Congenital brain tumor: Fetal case of congenital germ cell intracranial tumor

✓ On November 25, 1884, Mr. Rickman J. Godlee performed the first recognized resection of a primary brain tumor. This operation was carried out at the suggestion of Dr. A. Hughes Bennett, a neurologist at The Hospital for Epilepsy and Paralysis, Regents Park, London, England. Other operations for intracranial tumor had been performed but were for extracerebral meningeal or osseous tumors. The “first” operation for a primary cerebral tumor by Godlee was meticulously described and well documented in the medical and popular press of the day and stimulated both professional and lay discussions of the topic that directly and indirectly led to further surgery on the cerebrum itself and the advent of modern neurosurgery. The original patient of Mr. Godlee died on the 28th postoperative day of apparent meningitis and secondary complications, but postmortem examination revealed no remnant of the excised glioma.

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Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy

Journal of Neurosurgery ◽

10.3171/jns.1993.79.4.0577 ◽

1993 ◽

Vol 79 (4) ◽

pp. 577-583 ◽

Cited By ~ 5

Author(s):

Bruce F. Kimler ◽

Changnian Liu ◽

Richard G. Evans ◽

Robert A. Morantz

Keyword(s):

Radiation Therapy ◽

Brain Tumor ◽

Rat Brain ◽

Tumor Model ◽

Intracranial Tumor ◽

Normal Brain ◽

Animal Survival ◽

Significant Difference ◽

Rat Brain Tumor ◽

Brain Tumor Model

✓ The authors attempted to confirm published reports that pentobarbital protects against radiation-induced damage to normal rat brain, as well as enhances radiotherapeutic efficacy in a rat brain tumor model. They evaluated animal survival in 9L gliosarcoma-burdened rats that received whole-brain radiation therapy (16, 24, 32, or 40 Gy) while under intraperitoneal pentobarbital (60 mg/kg) or intramuscular ketamine (60 mg/kg) sedation. The animals were examined at autopsy to attribute death to either intracranial tumor growth or normal brain toxicity in the absence of discernible tumor. There was no difference between the two anesthesia groups regarding the survival of unirradiated animals. Radiation therapy produced a significant dose-dependent prolongation in animal survival, which was limited by the development of normal tissue toxicity at the higher doses. When compared to ketamine anesthesia, pentobarbital anesthesia appeared to offer some protection (not statistically significant) against early (but not late) toxicity at selected radiation doses. A reduction in the number of deaths from tissue toxicity suggested an increased antitumor effect, but again this was not statistically significant. Only in one case was there even a marginal significant difference (p = 0.045) between overall therapeutic efficacy in rats sedated with pentobarbital versus ketamine. While there may be a radioprotective effect of pentobarbital in rat brains without intracranial tumor, there is no conclusive evidence for either radioprotection or significant improvement of radiotherapeutic efficacy in this 9L rat brain tumor model.

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Time course analysis and modulating effects of established brain tumor on active-specific immunotherapy

Neurosurgical FOCUS ◽

10.3171/foc.2000.9.6.4 ◽

2000 ◽

Vol 9 (6) ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Yang Liu ◽

Ka-Yun Ng ◽

Kevin O. Lillehei

Keyword(s):

Brain Tumor ◽

Tumor Cell ◽

Time Course ◽

Cell Function ◽

Tumor Vaccine ◽

Tumor Regression ◽

Preventive Therapy ◽

Time Of Day ◽

Intracranial Tumor ◽

Spleen Cells

Object There have been numerous attempts to establish an effective immunotherapy for the treatment of brain tumors. To date, reliable methods to manipulate the immune system for promoting brain tumor regression have been disappointing. Generation of active immune responses in most of these studies was only possible in the absence of viable tumor cells, suggesting that immunotherapy can only be used as preventive therapy. In few studies the investigators have demonstrated success in using immunotherapy to treat a preestablished intracranial tumor. Using the 9L intracranial glioma model, the authors sought to delineate the underlying mechanisms for these observations. Methods In animals vaccinated with irradiated 9L glioma cells and interferon-gamma 14 and 7 days prior to intracranial tumor cell challenge, a significant increase in survival was shown. In contrast, vaccinations applied 3 days prior to, at the time of (Day 0) or 7 days after intracranial tumor cell challenge failed to influence survival. Histological examination of brain tissue specimens obtained in animals vaccinated before or after tumor cell challenge showed no difference in the degree of peritumoral mononuclear cell infiltration. When activated spleen cells obtained obtained from these animals were assayed for cytotoxicity and proliferative capacity, only those spleen cells derived from animals vaccinated prior to intracranial tumor cell challenge showed enhanced activity. Conclusions These data support the presence of a strong modulatory effect of tumor on local and systemic antitu-moral immune response. This immunosuppression appears to be secondary to a direct effect on T-cell function. Reversal of this immunosuppression may be a useful adjunct to tumor vaccine therapy.

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Three-dimensional magnetic resonance reconstruction images before and after surgical therapy of spontaneous canine brain tumors

Ciência Rural ◽

10.1590/s0103-84782007000400044 ◽

2007 ◽

Vol 37 (4) ◽

pp. 1174-1177

Author(s):

Julio Carlos Canola ◽

Fabrício Singaretti de Oliveira

Keyword(s):

Brain Tumor ◽

Magnetic Resonance ◽

Surgical Planning ◽

Tumor Volume ◽

Three Dimensional ◽

Treatment Monitoring ◽

Magnetic Resonance Images ◽

Intracranial Tumor ◽

Anatomical Structures ◽

Before And After

Specific software was used for reconstruction of spontaneous intracranial tumor volume from magnetic resonance images (MRI) in three dogs. Histopathologically confirmed meningioma, cystic meningioma, and choroid plexus tumors were evaluated before and after surgery. The software allowed the whole-volume segmentation of the skin, brain, tumor, edema, and cyst. Manipulation of the three-dimensional images (3D) allowed visualization of all anatomical structures, aided clinical understanding, surgical planning, and treatment monitoring.

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Intracranial Adenocystic Carcinoma Presenting as a Primary Brain Tumor

Neurosurgery ◽

10.1227/00006123-198303000-00021 ◽

1983 ◽

Vol 12 (3) ◽

pp. 348-352 ◽

Cited By ~ 12

Author(s):

Joseph M. Piepmeier ◽

Chat Virapongse ◽

Leon E. Kier ◽

Jung Kim ◽

Alvin Greenberg

Keyword(s):

Brain Tumor ◽

Trigeminal Nerve ◽

Primary Brain Tumor ◽

Intracranial Tumor ◽

Primary Intracranial Tumor ◽

Work Up

Abstract We present a case of an intracranial adenocystic carcinoma that clinically and radiographically mimicked a primary intracranial tumor. The radiological work-up of this tumor is presented in detail. We suggest that perineural intracranial invasion by the tumor along the trigeminal nerve resulted in its presentation as a primary intracranial tumor.

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