Parvovirus B19 infection: association with third-trimester intrauterine fetal death

Clinico-epidemiological characteristics of parvovirus В19 infection are presented. Especially dangerous is the virus for pregnant women in the first and second trimesters of pregnancy, as it can lead to spontaneous abortion, the development of non-immune dropsy or intrauterine fetal death. Infectious erythema is characterized by a bright erythema of the cheek skin — a symptom of «spanked» cheeks, a patchy-papular «lacy» rash on the skin of the trunk and extensor surfaces of the extremities, more common in children aged 4 to 10 years. Diagnosis of parvovirus infection B19 is based on the results of serological methods, PCR, detection of IgM, immunoblot IgM/IgG. A clinical case of infectious erythema in a girl of 5 years is described.

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Discordant Outcomes in a Case of Parvovirus B19 Transmission Into Both Dichorionic Twins

Twin Research and Human Genetics ◽

10.1375/twin.12.2.175 ◽

2009 ◽

Vol 12 (2) ◽

pp. 175-179 ◽

Cited By ~ 9

Author(s):

Monika Schiesser ◽

Consolato Sergi ◽

Martin Enders ◽

Holger Maul ◽

Paul Schnitzler

Keyword(s):

Twin Pregnancy ◽

Fetal Death ◽

Parvovirus B19 ◽

Clinical Signs ◽

Dna Amplification ◽

Intrauterine Fetal Death ◽

Viral Dna ◽

Vitro Fertilization ◽

Parvovirus B19 Infection

AbstractMaternal infection with parvovirus B19 during pregnancy can cause aplastic anemia in the fetus and may lead to nonimmune fetal hydrops and fetal demise. Twin pregnancies complicated by infection due to parvovirus B19 are very rare clinical events. We present a dichorionic, diamniotic, dizygotic twin pregnancy after in vitro fertilization with parvovirus B19 infection and viral transmission to both twins, but different outcomes. At 19 weeks gestation, hydrops fetalis was diagnosed for male twin A, female twin B did not show any abnormalities. At 22 weeks gestation an acute parvovirus B19 infection was detected and twin A was diagnosed with intrauterine fetal death (IUFD) by ultrasound at 23 weeks gestation. Viral DNA was detected in maternal blood as well as in placenta and liver tissue of this twin. Twin B was born at 35 weeks gestation asymptomatically and no signs of hydrops or other congenital anomalies but viral DNA was detected by PCR in serum. At the age of 2 years, both IgG titres against B19 and parvovirus DNA amplification copies were still positive in plasma of the surviving twin, but no clinical signs were detectable. It is remarkable that both twins were infected with parvovirus B19 early in pregnancy but showed a discordant clinical outcome. Our case report describes the rare occurrence of an intrauterine fetal death (IUFD) of one twin and the asymptomatic infection of the other in a twin pregnancy.

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Expectant Management Leading to Successful Vaginal Delivery following Intrauterine Fetal Death in a Woman with an Incarcerated Uterus

Case Reports in Obstetrics and Gynecology ◽

10.1155/2017/2635275 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Masafumi Yamamoto ◽

Mio Takami ◽

Ryosuke Shindo ◽

Michi Kasai ◽

Shigeru Aoki

Keyword(s):

Vaginal Delivery ◽

Fetal Death ◽

Expectant Management ◽

Intrauterine Fetal Death ◽

Third Trimester ◽

Spontaneous Reduction

Expectant management leads to successful vaginal delivery following intrauterine fetal death in a woman with an incarcerated uterus. Management of intrauterine fetal death in the second or third trimester of pregnancy in women with an incarcerated uterus is challenging. We report a case of successful vaginal delivery following intrauterine fetal death by expectant management in a woman with an incarcerated uterus. In cases of intrauterine fetal death in women with an incarcerated uterus, vaginal delivery may be possible if the incarceration is successfully reduced. If the reduction is impossible, expectant management can reduce uterine retroversion, thereby leading to spontaneous reduction of the incarcerated uterus. Thereafter, vaginal delivery may be possible.

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Revised Clinical Presentation of Parvovirus B19–Associated Intrauterine Fetal Death

Clinical Infectious Diseases ◽

10.1086/342575 ◽

2002 ◽

Vol 35 (9) ◽

pp. 1032-1038 ◽

Cited By ~ 38

Author(s):

Oscar Norbeck ◽

Nikos Papadogiannakis ◽

Karin Petersson ◽

Taha Hirbod ◽

Kristina Broliden ◽

...

Keyword(s):

Fetal Death ◽

Clinical Presentation ◽

Parvovirus B19 ◽

Intrauterine Fetal Death

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Low Dose Vaginal Misoprostol in the Management of Women with Intrauterine Fetal Death

Clinical Medicine Insights Women s Health ◽

10.4137/cmwh.s5797 ◽

2010 ◽

Vol 3 ◽

pp. CMWH.S5797

Author(s):

M.N. El-Gharib ◽

M.T. El-Ebyary ◽

T.S. Alhawary ◽

S.H. Elshourbagy

Keyword(s):

Fetal Death ◽

Mean Value ◽

University Hospital ◽

Intrauterine Fetal Death ◽

Third Trimester ◽

Trimester Pregnancy ◽

Observational Cohort ◽

The Mean ◽

Vaginal Misoprostol ◽

Duration Of Gestation

Objectives The study was conducted to assess the effectiveness and side effects of vaginal misoprostol (Vagiprost® tablet) in termination of second and third trimester pregnancy complicated with intrauterine fetal death. Design A prospective observational cohort study. Setting Tanta University Hospital. Patients The study was carried out on 324 women with fetal demise in the second and third trimesters. Cases were collected during the period from January 2008 to December 2009. Intervention All patients were subjected to history taking, physical examination, Bishop Scoring. Application of 25 μg misoprostol in the posterior fornix of the vagina, this will be repeated every 4 hours over 24 hours. The adverse effects, progress, and outcomes were assessed. Results the success rate was 90% and 45% in women with third and second trimesters respectively. The mean induction-termination interval was 8.95 ± 2.63 and 15.3 ± 5.37 hours for women with third and second trimesters respectively. The induction termination interval correlated negatively with the duration of gestation. Approximately, 90% of second trimester and 55% of third trimester women required oxytocin augmentation. The mean value of total required dose of misoprostol was 166.3 ± 7.5 and 120 ± 28.79 μg for women with second and third trimesters respectively. Conclusion Vagiprost appears to be a safe, effective, practical, and inexpensive method for termination of third trimester pregnancy complicated with of intrauterine fetal death (IUFD), its effects increase with parity and duration of gestation.

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