Activity-dependent Regulation of N-Methyl-d-aspartate Receptor Subunit Expression in Rat Cerebellar Granule Cells

1994 ◽  
Vol 6 (12) ◽  
pp. 1792-1800 ◽  
Author(s):  
Etienne Audinat ◽  
Bertrand Lambolez ◽  
Jean Rossier ◽  
Francis Crépel
Keyword(s):  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Receptor Subunit ◽  
Cerebellar Granule ◽  
Aspartate Receptor ◽  
Subunit Expression ◽  
Activity Dependent

scholarly journals The Expression of the PDZ Protein MALS-1/Velis Is Regulated by Calcium and Calcineurin in Cerebellar Granule Cells

2002 ◽  
Vol 277 (51) ◽  
pp. 49585-49590 ◽  
Author(s):  
Bastiano Sanna ◽  
Dana Kramer ◽  
Armando A. Genazzani
Keyword(s):  
Gene Expression ◽  
Neuronal Development ◽  
Granule Cells ◽  
De Novo ◽  
Cerebellar Granule Cells ◽  
Transcriptional Level ◽  
Synaptic Density ◽  
Cerebellar Granule ◽  
Activity Dependent ◽  
Post Synaptic Density

Activity-dependent gene expression is thought to be important in shaping neuronal development and in modifying the protein content of neurons. Ca2+entry into neurons appears to be one of the key effectors of activity-dependent gene expression. Among the possible downstream targets of calcium, the protein phosphatase calcineurin represents a prime candidate. We hereby report that in cultured cerebellar granule cells the activation of the Ca2+/calcineurin pathway via either voltage- or ligand- operated Ca2+channels regulates MALS-1 and MALS-2 expression at the transcriptional level. These proteins are integral parts of the post-synaptic density and are also involved in receptor trafficking. MALS regulation is not at the level of mRNA stability and does not requirede novoprotein synthesis, thereby suggesting a direct pathway. These data suggest that Ca2+entry by means of calcineurin is capable of controlling the structure of the post-synaptic density by controlling the expression of key components at the transcriptional level.

scholarly journals NMDA induces post-transcriptional regulation of α2-guanylyl-cyclase-subunit expression in cerebellar granule cells

2006 ◽  
Vol 119 (8) ◽  
pp. 1622-1631 ◽  
Author(s):  
Sandra Jurado ◽  
Fernando Rodríguez-Pascual ◽  
José Sánchez-Prieto ◽  
Francisco M. Reimunde ◽  
Santiago Lamas ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Guanylyl Cyclase ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cerebellar Granule ◽  
Subunit Expression ◽  
Post Transcriptional Regulation
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