Changes in Disposition Kinetics of Sulphadimidine in Response to Acute Regional Liver Damage in Sheep

1990 ◽  
Vol 37 (1-10) ◽  
pp. 787-794
Author(s):  
T. Argaw ◽  
H. Brugere
Keyword(s):  
Liver Damage ◽  
Disposition Kinetics ◽  
Kinetics Of

Disposition kinetics of cypermethrin and fenvalerate in black bengal lactating goats

1995 ◽  
Vol 45 (3) ◽  
pp. 215-219
Author(s):  
Tapan K. Mandal ◽  
Animesh K. Chakraborty ◽  
Anjan Bhattacharyya
Keyword(s):  
Disposition Kinetics ◽  
Lactating Goats ◽  
Kinetics Of

Disposition Kinetics of Disopyramide in Human Healthy Volunteers Described by an Open Three Compartment Model

1989 ◽  
Vol 64 (5) ◽  
pp. 412-416 ◽  
Author(s):  
Jan Bonde ◽  
Niels Melchior Jensen ◽  
Lars E. Pedersen ◽  
Helle R. Angelo ◽  
Seren N. Rasmussen ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Compartment Model ◽  
Disposition Kinetics ◽  
Three Compartment Model ◽  
Kinetics Of

Bioavailability and disposition kinetics of amoxicillin in neonatal foals

1988 ◽  
Vol 20 (2) ◽  
pp. 125-127 ◽  
Author(s):  
J. D. BAGGOT ◽  
DARIA N. LOVE ◽  
JENNIFER STEWART ◽  
J. RAUS
Keyword(s):  
Disposition Kinetics ◽  
Kinetics Of

Effect of induced surgical stress and acute renal failure on disposition kinetics of ceftizoxime in goats

2005 ◽  
Vol 37 (3) ◽  
pp. 186
Author(s):  
TK Mandal ◽  
RK Shakthidevan ◽  
KC Jha ◽  
SK Das ◽  
US Chatterjee ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Surgical Stress ◽  
Disposition Kinetics ◽  
Kinetics Of

Comparative plasma disposition kinetics of albendazole and its new benzimidazol prodrug in dog

2016 ◽  
Vol 74 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Z. Khalil ◽  
M. El Karbane ◽  
M.E.A. Faouzi ◽  
M. Ansar ◽  
M. Azougagh ◽  
...  
Keyword(s):  
Disposition Kinetics ◽  
Kinetics Of

scholarly journals Disposition kinetics of cefamandole during continuous ambulatory peritoneal dialysis.

1986 ◽  
Vol 29 (4) ◽  
pp. 649-653 ◽  
Author(s):  
M Bliss ◽  
M Mayersohn ◽  
T Arnold ◽  
J Logan ◽  
U F Michael ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Disposition Kinetics ◽  
Kinetics Of

scholarly journals Absorption and disposition kinetics of amoxicillin in normal human subjects.

1980 ◽  
Vol 17 (2) ◽  
pp. 199-202 ◽  
Author(s):  
A Arancibia ◽  
J Guttmann ◽  
G Gonzalez ◽  
C Gonzalez
Keyword(s):  
Human Subjects ◽  
Disposition Kinetics ◽  
Normal Human ◽  
Kinetics Of

Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate

2011 ◽  
Vol 300 (1) ◽  
pp. G130-G136 ◽  
Author(s):  
Michael S. Roberts ◽  
Xin Liu ◽  
Yuhong Zou ◽  
Gerhard A. Siebert ◽  
Ping Chang ◽  
...  
Keyword(s):  
Bile Salt ◽  
Mrna Expression ◽  
Rate Constant ◽  
Systemic Inflammation ◽  
Atp Content ◽  
Influx Rate ◽  
Hepatic Disposition ◽  
Disposition Kinetics ◽  
Bile Salt Transporters ◽  
Kinetics Of

It has been reported that the adjuvant-induced inflammation could affect drug metabolism in liver. Here we further investigated the effect of inflammation on drug transport in liver using taurocholate as a model drug. The hepatic disposition kinetics of [3H]taurocholate in perfused normal and adjuvant-treated rat livers were investigated by the multiple indicator dilution technique and data were analyzed by a previously reported hepatobiliary taurocholate transport model. Real-time RT-PCR was also performed to determine the mRNA expression of liver bile salt transporters in normal and diseased livers. The uptake and biliary excretion of taurocholate were impaired in the adjuvant-treated rats as shown by decreased influx rate constant kin (0.65 ± 0.09 vs. 2.12 ± 0.30) and elimination rate constant kbe (0.09 ± 0.02 vs. 0.17 ± 0.04) compared with control rat group, whereas the efflux rate constant kout was greatly increased (0.07 ± 0.02 vs. 0.02 ± 0.01). The changes of mRNA expression of liver bile salt transporters were found in adjuvant-treated rats. Hepatic taurocholate extraction ratio in adjuvant-treated rats (0.86 ± 0.05, n = 6) was significantly reduced compared with 0.93 ± 0.05 ( n = 6) in normal rats. Hepatic extraction was well correlated with altered hepatic ATP content ( r2 = 0.90). In conclusion, systemic inflammation greatly affects hepatic ATP content/production and associated transporter activities and causes an impairment of transporter-mediated solute trafficking and pharmacokinetics.

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