Resistance to liver fluke infection in the natural sheep host is correlated with a type-1 cytokine response

2011 ◽  
Vol 33 (9) ◽  
pp. 495-505 ◽  
Author(s):  
J. PLEASANCE ◽  
E. WIEDOSARI ◽  
H. W. RAADSMA ◽  
E. MEEUSEN ◽  
D. PIEDRAFITA
Life Sciences ◽  
2021 ◽  
pp. 119494
Author(s):  
Viatcheslav A. Mordvinov ◽  
Galina A. Minkova ◽  
Anna V. Kovner ◽  
Dmitriy V. Ponomarev ◽  
Maria N. Lvova ◽  
...  

2021 ◽  
pp. 102382
Author(s):  
Yi-Chen Wang ◽  
Carl Grundy-Warr ◽  
Jutamas Namsanor ◽  
Miles Kenney-Lazar ◽  
Charlotte Jie Yi Tang ◽  
...  

2019 ◽  
Vol 7 ◽  
pp. 205031211984020 ◽  
Author(s):  
Woragon Wichaiyo ◽  
Wirat Parnsila ◽  
Wisit Chaveepojnkamjorn ◽  
Banchob Sripa

Background: Liver fluke disease caused by Opisthorchis viverrini remains a major public health problem with its crucial risk factors caused by some individual habits or false beliefs among the people in northeastern Thailand concerning the consumption of raw fish meat dishes. Objectives: This study explores the predictive risk factors for the infection of liver fluke disease. Methods: The sample consisted of 400 people aged 30 years and above in Thanya sub-district, Kamalasai district, Kalasin province. A cross-sectional analytic study, using the χ2 test, odds ratio and 95% confidence interval, was used to find the influence of each variable, along with the use of multiple logistic regression (p = 0.05). A questionnaire form was used as the research instrument. Results: Factors found in the results are as follows: households with a cat were 7.00 times more at risk than households without a cat; eating raw fish dishes prepared by themselves increases the risk of infection by 2.58 times; eating raw fish dishes prepared by family members increases the risk by 4.74 times; and raw fish dishes bought from a community market increases the risk by 2.33 times. Conclusion: A campaign should be launched to educate people not to eat raw or undercooked fish dishes, but to fully cook fish dishes before eating, as the food is still delicious, but also safe, healthy, and free from liver fluke infection.


2011 ◽  
Vol 31 (4) ◽  
pp. 393-400 ◽  
Author(s):  
Adam J. Karpala ◽  
John Bingham ◽  
Karel A. Schat ◽  
Li-Mei Chen ◽  
Ruben O. Donis ◽  
...  

2002 ◽  
Vol 76 (19) ◽  
pp. 9657-9663 ◽  
Author(s):  
Palanivel Velupillai ◽  
John P. Carroll ◽  
Thomas L. Benjamin

ABSTRACT Mice of the PERA/Ei strain (PE mice) are highly susceptible to tumor induction by polyomavirus and transmit their susceptibility in a dominant manner in crosses with resistant C57BR/cdJ mice (BR mice). BR mice respond to polyomavirus infection with a type 1 cytokine response and develop effective cell-mediated immunity to the virus-induced tumors. By enumerating virus-specific CD8+ T cells and measuring cytokine responses, we show that the susceptibility of PE mice is due to the absence of a type 1 cytokine response and a concomitant failure to sustain virus-specific cytotoxic T lymphocytes. (PE × BR)F1 mice showed an initial type 1 response that became skewed toward type 2. Culture supernatants of splenocytes from infected PE mice stimulated in vitro contained high levels of interleukin-10 and no detectable gamma interferon, while those from BR mice showed the opposite pattern. Differences in the innate immune response to polyomavirus by antigen-presenting cells in PE mice and BR mice led to polarization of T-cell cytokine responses. Adherent cells from spleens of infected BR mice produced high levels of interleukin-12, while those from infected PE and F1 mice produced predominantly interleukin-10. PE and F1 mice infected by polyomavirus responded with increases in antigen-presenting cells expressing B7.2 costimulatory molecules, whereas BR mice responded with increased expression of B7.1. Administration of recombinant interleukin-12 along with virus resulted in partial protection of PE mice and provided complete protection against tumor development in F1 animals.


Vox Sanguinis ◽  
1970 ◽  
Vol 18 (2) ◽  
pp. 188-189
Author(s):  
B. Bevan ◽  
W. Hammond ◽  
R.L. Clarke

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