Effect of Chronic Neutralization of Endogenous FSH on Testicular Function in the Adult Male Bonnet Monkey – Assessment Using Biochemical Parameters

ABSTRACT In adult male rats subcutaneous injections of 50 μg dienoestrol [3,4-bis (p-hydroxyphenyl)-hexa-2,4-diene] diacetate, given twice weekly, produced an inhibition of spermiogenesis and sexual behaviour resulting in total sterility. By one intratesticular implantation of 3 mg testosterone these alterations could be prevented and even rechanged in spite of continued oestrogen administration. These results prove an important direct influence of testosterone on the generative testicular function.

Download Full-text

Effect of α2u-globulin on serum concentration of gonadotrophins and testicular activity in oestrogen-treated rats

Journal of Endocrinology ◽

10.1677/joe.0.0960321 ◽

1983 ◽

Vol 96 (2) ◽

pp. 321-327 ◽

Cited By ~ 10

Author(s):

N. M. Biswas ◽

P. K. Ghosh ◽

K. K. Ghosh ◽

O. W. Neuhaus

Keyword(s):

Serum Concentration ◽

Adult Male ◽

Serum Levels ◽

Hydroxysteroid Dehydrogenase ◽

Organ Weight ◽

Male Rats ◽

Testicular Function ◽

Accessory Sex Organs ◽

Testosterone Synthesis

Adult male rats were given injections of oestradiol-17β (50 μg/100 g body wt per day) for 7 days. When they were killed 14 days after the last injection, serum levels of gonadotrophins and testosterone and weights of accessory sex organs were less, testicular 17β-hydroxysteroid dehydrogenase 17β-HSD activity was suppressed and spermatogenesis was inhibited. Administration of α2u-globulin (1·5 mg/day) for 14 days to oestrogen-treated rats and for 10 days to control rats resulted in increased concentrations of gonadotrophins and testosterone in the serum. Accessory sex organ weight and spermatogenesis appeared to be normal while 17β-HSD activity increased in oestrogen-treated rats after treatment with α2u-globulin. It was concluded that α2u-globulin has an effect on testicular function in oestrogenized rats by inducing gonadotrophin and testosterone synthesis.

Download Full-text

Normal hematological and plasma biochemical parameters of the captive bonnet monkey (Maccaca radiata)

Primates ◽

10.1007/bf02557725 ◽

1998 ◽

Vol 39 (2) ◽

pp. 127-134 ◽

Cited By ~ 9

Author(s):

S. G. Ramachandra ◽

V. Ramesh ◽

H. N. Krishnamurthy ◽

N. Ravindranath ◽

K. Taranatha Shetty

Keyword(s):

Biochemical Parameters ◽

Bonnet Monkey

Download Full-text

Effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey (Macaca radiata):

Andrologia ◽

10.1111/j.1439-0272.1990.tb01975.x ◽

2009 ◽

Vol 22 (3) ◽

pp. 251-259 ◽

Cited By ~ 3

Author(s):

A. Jagannadha Rao ◽

C. S. Sheela Rani ◽

N. Ravindranath ◽

N. R. Moudgal

Keyword(s):

Adult Male ◽

Prolactin Secretion ◽

Macaca Radiata ◽

Testosterone Production ◽

Bonnet Monkey

Download Full-text

Pituitary and gonadal function in pubertal and adult male rabbits with pseudohermaphroditism secondary to immunization of mothers against testosterone

Acta Endocrinologica ◽

10.1530/acta.0.1070550 ◽

1984 ◽

Vol 107 (4) ◽

pp. 550-555

Author(s):

G. Veyssière ◽

M. Berger ◽

Ch. Jean-Faucher ◽

M. de Turckheim ◽

Cl. Jean

Keyword(s):

Adult Male ◽

Sexual Behaviour ◽

Sexual Maturation ◽

Perinatal Period ◽

Developmental Pattern ◽

Plasma Testosterone ◽

Testicular Function ◽

Gonadal Function ◽

Central Effects ◽

Male Sexual Behaviour

Abstract. Pituitary and testicular function was studied in pubertal and adult rabbits with pseudohermaphroditism secondary to immunization of mothers against testosterone. Circulating testosterone, LH and FSH levels showed a developmental pattern during sexual maturation, similar to that observed in controls. Plasma FSH levels were elevated in male pseudohermaphrodites despite normal plasma testosterone concentrations. Fighting, male sexual behaviour and coitus occurred normally as in controls. The testicular response to endogenous elevated LH levels and the pituitary LH and FSH responses to LRH injection and to castration were similar in affected males and in controls. These observations suggest that inhibition of the central effects of androgens during the embryonic and perinatal period has little or no effect on the differentiation and maturation of the hypothalamo-pituitary-testicular axis in rabbit.

Download Full-text