Fresh gas flow changes during controlled mechanical ventilation with the circle breathing system have significantly greater effects on the ventilatory parameters of toddlers compared with children

1992 ◽  
Vol 2 (3) ◽  
pp. 211-215 ◽  
Author(s):  
R. MOYNIHAN ◽  
C J. COTÉ
2017 ◽  
Vol 86 (5-6) ◽  
Author(s):  
Miljenko Križmarić

Tis article addresses the different functions of anesthesia reservoir bag in a breathing system. A main purpose of the contribution was to explain complex interaction between the reservoir bag and fresh gas flow during mechanical ventilation. The anesthesia reservoir bag is a collapsible gas container which is an essential component of most breathing systems. The anesthesia reservoir bag permits manual ventilation and acts as a visual or tactile indicator of spontaneous ventilation. The bag was excluded from traditional breathing system when the ventilator was in use. Discrepancies between the set and actual tidal volume can occur. However, on some anesthesia workstation systems, such as the Dräger Primus, the reservoir bag is an integral part of the breathing system during mechanical ventilation, where it serves as a reservoir for oxygen and anaesthetic gases. In mechanically ventilated patients, gases enter the bag from the fresh gas flow during inspiration, when the decoupling valve closes. The safe administration of general anesthesia requires understanding of the technological advances in highly sophisticated anesthetic equipment.


Anaesthesia ◽  
2008 ◽  
Vol 63 (8) ◽  
pp. 833-836 ◽  
Author(s):  
E. C. Russell ◽  
I. Wrench ◽  
M. Feast ◽  
F. Mohammed

Author(s):  
Martin Bellgardt ◽  
Dominik Drees ◽  
Vladimir Vinnikov ◽  
Adrian I. Georgevici ◽  
Livia Procopiuc ◽  
...  

AbstractTo identify the better volatile anaesthetic delivery system in an intensive care setting, we compared the circle breathing system and two models of reflection systems (AnaConDa™ with a dead space of 100 ml (ACD-100) or 50 ml (ACD-50)). These systems were analysed for the parameters like wash-in, consumption, and wash-out of isoflurane and sevoflurane utilising a test lung model. The test lung was connected to a respirator (circle breathing system: Aisys CS™; ACD-100/50: Puriton Bennett 840). Set parameters were volume-controlled mode, tidal volume-500 ml, respiratory rate-10/min, inspiration time-2 sec, PEEP-5 mbar, and oxygen-21%. Wash-in, consumption, and wash-out were investigated at fresh gas flows of 0.5, 1.0, 2.5, and 5.0 l/min. Anaesthetic target concentrations were 0.5, 1.0, 1.5, 2.0, and 2.5%.  Wash-in was slower in ACD-100/-50 compared to the circle breathing system, except for fresh gas flows of 0.5 and 1.0 l/min. The consumption of isoflurane and sevoflurane in ACD-100 and ACD-50 corresponded to the fresh gas flow of 0.5-1.0 l/min in the circle breathing system. Consumption with ACD-50 was higher in comparison to ACD-100, especially at gas concentrations > 1.5%. Wash-out was quicker in ACD-100/-50 than in the circle breathing system at a fresh gas flow of 0.5 l/min, however, it was longer at all the other flow rates. Wash-out was comparable in ACD-100 and ACD-50. Wash-in and wash-out were generally quicker with the circle breathing system than in ACD-100/-50. However, consumption at 0.5 minimum alveolar concentration was comparable at flows of 0.5 and 1.0 l/min.


BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ruining Liu ◽  
Gang Li ◽  
Haoli Ma ◽  
Xianlong Zhou ◽  
Pengcheng Wang ◽  
...  

Abstract Background Ventilator-induced diaphragmatic dysfunction (VIDD) is associated with weaning difficulties, intensive care unit hospitalization (ICU), infant mortality, and poor long-term clinical outcomes. The expression patterns of long noncoding RNAs (lncRNAs) and mRNAs in the diaphragm in a rat controlled mechanical ventilation (CMV) model, however, remain to be investigated. Results The diaphragms of five male Wistar rats in a CMV group and five control Wistar rats were used to explore lncRNA and mRNA expression profiles by RNA-sequencing (RNA-seq). Muscle force measurements and immunofluorescence (IF) staining were used to verify the successful establishment of the CMV model. A total of 906 differentially expressed (DE) lncRNAs and 2,139 DE mRNAs were found in the CMV group. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to determine the biological functions or pathways of these DE mRNAs. Our results revealed that these DE mRNAs were related mainly related to complement and coagulation cascades, the PPAR signaling pathway, cholesterol metabolism, cytokine-cytokine receptor interaction, and the AMPK signaling pathway. Some DE lncRNAs and DE mRNAs determined by RNA-seq were validated by quantitative real-time polymerase chain reaction (qRT-PCR), which exhibited trends similar to those observed by RNA-sEq. Co-expression network analysis indicated that three selected muscle atrophy-related mRNAs (Myog, Trim63, and Fbxo32) were coexpressed with relatively newly discovered DE lncRNAs. Conclusions This study provides a novel perspective on the molecular mechanism of DE lncRNAs and mRNAs in a CMV model, and indicates that the inflammatory signaling pathway and lipid metabolism may play important roles in the pathophysiological mechanism and progression of VIDD.


2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Marc Bodenstein ◽  
Stefan Boehme ◽  
Stephan Bierschock ◽  
Andreas Vogt ◽  
Matthias David ◽  
...  

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