The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris

2011 ◽  
Vol 27 (3) ◽  
pp. 387-390 ◽  
Author(s):  
H. Mortazavi ◽  
F. Babaeijandaghi ◽  
M. Akbarzadeh ◽  
N. Rezaei ◽  
A.A. Amirzargar ◽  
...  
Keyword(s):  
Systemic Therapy ◽  
Pemphigus Vulgaris ◽  
Serum Levels

scholarly journals Serum Levels of Autoantibodies to Desmoglein 3 in Patients with Therapy-resistant Pemphigus Vulgaris Successfully Treated with Adjuvant Intravenous Immunoglobulins

2003 ◽  
Vol 84 (1) ◽  
pp. 48-52
Author(s):  
Detlef Zillikens ◽  
Susanne Herzog ◽  
Enno Schmidt ◽  
Matthias Goebeler ◽  
Bröcker Eva-B.
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Intravenous Immunoglobulins ◽  
Desmoglein 3

scholarly journals Clinical and Therapeutic Trial for the Efficacy of Narrow Band - UVB Phototherapy versus Systemic Therapy in Moderate and Severe Atopic Dermatitis of the Adult

2018 ◽  
Vol 64 (1) ◽  
pp. 17-21
Author(s):  
Gyula Laszlo Fekete ◽  
László Fekete
Keyword(s):  
Atopic Dermatitis ◽  
Side Effects ◽  
Systemic Therapy ◽  
Systemic Corticosteroid ◽  
Corticosteroid Treatment ◽  
Serum Levels ◽  
Severe Atopic Dermatitis ◽  
Therapeutic Trial ◽  
Group I ◽  
Uvb Phototherapy

AbstractObjectives: The aim of this clinical and therapy study was to evaluate the efficacy of NB-UVB phototherapy versus systemic therapy in moderate-to-severe atopic dermatitis of the adult.Material and methods: The subjects of the study were divided into two groups of 25 adult patients with moderate and severe atopic dermatitis according to the inclusion criteria. The first group of 25 patients were treated with systemic corticosteroids while the second group of 25 patients were treated with NB-UVB phototherapy. At the end of the study, after all the data were centralized, we performed a statistical analysis of the results, comparing the two groups as well as the efficacy of the different therapies.Results: In group I the clinical efficacy of the systemic corticosteroid treatment was achieved, on average, at 4 weeks in patients with moderate atopic dermatitis and at 6 weeks in patients with severe atopic dermatitis. In group II the clinical effecacy of NB-UVB phototherapy was achieved, on average, at 6 weeks for patients with moderate atopic dermatitis and at 8 weeks for those with the severe form. In both groups, the total IgE serum levels were elevated at the beginning, and they became normal throughout the clinical improvement. Remarkable therapy-related side effects were found in the first study group.Conclusion: We conclude that NB-UVB phototherapy had similar efficacy in treating moderate-to-severe atopic dermatitis with minimal side effects compared to systemic corticosteroid therapy.

Serum levels of soluble PD1 in pemphigus vulgaris: A useful marker for disease severity

2020 ◽  
Author(s):  
Ola Abu Zeid ◽  
Laila Rashed ◽  
Shimaa Khalifa ◽  
Marwah Adly Saleh ◽  
Nanis Ragab
Keyword(s):  
Disease Severity ◽  
Pemphigus Vulgaris ◽  
Serum Levels

Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris

2006 ◽  
Vol 155 (2) ◽  
pp. 330-336 ◽  
Author(s):  
N. Asashima ◽  
M. Fujimoto ◽  
R. Watanabe ◽  
H. Nakashima ◽  
N. Yazawa ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Pemphigus Vulgaris ◽  
Serum Levels

scholarly journals Correlation between IL-36α and IL-17 and Activity of the Disease in Selected Autoimmune Blistering Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Agnieszka Żebrowska ◽  
Anna Woźniacka ◽  
Katarzyna Juczyńska ◽  
Kamila Ociepa ◽  
Elżbieta Waszczykowska ◽  
...  
Keyword(s):  
Dermatitis Herpetiformis ◽  
Tissue Injury ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Control Group ◽  
Specific Antibodies ◽  
Relevant Role ◽  
Skin Conditions ◽  
Autoimmune Blistering Diseases

Dermatitis herpetiformis (DH), bullous pemphigoid (BP), and pemphigus vulgaris (PV) are autoimmune bullous skin conditions with eosinophilic and neutrophilic infiltrations. While cytokines are crucial for the affinity and activation of different leukocyte cells in the inflammation and blister formation, there are no studies concerning a role of IL-36. The goal of the study was to analyze whether interleukin 36 is involved in pathogenesis of DH, BP, and PV. And the second aim of the study was the estimation of correlation between IL-36 and IL-17 and titers of specific antibodies in these diseases. Expression of IL-36 and IL-17 was detected in serum in all DH, BP, and PV samples. Serum levels of IL-36 and IL-17α were statistically higher in DH, BP, and PV groups as compared to the control group. IL-36α levels were statistically higher in DH patients, as compared to patients with PV and BP. Our results showed that IL-36 may be helpful in the diagnostic and monitoring of the activity of the disease. IL-36 may play a relevant role of enrolling eosinophils and neutrophils in DH, BP, and PV and finally provoke tissue injury.

Decreased serum levels of interleukin‐17, interleukin‐23, TGF ‐β in pemphigus vulgaris patients, and their association with disease phase

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Zeinab Gholibeigian ◽  
Maryam Izad ◽  
Maryam Daneshpazhooh ◽  
Hossein Mortazavi ◽  
Zahra Salehi ◽  
...  
Keyword(s):  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Interleukin 17 ◽  
Interleukin 23

scholarly journals Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Rodolfo Pessato Timoteo ◽  
Marcos Vinicius da Silva ◽  
Camila Botelho Miguel ◽  
Djalma Alexandre Alves Silva ◽  
Jonatas Da Silva Catarino ◽  
...  
Keyword(s):  
Immune Response ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Skin Lesions ◽  
Clinical Parameters ◽  
Cytokines And Chemokines ◽  
Th17 Cytokines ◽  
Control Disease ◽  
Desmoglein 3

Pemphigus vulgaris (PV) is an autoimmune disease characterized by the presence of IgG autoantibodies against desmoglein-3. Despite the variety of findings, the chemokine and cytokine profiles that characterize the immune response in the disease are still poorly explored. Thus, 20 PV patients and 20 controls were grouped according to gender, ethnicity, place of residence, and clinical parameters of the disease. Then, the levels of chemokines and of Th1/Th2/Th17/Treg/Th9/Th22-related cytokines were assessed in the serum. PV patients had higher levels of inflammatory Th1/Th17 cytokines (IFN-γ, IL-17, and IL-23), as well as higher levels of CXCL8 and reduced levels of Th1/Th2-related chemokines (IP-10 and CCL11). However, no differences in the levels of IL-2, IL-6, TNF-α, IL-1β, IL-4, IL-9, IL-12, TGF-β, IL-33, MCP-1, RANTES, and MIP-1α were found between PV patients and their control counterparts. Furthermore, PV patients with skin lesions had higher serum levels of IL-6 and CXCL8 when compared to PV patients without lesions. Taken together, our findings describe the role of cytokines and chemokines associated with Th1/Th17 immune response in PV patients. Finally, these data are important for better understanding of the immune aspects that control disease outcome, and they may also provide important information about why patients develop autoantibodies against desmogleins.

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