Folic acid 5 or 15 mg/d similarly reduces plasma homocysteine in patients with moderate-advanced chronic renal failure

Nephrology ◽  
2006 ◽  
Vol 11 (2) ◽  
pp. 137-141 ◽  
Author(s):  
AMELIA R BERNASCONI ◽  
ANDRES LISTE ◽  
NOEMI DEL PINO ◽  
GUILLERMO J ROSA DIEZ ◽  
RICARDO M HEGUILEN
2003 ◽  
Vol 73 (3) ◽  
pp. 215-220 ◽  
Author(s):  
de Gómez Dumm ◽  
Giammona ◽  
Touceda

Dyslipidemia and increases in plasma homocysteine usually occur at end-stage renal disease; both are recognized as risk factors for atherosclerosis. Folate administration reduces homocysteine concentration. In this study we determined the effect of a high dose of folic acid (40 mg intravenous injection three times a week) on plasma and red blood cell lipid profiles in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (baseline) and after 21, 42, and 64 days of treatment. Folic acid supplementation decreased plasma homocysteine. Plasma triglyceride levels decreased whereas polyunsaturated fatty acid values increased after 21 days; then they returned to baseline levels at the end of treatment. Total cholesterol and low-density lipoprotein (LDL) cholesterol were higher than those of the baseline during all the study, whereas high-density lipoprotein (HDL) cholesterol was reduced. In erythrocyte membranes, folic acid therapy enhanced cholesterol/phospholipid ratios and the fluorescence anisotropy of diphenyl-hexatriene. We conclude that large doses of folic acid produce a favorable effect, reducing plasma homocysteine levels and protecting patients from atherosclerosis. However, as this therapy induces significant alterations in both plasma and erythrocyte membrane lipid profiles, plasma lipid values should be controlled throughout the treatment of patients with renal failure.


2002 ◽  
Vol 17 (7) ◽  
pp. 511-514 ◽  
Author(s):  
Hee Kang ◽  
Byong Lee ◽  
Hyewon Hahn ◽  
Jun Lee ◽  
Il Ha ◽  
...  

Chronic Renal Failure (CRF) is a disease caused due to kidney damage or deterioration glomerulus filtrate rate (GFR/GFR/Glomerular Filtration Rate) <60 ml/min /1.73 m2 for ≥ 3 months. One of the complications that often appears in CRF is anemia or decrease of hemoglobin level in the blood that is related to the relationship intake of nutrients (protein, vitamin C, folic acid and iron). The purpose of this study was to determine the relationship Intake of nutrients (protein, vitamin C, folic acid and iron) on Hb levels of chronic renal failure patients undergoing hemodialysis in RSI Siti Khadijah Palembang. This type of research is an observational analytic with a cross-sectional study design. Population in this study were all outpatients with chronic renal failure undergoing hemodialysis in RSI Siti Khadijah Palembang with total research subjects were 50 subjects, taken using purposive sampling and analyzed using chi-square test. The result showed that there are 52% of patients with chronic renal failure are male more than female. The aged 50-64 years old is 44% and 30-49 years old are 32%. The percentage of outpatients who had an adequate intake of protein, vitamin C, folic acid and iron were 28%, 10%, 0%, and 18% respectively, meanwhile, most of the patients had low hemoglobin levels which were 94%. There was not a significant association between intake of nutrients (protein, vitamin C, folic acid and iron) on Hb levels of chronic renal failure patients undergoing hemodialysis in RSI Siti Khadijah Palembang. Based on these results, should be noted again nutrient intake (protein, vitamin C, folic acid and iron) outpatient before and after undergoing hemodialysis to support the optimal outcome of hemodialysis therapy.


2004 ◽  
Vol 37 (11) ◽  
pp. 974-976 ◽  
Author(s):  
Sandy Slow ◽  
David O. McGregor ◽  
Michael Lever ◽  
Martin B. Lee ◽  
Peter M. George ◽  
...  

Circulation ◽  
2000 ◽  
Vol 102 (8) ◽  
pp. 871-875 ◽  
Author(s):  
J. Thambyrajah ◽  
M. J. Landray ◽  
F. J. McGlynn ◽  
H. J. Jones ◽  
D. C. Wheeler ◽  
...  

2003 ◽  
Vol 12 (2) ◽  
pp. A44-A45
Author(s):  
Sophia Zoungas ◽  
Barry P. McGrath ◽  
Sonya Ristevski ◽  
Pauline Branley ◽  
James D. Cameron ◽  
...  

2001 ◽  
Vol 16 (10) ◽  
pp. 805-811 ◽  
Author(s):  
A. Merouani ◽  
Marie Lambert ◽  
Edgar E. Delvin ◽  
Jacques Genest Jr. ◽  
Pierre Robitaille ◽  
...  

Circulation ◽  
2002 ◽  
Vol 105 (15) ◽  
pp. 1810-1815 ◽  
Author(s):  
K. Bennett-Richards ◽  
M. Kattenhorn ◽  
A. Donald ◽  
G. Oakley ◽  
Z. Varghese ◽  
...  

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