The effects of oral zinc sulphate during radiotherapy on anti-oxidant enzyme activities in patients with head and neck cancer: A prospective, randomised, placebo-controlled study

OBJECTIVE: Description of a new noninvasive method for the evaluation of tissue oxygenation in head and neck cancer. STUDY DESIGN AND SETTING: Prospective nonrandomized controlled study in an academic medical center on 20 patients with neck metastases of head and neck cancer. Metastases were investigated using color duplex sonography and pO2 histography. The vascularization in sonography was quantitatively evaluated by color pixel density and compared to the pO2 values of the same nodes. RESULTS: The correlation between vascularization and flow velocity was 0.71. For the mean/median pO2-values and for the pO2 readings < 10.0 mmHg correlations were r = 0.65/0.76 and 0.71. CONCLUSION: This sonographic method allows a safe and reliable evaluation of oxygenation in metastases of head and neck cancer. SIGNIFICANCE: The new approach is an alternative to pO2 histography and may play a future role in the planning of radiotherapy in the neck. (Otolaryngol Head Neck Surg 2005;132:765-9.)

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Voice Outcomes Following Head-Lift Exercises in Head and Neck Cancer: A Randomized Controlled Study

Journal of Voice ◽

10.1016/j.jvoice.2020.12.015 ◽

2021 ◽

Author(s):

Hedvig Eriksson ◽

Lisa Tuomi ◽

Caterina Finizia

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Randomized Controlled Study ◽

Controlled Study ◽

Randomized Controlled

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Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers

Oncology Reviews ◽

10.4081/oncol.2015.290 ◽

2015 ◽

Cited By ~ 2

Author(s):

Ritujith Jayakrishnan ◽

Kenneth Chang ◽

Gamze Ugurluer ◽

Robert C. Miller ◽

Terence T. Sio

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Tricyclic Antidepressant ◽

Controlled Study ◽

Adverse Side Effects ◽

Oral Cancers ◽

Oncologic Treatment

Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a placebo-controlled crossover study (Leenstra and Miller et al.). Currently, a placebo-controlled study (Sio and Miller et al.) using doxepin for esophagitis pain caused by RT to the thorax is underway. Doxepin will also be further compared with magic mouthwash and a placebo solution in a three-arm trial (Miller and Sio et al.) with head and neck cancer patients with OM pain caused by RT. Doxepin may represent a new standard for treating RT-induced OM pain in the future.

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A phase III double-blind randomized placebo controlled study of porfiromycin and radiation therapy in patients with head and neck cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(02)03184-x ◽

2002 ◽

Vol 54 (2) ◽

pp. 74

Author(s):

E.F Lartigau ◽

J Giralt ◽

P Glassman ◽

A Lawton ◽

R von Roemeling

Keyword(s):

Radiation Therapy ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Phase Iii ◽

Controlled Study ◽

Double Blind

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A phase III randomized clinical trial of diclofenac versus tramadol for mucositis-related pain in head and neck cancer patients undergoing concurrent chemoradiation.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e24124 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e24124-e24124

Author(s):

Sachin Babanrao Dhumal ◽

Vanita Noronha ◽

Vijay Maruti Patil ◽

Amit Joshi ◽

Nandini Sharrel Menon ◽

...

Keyword(s):

Clinical Trial ◽

Head And Neck Cancer ◽

Adverse Events ◽

Head And Neck ◽

Renal Dysfunction ◽

Cancer Patients ◽

Neck Cancer ◽

Phase Iii ◽

Controlled Study ◽

Significant Difference

e24124 Background: Oral mucositis related pain during CTRT in head and neck cancers is a common problem. Unfortunately, in spite of it being common, there is limited evidence for selection of systemic analgesic in this situation. Hence, this study was designed to compare the analgesic effect of an NSAID (diclofenac) versus a weak opioid (tramadol). Methods: This was an open-label, parallel design, superiority randomized controlled study. In this study head and neck cancer patients undergoing radical or adjuvant chemoradiation, who had grade 1 or above mucositis (in accordance with CTCAE version 4.03) and had pain related to it were randomly assigned to either diclofenac or tramadol for mucositis related pain control. The primary endpoint was analgesia after the 1st dose. The secondary endpoints were the rate of change in analgesic within 1 week, adverse events, and quality of life. Results: 128 patients were randomized, 66 in diclofenac and 62 in tramadol arm. The median AUC for the diclofenac arm and the tramadol arm were 348.936 units (Range 113.64-1969.23) & 420.87 (101.97-1465.96) respectively (p = 0.05619). Five patients (8.1%) in the tramadol arm and 11 patients (16.7%) in the diclofenac arm required a change in analgesic within 1 week of starting the analgesic (p = 0.184). There was no statistically significant difference in any adverse events between the 2 arms. However, the rate of any grade of renal dysfunction was numerically higher in diclofenac arm (10.6% versus 4.8%, p = 0.326). Conclusions: In this phase 3 study, evaluating diclofenac and tramadol for Chemoradiation induced mucositis pain, the analgesic efficacy of both analgesics was found to be similar but diclofenac was associated with a higher rate of renal dysfunction. Clinical trial information: CTRI/2016/09/007302 .

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