Long-Term Follow-Up and Clinico-Histopathological Features of Simpson Grade 1 Surgical Resection of Large Olfactory Groove Meningioma

Introduction. The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn’s disease, where there is no absolute indication of surgery. Methods. Observational study involving patients with isolated ileocecal Crohn’s disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit. Statistical analysis was done using Analysis of Variance (ANOVA) to compare the different figures. Results. There was a statistically significant increase in the hemoglobin levels between preoperative, postoperative, and long-term follow-up and a significant decrease in leukocyte count between the pre- and postoperative values (F=19.8, p<0.001 and F=8.9, p=0.002, resp.). Similarly, the ESR and CRP values were decreased significantly at long-term follow-up (F=8.5, p=0.019 and F=8.3, p=0.013, resp.). Conclusion. Early surgical resection in isolated ileocaecal Crohn’s disease achieved significant biochemical improvements. These successful results in this small number of patients indicate that early surgical intervention may provide better outcomes. These initial results encourage larger and comparative studies of long-term results versus long-term use of biological agents.

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Salvage Surgical Resection After Linac-based Stereotactic Radiosurgery and Radiotherapy for Newly Diagnosed Brain Metastasis

10.21203/rs.3.rs-272644/v1 ◽

2021 ◽

Author(s):

Ryosuke Matsuda ◽

Takayuki Morimoto ◽

Tetsuro Tamamoto ◽

Nobuyoshi Inooka ◽

Tomoko Ochi ◽

...

Keyword(s):

Brain Metastasis ◽

Survival Time ◽

Stereotactic Radiosurgery ◽

Surgical Resection ◽

Cyst Formation ◽

Histopathological Diagnosis ◽

Newly Diagnosed ◽

Long Term Follow Up

Abstract Purpose: This study aimed to assess the clinical outcomes of salvage surgical resection (SSR) after stereotactic radiosurgery and fractionated stereotactic radiotherapy (SRS/fSRT) for brain metastasis.Methods: Between November 2009 and December 2018, we treated 427 consecutive patients with 919 lesions with SRS/fSRT for newly diagnosed brain metastasis at our hospital. During the follow-up period, we treated 19 consecutive patients who underwent 21 SSRs for recurrence, radiation necrosis (RN), and cyst formation after SRS/fSRT for newly diagnosed brain metastasis. Two patients underwent multiple surgical resections. Brain metastasis originated from the lung (n=15, 78.9%), breast (n=3, 15.7%), and colon (n=1, 5.2%). Results: The median time from initial SRS/fSRT to SSR was 14 months (range: 2–96 months). The median follow-up after SSR was 15 months (range: 2–76 months). The range of tumor volume at initial SRS/SRT was 0.121–21.459 cm3 (median: 2.188 cm3). Histopathological diagnosis after SSR was recurrence, RN and cyst formation in 13 and 6 cases, respectively. The median survival time from SSR and from initial SRS/SRT was 17 months and 74 months, respectively. The cases with recurrence had a significantly shorter survival time than those without recurrence (p=0.0453).Conclusion: The patients treated with SRS/fSRT for brain metastasis need long-term follow-up. SSR is a safe and effective treatment for the recurrence, RN, and cyst formation after SRS/fSRT for brain metastasis.

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Extracranial metastasizing solitary fibrous tumors (SFT) of meninges: Histopathological features of a case with long-term follow-up

Neuropathology ◽

10.1111/j.1440-1789.2012.01319.x ◽

2012 ◽

Vol 33 (1) ◽

pp. 68-74 ◽

Cited By ~ 4

Author(s):

Marco Gessi ◽

Gerrit H. Gielen ◽

Eva-Dorette Roeder-Geyer ◽

Clemens Sommer ◽

Michael Vieth ◽

...

Keyword(s):

Histopathological Features ◽

Solitary Fibrous Tumors ◽

Long Term Follow Up

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Long-term follow-up of conjunctival melanoma treated with topical interferon alpha-2b eye drops as adjunctive therapy following surgical resection

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-017-3754-2 ◽

2017 ◽

Vol 255 (11) ◽

pp. 2271-2276 ◽

Cited By ~ 12

Author(s):

Iku Kikuchi ◽

Satoru Kase ◽

Kan Ishijima ◽

Susumu Ishida

Keyword(s):

Surgical Resection ◽

Interferon Alpha ◽

Adjunctive Therapy ◽

Eye Drops ◽

Conjunctival Melanoma ◽

Interferon Alpha 2B ◽

Long Term Follow Up

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Long-Term Outcomes of Tamoxifen Citrate Therapy and Histo- and Immunopathological Properties in Riedel Thyroiditis

European Thyroid Journal ◽

10.1159/000512017 ◽

2020 ◽

pp. 1-9

Author(s):

Asena Gökçay Canpolat ◽

Murat Cinel ◽

Serpil Dizbay Sak ◽

Işılay Taşkaldıran ◽

Hakan Korkmaz ◽

...

Keyword(s):

Plasma Cells ◽

Therapeutic Option ◽

Treatment Options ◽

Serum Levels ◽

Histopathological Features ◽

Tamoxifen Citrate ◽

Median Period ◽

Long Term Follow Up

Background: Riedel thyroiditis (RT) is a rare form of thyroiditis; thus, data about the disease course and treatment options are limited. Therefore, we aimed to assess the clinical, serological, radiological, and histopathological features, as well as short- and long-term follow-up of RT patients under glucocorticoid (GC) and tamoxifen citrate (TMX). Parameters related to IgG4-related diseases (IgG4-RD) were also investigated. Methods: Eight patients with RT diagnosed between 2000 and 2019 were enrolled. Data were collected in a retrospective and prospective manner. The diagnosis was confirmed with histopathological features in all patients. Results of the treatment with GCs on short- to mid-term, followed by TMX in the long term, were evaluated. Results: The mean age at diagnosis was 40.5 ± 6.8 years; female predominance was observed (F/M:7/1). Parameters related to IgG4-RD, like increase in IgG4 serum levels, total plasmablast counts, and IgG4+ plasmablasts, were negative in most of our patients in both active and inactive states of the disease. Likewise, an increased ratio of IgG4/IgG-positive plasma cells >40% could only be observed in 2 cases. GCs followed by TMX were given to the patients with an over-all median follow-up time of 67 (8–216) months. All the patients considerably improved clinically and had a reduction in the size of the mass lesion on GCs, followed by TMX therapy. None of the patients had a recurrence under TMX therapy for a median period of 18.5 (7–96) months. Conclusion: Even though RT is suggested to be a member of IgG4-RD, serologic or histological evidence of IgG4 elevation or positivity is only useful for diagnosis and follow-up of RT. The diagnosis should be based on clinical and radiological evidence and confirmed by histopathology. GCs are effective for initial treatment, and TMX is a successful and safe therapeutic option for long-term maintenance therapy.

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Long-term follow-up of surgical resection of microcystic meningiomas

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2014.12.004 ◽

2015 ◽

Vol 22 (4) ◽

pp. 713-717 ◽

Cited By ~ 5

Author(s):

M. Yashar S. Kalani ◽

Claudio Cavallo ◽

Stephen W. Coons ◽

Salvatore C. Lettieri ◽

Peter Nakaji ◽

...

Keyword(s):

Surgical Resection ◽

Long Term Follow Up

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Long survival and recurrence of thymic carcinoma 10 years after resection

Asian Cardiovascular and Thoracic Annals ◽

10.1177/0218492319848958 ◽

2019 ◽

Vol 27 (5) ◽

pp. 407-409 ◽

Cited By ~ 1

Author(s):

Hiroshi Yabuki ◽

Muneo Minowa

Keyword(s):

Cell Carcinoma ◽

Surgical Resection ◽

Mediastinal Tumor ◽

Thymic Carcinoma ◽

Rapid Progression ◽

Rare Type ◽

Long Term Follow Up ◽

Thymic Carcinomas

Thymic carcinomas are a rare type of malignant mediastinal tumor. Thymic carcinomas have a rapid progression, and recurrence and metastasis usually occur in the early phase after surgical resection. To the best of our knowledge, recurrence more than 10 years after surgical resection has been reported in only one case of neuroendocrine cell carcinoma. We report a case of resected thymic squamous cell carcinoma recurring after 10 years, which indicates that thymic carcinomas require long-term follow-up after surgical resection.

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