  
Pyrethroid Resistance ◽  
Dengue Vector ◽  
Cytochrome P450 Gene ◽  
P450 Gene

scholarly journals Age-related pyrethroid resistance is not a function of P450 gene expression in the major African malaria vector, Anopheles funestus (Diptera: Culicidae)

2011 ◽  
Vol 10 (4) ◽  
pp. 3220-3229 ◽  
Author(s):  
R.N. Christian ◽  
T.S. Matambo ◽  
B.L. Spillings ◽  
B.D. Brooke ◽  
M. Coetzee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
P450 Gene ◽  
Age Related

The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa

2021 ◽  
Vol 138 ◽  
pp. 103647 ◽  
Author(s):  
Amelie N.R. Wamba ◽  
Sulaiman S. Ibrahim ◽  
Michael O. Kusimo ◽  
Abdullahi Muhammad ◽  
Leon M.J. Mugenzi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Central Africa ◽  
Major Malaria Vector

scholarly journals Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique

2019 ◽  
Vol 220 (3) ◽  
pp. 467-475 ◽  
Author(s):  
Jacob M Riveron ◽  
Silvie Huijben ◽  
Williams Tchapga ◽  
Magellan Tchouakui ◽  
Murielle J Wondji ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Resistance Mechanisms ◽  
Piperonyl Butoxide ◽  
Insecticide Treated Nets ◽  
Molecular Analyses ◽  
Cytochrome P450 Genes ◽  
High Degree ◽  
Long Lasting Insecticidal Nets

Abstract Background Insecticide resistance poses a serious threat to insecticide-based interventions in Africa. There is a fear that resistance escalation could jeopardize malaria control efforts. Monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict consequences of resistance. Methods The resistance levels of an Anopheles funestus population from Palmeira, southern Mozambique, were characterized and their impact on the efficacy of various insecticide-treated nets established. Results A dramatic loss of efficacy of all long-lasting insecticidal nets (LLINs), including piperonyl butoxide (PBO)–based nets (Olyset Plus), was observed. This An. funestus population consistently (2016, 2017, and 2018) exhibited a high degree of pyrethroid resistance. Molecular analyses revealed that this resistance escalation was associated with a massive overexpression of the duplicated cytochrome P450 genes CYP6P9a and CYP6P9b, and also the fixation of the resistance CYP6P9a_R allele in this population in 2016 (100%) in contrast to 2002 (5%). However, the low recovery of susceptibility after PBO synergist assay suggests that other resistance mechanisms could be involved. Conclusions The loss of efficacy of pyrethroid-based LLINs with and without PBO is a concern for the effectiveness of insecticide-based interventions, and action should be taken to prevent the spread of such super-resistance.

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