scholarly journals Production of tumor necrosis factor-α and interleukin-6 in whole blood stimulated by live Gram-negative and Gram-positive bacteria

1998 ◽  
Vol 4 (3) ◽  
pp. 129-134 ◽  
Author(s):  
Peter Kragsbjerg ◽  
Bo Söderquist ◽  
Hans Holmberg ◽  
Tomas Vikerfors ◽  
Dan Danielsson
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Whole Blood ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Prognostic serum tumor necrosis factor-α in paediatric patients with sepsis

2009 ◽  
Vol 3 (06) ◽  
pp. 437-441 ◽  
Author(s):  
Surinder Kumar ◽  
Meher Rizvi
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Geometric Mean ◽  
Gram Positive ◽  
Gram Negative ◽  
Paediatric Patients ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Objective: To study the association of tumor necrosis factor-α (TNF-α) in paediatric patients with different etiological agents and levels of sepsis. Methodology: Seventy-nine patients with sepsis were studied. Blood cultures, along with other relevant specimens, were processed for bacterial and fungal etiology. TNF-α was detected by enzyme immunoassay. Results: In total, 42 (53.2%) of the patients had a microbiologically documented cause for sepsis. Of the gram-negative bacilli, Escherichia coli was the most common isolate followed by Klebsiella pneumoniae. Enterobacter spp. Serratia marscecens as well as Citrobacter koseri. Streptococcus pneumoniae and Staphylococcus aureus predominated among the gram-positive cocci. Patients with a positive culture had significantly higher TNF-α levels than patients with a negative culture (70 pg/ml vs. 33 pg/ml p = 0.01). Patients with a pure gram-negative infection had significantly higher TNF-α levels than those with pure gram-positive infection (83 pg/ml vs.52 pg/ml). The geometric mean TNF-α concentrations in patients with severe sepsis and those with late septic shock were 47 pg/ml (range 5-2720) and 59 pg/ml (range 5-3310) respectively. Conclusion: TNF-α was significantly raised in culture-positive cases in general and in gram-negative infections in particular. It can be used as a surrogate marker of sepsis and aggressive treatment initiated in patients with elevated levels of TNF alpha.

Lymphocyte-Derived Cytokines Augment Macrophage Tumor Necrosis Factor-α and Interleukin-6 Secretion during Experimental Gram-Negative Bacterial Sepsis

1995 ◽  
Vol 58 (6) ◽  
pp. 739-745 ◽  
Author(s):  
Richard J. Battafarano ◽  
Sung K. Kim ◽  
Peter S. Dahlberg ◽  
Mitchell S. Farber ◽  
Craig A. Ratz ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Bacterial Sepsis ◽  
Gram Negative ◽  
Factor Α ◽  
Necrosis Factor

Monoclonal Antibody to Tumor Necrosis Factor-α Attenuates Plasma Interleukin-6 Levels in Porcine Gram-Negative Sepsis

1994 ◽  
Vol 57 (5) ◽  
pp. 625-631 ◽  
Author(s):  
Patrick G. Mullen ◽  
Bernard J. Fisher ◽  
Ciaran J. Walsh ◽  
Brian M. Susskind ◽  
Sandra K. Leeper-Woodford ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Gram Negative ◽  
Factor Α ◽  
Necrosis Factor

Tumor Necrosis Factor-α Hyper-Responsiveness to Endotoxin in Whole Blood Is Associated with Chronic Bronchitis in Farmers

2005 ◽  
Vol 10 (1) ◽  
pp. 39-44 ◽  
Author(s):  
G. Patrick Lambert ◽  
John R. Spurzem ◽  
Debra J. Romberger ◽  
Todd A. Wyatt ◽  
Elizabeth Lyden ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Chronic Bronchitis ◽  
Whole Blood ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals FRI0374 PLASMA LEVELS OF 14-3-3 PROTEIN, S100A8/S100A9-PROTEIN, INTERLEUKIN-6, INTERLEUKIN-18, INTERLEUKIN-4, INTERLEUKIN-17, INTERLEUKIN-1Β AND TUMOR NECROSIS FACTOR-Α IN CHRONIC NON-BACTERIAL OSTEOMYEILITIS AND NON-SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 784.3-784
Author(s):  
M. Kostik ◽  
M. Makhova ◽  
D. Kozlova ◽  
D. Vasilyev ◽  
L. Sorokina ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Immune Mediated ◽  
Factor Α ◽  
Necrosis Factor

Background:Chronic non-bacterial osteomyelitis (CNO) is an immune-mediated disease associated with cytokine dysbalance.Objectives:The aim of our study was to evaluate the cytokines levels in CNO and compare to juvenile idiopathic arthritis (JIA) – disease with immune-mediated mechanism.Methods:The diagnosis of CNO made with criteria, proposed by Jansson (2007, 2009), after the exclusion of other causes of bone disease [1]. We included 42 patients with NBO, 28 patients with non-systemic juvenile idiopathic arthritis (JIA). We evaluated plasma levels of 14-3-3 protein, S100A8/S100A9-protein, interleukine-6 (IL-6), interleukine-18 (IL-18), interleukine-4 (IL-4), interleukine-17 (IL-17), interleukine-1β (IL-1 β) and tumor necrosis factor-α (TNFα) in 2 groups by the ELISA. Statistical analysis was carried out with Statistica 10.0 software. We utilized descriptive statistics (Me; IQR), Mann-Whitney tests.Results:We have found differences in the proinflammatory biomarkers between CNO, JIA. Patients with NBO had lower levels of studied cytokines, exclude14-3-3-protein, S100A8/S100A9 and interleukin-6 compare to JIA patients (table 1).Table 1.Comparison the cytokine levels between CNO, JIA NParameterNBO (n=42)JIA (n=28)pHemoglobin, g/l112 (104; 124)120 (114.5; 126.0)0.02WBC x 109/l7.9 (7.0; 10.5)8.0 (6.7; 10.0)0.86PLT x 109/l347 (259; 408)336.5 (274.0; 390.5)0.98ESR. mm/h25.0 (9.0; 46.0)8.5 (2.5; 13.0)0.013CRP, mg/l6.1 (0.6; 2.4)1.8 (0.4; 11.9)0.02714-3-3, ng/ml21.4 (18.5; 27.1)19.9 (18.0; 27.8)0.77S100A8/S100A9, ng/ml5.9 (5.2; 6.5)5.9 (5.0; 6.2)0.76IL-6, ng/ml126,2 (112.8; 137.5)132.4 (117.4; 142.9)0.16IL-18, ng/ml270.1 (200.1; 316.1)388.3 (373.9; 405.1)0.0000001IL-4, ng/ml15.3 (11.5; 18.2)18.7 (16.2; 20.2)0.003IL-17, ng/ml83.1 (71.1; 97.3)99.2 (87.3; 115.8)0.003IL-1b, ng/ml47.4 (42.0; 51.3)70.8 (65.3; 73.6)0.0000001TNFa, ng/ml19.4 (17.8; 21.3)23.1 (20.2; 25.9)0.0006Conclusion:Patients with CNO had less proinflammatory activity then JIA patients, besides IL-6 and S100A8/S100A9. Further investigations required for finding new more precise biomarkers and finding possible molecular targets for treatment.This work supported by the Russian Foundation for Basic Research (grant № 18-515-57001)References:[1]Jansson AF, et al. Clinical score for nonbacterial osteitis in children and adults. Arthritis Rheum. 2009;60(4):1152-9.Disclosure of Interests:None declared

Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients

1993 ◽  
Vol 104 (5) ◽  
pp. 1492-1497 ◽  
Author(s):  
Baudouin Byl ◽  
Ingrid Roucloux ◽  
Alain Crusiaux ◽  
Etienne Dupont ◽  
Jaqugs Devière
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Cirrhotic Patients ◽  
Factor Α ◽  
Necrosis Factor
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