scholarly journals Confocal laser endomicroscopy for diagnosis ofHelicobacter pyloriinfection: A prospective study

2010 ◽  
Vol 25 (4) ◽  
pp. 700-705 ◽  
Author(s):  
Rui Ji ◽  
Yan-Qing Li ◽  
Xiao-meng Gu ◽  
Tao Yu ◽  
Xiu-Li Zuo ◽  
...  
Keyword(s):  
Prospective Study ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
A Prospective Study

Diagnosis of gastric intestinal metaplasia with confocal laser endomicroscopy in vivo: a prospective study

Endoscopy ◽  
2008 ◽  
Vol 40 (07) ◽  
pp. 547-553 ◽  
Author(s):  
Y.-T. Guo ◽  
Y.-Q. Li ◽  
T. Yu ◽  
T.-G. Zhang ◽  
J.-N. Zhang ◽  
...  
Keyword(s):  
Prospective Study ◽  
Intestinal Metaplasia ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Gastric Intestinal Metaplasia ◽  
A Prospective Study

Diagnostic accuracy of probe-based confocal laser endomicroscopy in detecting residual colorectal neoplasia after EMR: a prospective study

2012 ◽  
Vol 75 (3) ◽  
pp. 525-533.e1 ◽  
Author(s):  
Muhammad W. Shahid ◽  
Anna M. Buchner ◽  
Emmanuel Coron ◽  
Timothy A. Woodward ◽  
Massimo Raimondo ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Prospective Study ◽  
Colorectal Neoplasia ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
A Prospective Study

scholarly journals Probe-Based Confocal Laser Endomicroscopy for Indeterminate Biliary Strictures: Refinement of the Image Interpretation Classification

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Michel Kahaleh ◽  
Marc Giovannini ◽  
Priya Jamidar ◽  
S. Ian Gan ◽  
Paola Cesaro ◽  
...  
Keyword(s):  
Prospective Study ◽  
Interobserver Agreement ◽  
Image Interpretation ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Biliary Strictures ◽  
Inflammatory Conditions ◽  
Paris Classification ◽  
Low Sensitivity ◽  
Duct Stricture

Background. Accurate diagnosis and clinical management of indeterminate biliary strictures are often a challenge. Tissue confirmation modalities during Endoscopic Retrograde Cholangiopancreatography (ERCP) suffer from low sensitivity and poor diagnostic accuracy. Probe-based confocal laser endomicroscopy (pCLE) has been shown to be sensitive for malignant strictures characterization (98%) but lacks specificity (67%) due to inflammatory conditions inducing false positives.Methods. Six pCLE experts validated the Paris Classification, designed for diagnosing inflammatory biliary strictures, using a set of 40 pCLE sequences obtained during the prospective registry (19 inflammatory, 6 benign, and 15 malignant). The 4 criteria used included (1) multiple thin white bands, (2) dark granular pattern with scales, (3) increased space between scales, and (4) thickened reticular structures. Interobserver agreement was further calculated on a separate set of 18 pCLE sequences.Results. Overall accuracy was 82.5% (n=40retrospectively diagnosed) versus 81% (n=89prospectively collected) for the registry, resulting in a sensitivity of 81.2% (versus 98% for the prospective study) and a specificity of 83.3% (versus 67% for the prospective study). The corresponding interobserver agreement for 18 pCLE clips was fair (k=0.37).Conclusion. Specificity of pCLE using the Paris Classification for the characterization of indeterminate bile duct stricture was increased, without impacting the overall accuracy.

Assessment of Endoscopic Healing by Using Advanced Technologies Reflects Histological Healing in Ulcerative Colitis

2020 ◽  
Vol 14 (9) ◽  
pp. 1282-1289 ◽  
Author(s):  
Marietta Iacucci ◽  
Rosanna Cannatelli ◽  
Xianyong Gui ◽  
Davide Zardo ◽  
Alina Bazarova ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Roc Curves ◽  
Mucosal Healing ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
High Definition ◽  
Endoscopic Score ◽  
Virtual Chromoendoscopy ◽  
Sensitivity Specificity ◽  
A Prospective Study

Abstract Background Several studies have reported that ulcerative colitis [UC] patients with endoscopic mucosal healing may still have histological inflammation. We investigated the relationship between mucosal healing defined by modified PICaSSO [Paddington International Virtual ChromoendoScopy ScOre], Mayo Endoscopic Score [MES] and probe-based confocal laser endomicroscopy [pCLE] with histological indices in UC. Methods A prospective study enrolling 82 UC patients [male 66%] was conducted. High-definition colonoscopy was performed to evaluate the activity of the disease with MES assessed with High-Definition MES [HD-MES] and modified PICaSSO and targeted biopsies were taken; pCLE was then performed. Receiver operating characteristic [ROC] curves were plotted to determine the best thresholds for modified PICaSSO and pCLE scores that predicted histological healing according to the Robarts Histopathology Index [RHI] and ECAP ‘Extension, Chronicity, Activity, Plus’ histology score. Results A modified PICaSSO of ≤ 4 predicted histological healing at RHI ≤ 3, with sensitivity, specificity, accuracy and area under the ROC curve [AUROC] of 89.8%, 95.7%, 91.5% and 95.9% respectively. The sensitivity, specificity, accuracy and AUROC of HD-MES to predict histological healing by RHI were 81.4%, 95.7%, 85.4% and 92.1%, respectively. A pCLE ≤ 10 predicted histological healing with sensitivity of 94.9%, specificity of 91.3%, accuracy of 93.9% and AUROC of 96.5%. An ECAP of ≤ 10 was predicted by modified PICaSSO ≤ 4 with accuracy of 91.5% and AUROC of 95.9%. Conclusion Histological healing by RHI and ECAP is accurately predicted by HD-MES and modified virtual electronic chromoendoscopy PICaSSO, endoscopic score; and the use of pCLE did not improve the accuracy any further.

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