CUTANEOUS LUPUS ERYTHEMATOSUS: DIRECT IMMUNOFLUORESCENCE AND EPIDERMAL BASAL MEMBRANE STUDY

A 23-year-old man developed drug-induced chronic cutaneous lupus erythematosus 8 months after isoniazid (INH) therapy for pulmonary tuberculosis. Diagnosis was based on clinical aspects (discoid lesions on the face, erythema, photosensitivity, hyperpigmentation), histopathological examination, along with direct immunofluorescence examination (DIF), the absence of systemic involvement and the routine laboratory parameters, which registered all within normal range. Hydroxychloroquine therapy associated to photo protection and emollients determined the clear up of the facial eruption within six months. Transient residual hyperpigmentation could be noticed 2 months after discontinuation of the treatment. This case illustrates a rare form of drug-induced chronic cutaneous lupus erythematosus developed 2 months after withdrawal of antituberculosis therapy, with excellent results with hydroxychloroquine.NJDVL Vol. 13, No. 1, 2015 Page: 52-56

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Adult-onset linear discoid lupus erythematosus on the forehead mimicking en coup de sabre: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-019-2249-7 ◽

2019 ◽

Vol 13 (1) ◽

Cited By ~ 1

Author(s):

Sasipaka Sindhusen ◽

Kumutnart Chanprapaph ◽

Suthinee Rutnin

Keyword(s):

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Direct Immunofluorescence ◽

Discoid Lupus Erythematosus ◽

Adult Onset ◽

Thai Patient ◽

Case Presentation ◽

Lines Of Blaschko ◽

Children And Young Adults ◽

Cutaneous Lupus

Abstract Background Linear cutaneous lupus erythematosus (LE) is an unusual form of LE-specific cutaneous condition, occurring in children and young adults. Due to its rarity, the diagnosis of linear cutaneous LE can be difficult and facial lesions can resemble linear morphea or en coup de sabre. Differential diagnosis of similar conditions along the lines of Blaschko must be differentiated from linear LE. Case presentation We report a case of linear discoid LE on the forehead of an adult female Thai patient mimicking en coup de sabre. The dermatoscopy, histopathology and direct immunofluorescence findings were consistent with chronic cutaneous LE. Conclusions As this patient demonstrated classic dermatoscopic features of LE, we emphasized that the diagnosis of linear cutaneous LE can be made by dermatoscopy. This is particularly beneficial for young self-conscious patients with facial lesions that are reluctant to perform skin biopsy.

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CUTANEOUS LUPUS ERYTHEMATOSUS: COMPARISON OF DIRECT IMMUNOFLUORESCENCE FINDINGS WITH HISTOPATHOLOGY

International Journal of Dermatology ◽

10.1111/j.1365-4362.1995.tb00615.x ◽

1995 ◽

Vol 34 (7) ◽

pp. 480-482 ◽

Cited By ~ 10

Author(s):

ABDUL RAOUF AL-SUWAID ◽

MYSORE NAGARAJ VENKATARAM ◽

SHIVAYOGI RUDRIAH BHUSHNURMATH

Keyword(s):

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Direct Immunofluorescence ◽

Cutaneous Lupus

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Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma

BMJ Case Reports ◽

10.1136/bcr-2019-231152 ◽

2019 ◽

Vol 12 (10) ◽

pp. e231152

Author(s):

Luís Santiago ◽

Rosa Mascarenhas ◽

Óscar Tellechea ◽

Margarida Gonçalo

Keyword(s):

Toxic Epidermal Necrolysis ◽

Lung Carcinoma ◽

Lupus Erythematosus ◽

Cutaneous Lupus Erythematosus ◽

Skin Lesions ◽

Direct Immunofluorescence ◽

Bullous Eruption ◽

Culprit Drug ◽

Positive Direct ◽

Cutaneous Lupus

Specific vesiculobullous skin lesions in lupus erythematosus (LE) are rare and must be differentiated from toxic epidermal necrolysis (TEN), TEN-like dermatoses and other vesiculobullous conditions. We report a patient with typical subacute cutaneous lupus erythematous that progressed with large sheet-like areas of epidermal detachment and Nikolsky sign resembling TEN. She had a serological profile suggestive of underlying connective tissue disease, histological findings of interface dermatitis with a lymphocytic infiltrate, positive direct immunofluorescence, resolution with immunomodulation and lack of a culprit drug, features observed in TEN-like cutaneous lupus erythematous. Furthermore, she was diagnosed with lung carcinoma, an association that has been previously reported. Differentiating a bullous eruption in the context of pre-existing LE remains difficult requiring a thorough analysis of clinical and histopathological data.

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