scholarly journals Impact of pretransplant antinuclear antibody and antismooth muscle antibody titers on disease recurrence and graft survival following liver transplantation in autoimmune hepatitis patients

2013 ◽  
Vol 28 (3) ◽  
pp. 537-542 ◽  
Author(s):  
Nader Dbouk ◽  
Samir Parekh
Keyword(s):  
Liver Transplantation ◽  
Autoimmune Hepatitis ◽  
Graft Survival ◽  
Antinuclear Antibody ◽  
Disease Recurrence ◽  
Antibody Titers

scholarly journals Single-Center North American Experience of Liver Transplantation in Autoimmune Hepatitis: Infrequent Indication but Good Outcomes for Patients

2020 ◽  
Author(s):  
Fernanda de Quadros Onofrio ◽  
Evon Neong ◽  
Danielle Adebayo ◽  
Dagmar Kollmann ◽  
Oyedele Adewale Adeyi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Autoimmune Hepatitis ◽  
Graft Survival ◽  
Deceased Donor ◽  
Disease Recurrence ◽  
Acute Onset ◽  
Liver Graft ◽  
Single Center ◽  
Overlap Syndromes ◽  
Patient And Graft Survival

Abstract Background and Aims A 40% risk of disease recurrence post-liver transplantation (LT) for autoimmune hepatitis (AIH) has been previously reported. Risk factors for recurrence and its impact on long-term patient outcome are poorly defined. We aimed to assess prevalence, time to disease recurrence, as well as patient and graft survival in patients with recurrent AIH (rAIH) versus those without recurrence. Methods Single-center retrospective study of adult recipients who underwent LT for AIH between January 2007 and December 2017. Patients with AIH overlap syndromes were excluded. Results A total of 1436 LTs were performed during the study period, of whom 46 (3%) for AIH. Eight patients had AIH overlap syndromes and were excluded. Patients were followed up for 4.4 ± 3.4 years and mean age at LT was 46.8 years. Average transplant MELD (Model for End-Stage Liver Disease) score was 24.9. About 21% of patients (8 of 38) were transplanted for acute onset of AIH; 66% of patients (n = 25) received a deceased donor liver graft, and 34% a living donor organ. rAIH occurred in 7.8% (n = 3/38) of recipients. Time to recurrence was 1.6, 12.2 and 60.7 months. Patient and graft survival in patients without recurrence was 88.6% and 82.8% in 5 years, whereas in those with rAIH, it was 66.7%, respectively. Conclusion Although AIH recurs post-LT, our data indicate a lower recurrence rate when compared to the literature and excellent patient and graft survival.

Long-term patient and graft survival after liver transplantation for autoimmune hepatitis

2020 ◽  
Vol 73 ◽  
pp. S21-S22
Author(s):  
Melina Heinemann ◽  
René Adam ◽  
Marina Berenguer Haym ◽  
Darius F. Mirza ◽  
Seyed Ali Malek-Hosseini ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Autoimmune Hepatitis ◽  
Graft Survival ◽  
Patient And Graft Survival

scholarly journals The impact of disease recurrence on graft survival following liver transplantation: a single centre experience

2008 ◽  
Vol 21 (5) ◽  
pp. 459-465 ◽  
Author(s):  
Ian A Rowe ◽  
Kerry Webb ◽  
Bridget K Gunson ◽  
Naimish Mehta ◽  
Sayeed Haque ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Disease Recurrence ◽  
Single Centre ◽  
Single Centre Experience ◽  
The Impact

scholarly journals O6: EARLY ANASTOMOTIC BILIARY COMPLICATIONS AFTER LIVER TRANSPLANTATION

2021 ◽  
Vol 108 (Supplement_1) ◽  
Author(s):  
SJ Tingle ◽  
ER Thompson ◽  
SS Ali ◽  
IK Ibrahim ◽  
E Irwin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Hospital Stay ◽  
Graft Survival ◽  
Cox Regression ◽  
Risk Groups ◽  
Biliary Complications ◽  
Anastomotic Strictures ◽  
Selection Of Variables ◽  
Independent Risk Factors

Abstract Introduction Biliary leaks and anastomotic strictures are common early biliary complications (EBC) following liver transplantation. However, their impact on outcomes remains controversial and poorly described. Method The NHS registry on adult liver transplantation between 2006 and 2017 was retrospectively reviewed (n=8304). Multiple imputations were performed to account for missing data. Adjusted regression models were used to assess predictors of EBC, and their impact on outcomes. 35 potential variables were included, and backwards stepwise selection enabled unbiased selection of variables for inclusion in final models. Result EBC occurred in 9.6% of patients. Adjusted cox regression revealed that EBCs have a significant and independent impact on graft survival (Leak HR=1.325; P=0.021, Stricture HR=1.514; P=0.002, Leak plus stricture HR=1.533; P=0.034) and patient survival (Leak HR=1.218; P=0.131, Stricture HR=1.578; P<0.001, Leak plus stricture HR=1.507; P=0.044). Patients with EBC had longer median hospital stay (23 versus 15 days; P<0.001) and increased chance for readmission within the first year (56% versus 32%; P<0.001). On adjusted logistic regression the following were identified as independent risk factors for development of EBC: donation following circulatory death (OR=1.280; P=0.009), accessory hepatic artery (OR=1.324; P=0.005), vascular anastomosis time in minutes (OR=1.005; P=0.032) and ethnicity ‘other’ (OR=1.838; P=0.011). Conclusion EBCs prolong hospital stay, increase readmission rates and are independent risk factors for diminished graft survival and increased mortality in liver transplantation. We have identified factors that increase the likelihood of EBC occurrence; further research into interventions to prevent EBCs in these at-risk groups is vital to improve liver transplantation outcomes. Take-home message Using a large registry database we have shown that early anastomotic biliary complications are independent risk factors for decreased graft survival and increased mortality after liver transplantation. Research into interventions to prevent biliary complications in high risk groups are essential to improve liver transplant outcomes.

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