A site-preparation study installed in 1959 in Fayette County, Alabama, U.S.A., provides data to evaluate long-term effects of varying densities of hardwood on loblolly pine (Pinustaeda L.) plantation growth, yield, and stand structure. Six treatments (hand girdle; bulldoze scarification; herbicide applied to axe frill, chain frill, and with an injector; and an untreated check) were installed as a randomized complete block with five replications. Periodic measurements of pine and hardwood size and density show that higher hardwood densities existing early in the pine plantation had a substantial negative effect on loblolly pine survival and basal area yield, with the bulldoze and herbicide treatments having less hardwood and higher survival and stand basal area. Pine total height and diameter at breast height were reduced by increasing hardwood density early in the life of the plantation, but size of surviving trees differed little among treatments at later ages, except on plots where most pine trees were suppressed by hardwoods. Strong relationships between pine basal area per hectare at age 27 and both number of hardwood stems at age 3 and percentage of stand basal area in hardwood at age 6 were noted. These relationships indicate promise for predicting long-term growth and yield of loblolly pine plantations from early measures of hardwood interference.