Detection of specific genetic abnormalities by fluorescence in situ hybridization in soft tissue tumors

2011 ◽  
Vol 62 (1) ◽  
pp. 16-27 ◽  
Author(s):  
Yasuhiro Miura ◽  
Yoshiko Keira ◽  
Jiro Ogino ◽  
Katsuya Nakanishi ◽  
Hiroko Noguchi ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Fluorescence In Situ Hybridization ◽  
Soft Tissue Tumors ◽  
Genetic Abnormalities

Detection of VHL deletion by fluorescence in situ hybridization in extraneuraxial hemangioblastoma of soft tissue

2020 ◽  
Vol 70 (7) ◽  
pp. 473-475
Author(s):  
Keiko Segawa ◽  
Shintaro Sugita ◽  
Tomoyuki Aoyama ◽  
Seiichi Minami ◽  
Kazuo Nagashima ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Fluorescence In Situ Hybridization

Detection of Bacteria by Fluorescence in Situ Hybridization in Culture-Negative Soft Tissue Filler Lesions

2009 ◽  
Vol 35 ◽  
pp. 1620-1624 ◽  
Author(s):  
THOMAS BJARNSHOLT ◽  
TIM TOLKER-NIELSEN ◽  
MICHAEL GIVSKOV ◽  
MARTIN JANSSEN ◽  
LISE HANNE CHRISTENSEN
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Fluorescence In Situ Hybridization ◽  
Soft Tissue Filler ◽  
Culture Negative

Update on Fluorescence In Situ Hybridization in Melanoma: State of the Art

2011 ◽  
Vol 135 (7) ◽  
pp. 830-837 ◽  
Author(s):  
Pedram Gerami ◽  
Artur Zembowicz
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Personal Experience ◽  
State Of The Art ◽  
Review Of The Literature ◽  
Multicolor Fish ◽  
Melanocytic Lesions ◽  
Genetic Abnormalities

Abstract Context.—Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4-probe multicolor FISH probe panel targeting chromosomes 6 and 11. Validation studies showed promising sensitivity and specificity for distinguishing benign nevi and malignant melanoma by FISH. Recent studies show that a melanoma FISH assay has great potential for becoming an important diagnostic adjunct in classification of melanocytic lesions and in diagnosis of melanoma. Objective.—To present a comprehensive review of the science and practical aspects of FISH in melanoma for pathologists considering the use of melanoma FISH in their practice. Data Sources.—Review of the literature and personal experience of the authors. Conclusions.—Judicious use of a 4-probe multicolor melanoma FISH procedure can enhance accuracy for diagnosis of melanoma and improve classification of melanocytic proliferations.

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