Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus

2006 ◽  
Vol 62 (4) ◽  
pp. 1132-1143 ◽  
Author(s):  
Adam Belley ◽  
Mario Callejo ◽  
Francis Arhin ◽  
Mohammed Dehbi ◽  
Ibtihal Fadhil ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Dna Replication ◽  
Sliding Clamp ◽  
Replication Arrest ◽  
Replicase Proteins

scholarly journals DNA REPLICATION ARREST AND P53-DEPENDENT AND P53-INDEPENDENT CELL DEATH PATHWAYS IN XERODERMA PIGMENTOSUM VARIANT CELLS

2001 ◽  
Vol 1 (S3) ◽  
pp. 60-60
Author(s):  
James E. Cleaver ◽  
Eileen Crowley ◽  
Mohammed Kashani-Sabet ◽  
Charles L. Limoli
Keyword(s):  
Cell Death ◽  
Dna Replication ◽  
Xeroderma Pigmentosum ◽  
Replication Arrest ◽  
Cell Death Pathways

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1

2001 ◽  
Vol 3 (11) ◽  
pp. 966-972 ◽  
Author(s):  
Katsunori Tanaka ◽  
Paul Russell
Keyword(s):  
Dna Replication ◽  
Checkpoint Kinase ◽  
Replication Arrest

scholarly journals KSHV-encoded vCyclin can modulate HIF1α levels to promote DNA replication in hypoxia

2020 ◽  
Author(s):  
Rajnish Kumar Singh ◽  
Yonggang Pei ◽  
Zachary L Lamplugh ◽  
Kunfeng Sun ◽  
Yan Yuan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Division ◽  
Dna Replication ◽  
Cancer Cells ◽  
Adaptive Response ◽  
Transcriptional Activity ◽  
Metabolic Reprogramming ◽  
Kshv Infection ◽  
Replication Arrest ◽  
Infected Cells

AbstractThe cellular adaptive response to hypoxia, mediated by high HIF1α levels includes metabolic reprogramming, restricted DNA replication and cell division. In contrast to healthy cells, the genome of cancer cells, and Kaposi’s sarcoma associated herpesvirus (KSHV) infected cells maintains replication in hypoxia. We show that KSHV infection, despite promoting expression of HIF1α in normoxia, can also restricts transcriptional activity, and promoted its degradation in hypoxia. KSHV-encoded vCyclin, expressed in hypoxia, mediated HIF1a cytosolic translocation, and its degradation through a non-canonical lysosomal pathway. Attenuation of HIF1α levels by vCyclin allowed cells to bypass the block to DNA replication and cell proliferation in the hypoxia. These results demonstrated that KSHV utilizes a unique strategy to balance HIF1α levels to overcome replication arrest and induction of the oncogenic phenotype, which are dependent on the levels of oxygen in the microenvironment.

DNA replication in bacteriophage-infected Staphylococcus aureus.

1977 ◽  
Vol 24 (3) ◽  
pp. 768-774 ◽  
Author(s):  
M H Ubelaker ◽  
E D Rosenblum
Keyword(s):  
Staphylococcus Aureus ◽  
Dna Replication

scholarly journals Cyclic Peptide Inhibitors of the β-Sliding Clamp in Staphylococcus aureus

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e72273 ◽  
Author(s):  
Susanne Kjelstrup ◽  
Paula Melo Paulon Hansen ◽  
Line E. Thomsen ◽  
Paul Robert Hansen ◽  
Anders Løbner-Olesen
Keyword(s):  
Staphylococcus Aureus ◽  
Cyclic Peptide ◽  
Peptide Inhibitors ◽  
Sliding Clamp
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