scholarly journals A chromosome-scale assembly of the major African malaria vector Anopheles funestus

GigaScience ◽  
2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Jay Ghurye ◽  
Sergey Koren ◽  
Scott T Small ◽  
Seth Redmond ◽  
Paul Howell ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus

scholarly journals Evidence of a multiple insecticide resistance in the malaria vector Anopheles funestus in South West Nigeria

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Rousseau J. Djouaka ◽  
Seun M. Atoyebi ◽  
Genevieve M. Tchigossou ◽  
Jacob M. Riveron ◽  
Helen Irving ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
South West

scholarly journals Exposure to the insecticide-treated bednet PermaNet 2.0 reduces the longevity of the wild African malaria vector Anopheles funestus but GSTe2-resistant mosquitoes live longer

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213949 ◽  
Author(s):  
Ange Tchakounte ◽  
Magellan Tchouakui ◽  
Chiang Mu-Chun ◽  
Williams Tchapga ◽  
Edmond Kopia ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus

scholarly journals A marker of glutathione S-transferase-mediated resistance to insecticides is associated with higher Plasmodium infection in the African malaria vector Anopheles funestus

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Magellan Tchouakui ◽  
Mu-Chun Chiang ◽  
Cyrille Ndo ◽  
Carine K. Kuicheu ◽  
Nathalie Amvongo-Adjia ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Anopheles Funestus ◽  
Plasmodium Infection ◽  
Glutathione S Transferase

Isolation of polymorphic microsatellite loci from the malaria vector Anopheles funestus

2000 ◽  
Vol 9 (4) ◽  
pp. 490-492 ◽  
Author(s):  
S. P. Sinkins ◽  
B. J. Hackett ◽  
C. Costantini ◽  
J. Vulule ◽  
Y-Y. Ling ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Microsatellite Loci ◽  
Anopheles Funestus ◽  
Polymorphic Microsatellite

scholarly journals Cytochrome P450 metabolic resistance (CYP6P9a) to pyrethroids imposes a fitness cost in the major African malaria vector Anopheles funestus

Heredity ◽  
2020 ◽  
Vol 124 (5) ◽  
pp. 621-632 ◽  
Author(s):  
Magellan Tchouakui ◽  
Jacob Riveron Miranda ◽  
Leon M. J. Mugenzi ◽  
Doumani Djonabaye ◽  
Murielle J. Wondji ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Management Strategy ◽  
Management Strategies ◽  
Resistance Management ◽  
Anopheles Funestus ◽  
Fitness Cost ◽  
Malaria Vectors ◽  
Hybrid Strain ◽  
Metabolic Resistance ◽  
The Impact

Abstract Metabolic resistance threatens the sustainability of pyrethroid-based malaria control interventions. Elucidating the fitness cost and potential reversal of metabolic resistance is crucial to design suitable resistance management strategies. Here, we deciphered the fitness cost associated with the CYP6P9a (P450-mediated metabolic resistance) in the major African malaria vector Anopheles funestus. Reciprocal crosses were performed between a pyrethroid susceptible (FANG) and resistant (FUMOZ-R) laboratory strains and the hybrid strains showed intermediate resistance. Genotyping the CYP6P9a-R resistance allele in oviposited females revealed that CYP6P9a negatively impacts the fecundity as homozygote susceptible mosquitoes (CYP6P9a-SS) lay more eggs than heterozygote (OR = 2.04: P = 0.01) and homozygote resistant mosquitoes. CYP6P9a also imposes a significant fitness cost on the larval development as homozygote resistant larvae (CYP6P9a-RR) developed significantly slower than heterozygote and homozygote susceptible mosquitoes (χ2 = 11.2; P = 0.0008). This fitness cost was further supported by the late pupation of homozygote resistant than susceptible mosquitoes (OR = 2.50; P < 0.01). However, CYP6P9a does not impact the longevity as no difference was observed in the life span of mosquitoes with different genotypes (χ2 = 1.6; P = 0.9). In this hybrid strain, a significant decrease of the resistant CYP6P9a-RR genotype was observed after ten generations (χ2 = 6.6; P = 0.01) suggesting a reversal of P450-based resistance in the absence of selection. This study shows that the P450-mediated metabolic resistance imposes a high fitness cost in malaria vectors supporting that a resistance management strategy based on rotation could help mitigate the impact of such resistance.

Rangewide population genetic structure of the African malaria vector Anopheles funestus

2005 ◽  
Vol 14 (14) ◽  
pp. 4235-4248 ◽  
Author(s):  
A. P. MICHEL ◽  
M. J. INGRASCI ◽  
B. J. SCHEMERHORN ◽  
M. KERN ◽  
G. GOFF ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Malaria Vector ◽  
Population Genetic Structure ◽  
Population Genetic ◽  
Anopheles Funestus

scholarly journals Cuticle thickening associated with pyrethroid resistance in the major malaria vector Anopheles funestus

2010 ◽  
Vol 3 (1) ◽  
pp. 67 ◽  
Author(s):  
O R Wood ◽  
S Hanrahan ◽  
M Coetzee ◽  
L L Koekemoer ◽  
B D Brooke
Keyword(s):  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Major Malaria Vector

Population structure of the malaria vector Anopheles funestus in Senegal based on microsatellite and cytogenetic data

2004 ◽  
Vol 13 (3) ◽  
pp. 251-258 ◽  
Author(s):  
A. Cohuet ◽  
I. Dia ◽  
F. Simard ◽  
M. Raymond ◽  
D. Fontenille
Keyword(s):  
Population Structure ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
Cytogenetic Data
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