Comparison of effects of combined ACE inhibitor and low-dose thiazide diuretic with ACE inhibitor alone on insulin action in patients with hypertension and Type 2 diabetes: a double-blind crossover study

2008 ◽  
Vol 25 (5) ◽  
pp. 631-634 ◽  
Author(s):  
D. M. McLaughlin ◽  
A. B. Atkinson ◽  
C. N. Ennis ◽  
J. Browne ◽  
S. J. Hunter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Crossover Study ◽  
Insulin Action ◽  
Thiazide Diuretic ◽  
Low Dose ◽  
Ace Inhibitor ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

scholarly journals Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics—A Randomized, Placebo-Controlled, Double-Blind Crossover Study

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 417 ◽  
Author(s):  
Janina Rynarzewski ◽  
Lisa Dicks ◽  
Benno Zimmermann ◽  
Birgit Stoffel-Wagner ◽  
Norbert Ludwig ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Crossover Study ◽  
Density Lipoprotein ◽  
Postprandial Glucose ◽  
Double Blind ◽  
Cocoa Powder ◽  
Glucose And Lipid Metabolism ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Randomized controlled trials indicate that flavanol-rich cocoa intake may improve postprandial glucose and lipid metabolism in patients with type 2 diabetes (T2D), based on studies with meals that impose a strong metabolic load. Hence, the aim of the present study was to investigate whether flavanol-rich cocoa powder ingested as part of a diabetic-suitable meal may beneficially affect glucose, lipid metabolism, and blood pressure (BP) in patients with T2D. Twelve adults with T2D, overweight/obesity, and hypertension ingested capsules with 2.5 g of flavanol-rich cocoa or microcrystalline cellulose with a diabetic-suitable breakfast in a randomized, placebo-controlled, double-blind crossover study. BP was measured and blood samples were taken before, 2 and 4 h after breakfast and capsule intake. Cocoa treatment did not affect glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, and BP. For glucose, insulin and HOMA-IR, only effects by time were observed after both treatments. Thus, 2.5 g of flavanol-rich cocoa powder ingested as part of a diabetic-suitable meal does not seem to affect postprandial glucose and lipid metabolism and BP in stably-treated diabetics. Nevertheless, future studies with close-meshed investigations are desirable, providing realistic amounts of cocoa together with realistic meals rich in carbohydrates to subjects with T2D or metabolic syndrome, which do not afford pharmacological treatment.

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

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