Extracranial metastasizing solitary fibrous tumors (SFT) of meninges: Histopathological features of a case with long-term follow-up

2012 ◽  
Vol 33 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Marco Gessi ◽  
Gerrit H. Gielen ◽  
Eva-Dorette Roeder-Geyer ◽  
Clemens Sommer ◽  
Michael Vieth ◽  
...  
Keyword(s):  
Histopathological Features ◽  
Solitary Fibrous Tumors ◽  
Long Term Follow Up

scholarly journals Long-Term Outcomes of Tamoxifen Citrate Therapy and Histo- and Immunopathological Properties in Riedel Thyroiditis

2020 ◽  
pp. 1-9
Author(s):  
Asena Gökçay Canpolat ◽  
Murat Cinel ◽  
Serpil Dizbay Sak ◽  
Işılay Taşkaldıran ◽  
Hakan Korkmaz ◽  
...  
Keyword(s):  
Plasma Cells ◽  
Therapeutic Option ◽  
Treatment Options ◽  
Serum Levels ◽  
Histopathological Features ◽  
Tamoxifen Citrate ◽  
Median Period ◽  
Long Term Follow Up

<b><i>Background:</i></b> Riedel thyroiditis (RT) is a rare form of thyroiditis; thus, data about the disease course and treatment options are limited. Therefore, we aimed to assess the clinical, serological, radiological, and histopathological features, as well as short- and long-term follow-up of RT patients under glucocorticoid (GC) and tamoxifen citrate (TMX). Parameters related to IgG4-related diseases (IgG4-RD) were also investigated. <b><i>Methods:</i></b> Eight patients with RT diagnosed between 2000 and 2019 were enrolled. Data were collected in a retrospective and prospective manner. The diagnosis was confirmed with histopathological features in all patients. Results of the treatment with GCs on short- to mid-term, followed by TMX in the long term, were evaluated. <b><i>Results:</i></b> The mean age at diagnosis was 40.5 ± 6.8 years; female predominance was observed (F/M:7/1). Parameters related to IgG4-RD, like increase in IgG4 serum levels, total plasmablast counts, and IgG4+ plasmablasts, were negative in most of our patients in both active and inactive states of the disease. Likewise, an increased ratio of IgG4/IgG-positive plasma cells &#x3e;40% could only be observed in 2 cases. GCs followed by TMX were given to the patients with an over-all median follow-up time of 67 (8–216) months. All the patients considerably improved clinically and had a reduction in the size of the mass lesion on GCs, followed by TMX therapy. None of the patients had a recurrence under TMX therapy for a median period of 18.5 (7–96) months. <b><i>Conclusion:</i></b> Even though RT is suggested to be a member of IgG4-RD, serologic or histological evidence of IgG4 elevation or positivity is only useful for diagnosis and follow-up of RT. The diagnosis should be based on clinical and radiological evidence and confirmed by histopathology. GCs are effective for initial treatment, and TMX is a successful and safe therapeutic option for long-term maintenance therapy.

scholarly journals Multiple Recurrent Malignant Solitary Fibrous Tumors: Long-Term Follow-Up of 24 Years

2011 ◽  
Vol 91 (4) ◽  
pp. 1285-1288 ◽  
Author(s):  
Chang Kwon Park ◽  
Deok Heon Lee ◽  
Ji Young Park ◽  
Sun Hwa Park ◽  
Kun Young Kwon
Keyword(s):  
Solitary Fibrous Tumors ◽  
Long Term Follow Up

Clinical, virological and histopathological features: long-term follow-up in patients with chronic hepatitis C co-infected with S. mansoni

2000 ◽  
Vol 20 (4) ◽  
pp. 281-289 ◽  
Author(s):  
Sanaa Kamal ◽  
Mohamed Madwar ◽  
Leonardo Bianchi ◽  
Ahmed E. L. Tawil ◽  
Ragaa Fawzy ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Histopathological Features ◽  
Long Term Follow Up

Giant Pelvic Solitary Fibrous Tumor Obstructing Intestinal and Urinary Tract: A Case Report and Literature Review

2007 ◽  
Vol 73 (5) ◽  
pp. 478-480 ◽  
Author(s):  
Bing Yi ◽  
Chandra Bewtra ◽  
K. Yussef ◽  
Edibaldo Silva
Keyword(s):  
Solitary Fibrous Tumor ◽  
Large Bowel Obstruction ◽  
Complete Resection ◽  
Solitary Fibrous Tumors ◽  
Long Term Follow Up ◽  
High Grade Sarcoma ◽  
Fibrous Tumor ◽  
Pelvic Neoplasm

We are reporting a giant pelvic neoplasm, a rare solitary fibrous tumor that presented with a large bowel obstruction and bilateral ureteral obstruction because of its size and location. Preoperative diagnosis required complex pathological studies to exclude a high-grade sarcoma suspected clinically. Complete resection was required for resolution of obstructive symptoms. Prognosis for solitary fibrous tumors is usually good after complete resection. Recurrence and metastasis may be related to rare aggressive histological features, including nuclear atypia, hypercellularity, greater than four mitoses/10 high power fields, and necrosis. Because histology is not always a reliable predictor of prognosis, careful long-term follow-up is necessary for this tumor. Solitary fibrous tumors (SFTs) are rare spindle cell neoplasms most likely arising from mesenchymal cells. SFTs were originally described in the pleura, the most common site for this tumor; however, extrathoracic SFTs are seemingly diagnosed with increased frequency. We report a case of a giant pelvic SFT that required complicated clinical management.

Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

2019 ◽  
Vol 42 ◽  
Author(s):  
John P. A. Ioannidis
Keyword(s):  
Mental Health ◽  
Mental Disease ◽  
Brain Disorders ◽  
Social Stressors ◽  
Labor Education ◽  
Mental Diseases ◽  
Long Term Follow Up ◽  
Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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