The role of tissue factor and tissue factor pathway inhibitor in health and disease states

2009 ◽  
Vol 19 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Louis A. DelGiudice ◽  
George A. White
Keyword(s):  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Disease States ◽  
Health And Disease ◽  
Tissue Factor Pathway

Factor Xa Enhances the Binding of Tissue Factor Pathway Inhibitor to Acidic Phospholipids

1996 ◽  
Vol 75 (05) ◽  
pp. 796-800 ◽  
Author(s):  
Sanne Valentin ◽  
Inger Schousboe
Keyword(s):  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Factor Xa ◽  
Microtitre Plate ◽  
C Terminus ◽  
Microtitre Plate Assay ◽  
Kunitz Domain ◽  
Tissue Factor Pathway ◽  
Acidic Phospholipids

SummaryIn the present study, the interaction between tissue factor pathway inhibitor (TFPI) and phospholipids has been characterized using a microtitre plate assay. TFPI was shown to bind calcium-independently to an acidic phospholipid surface composed of phosphatidylserine, but not a surface composed of the neutral phosphatidylcholine. The interaction was demonstrated to be dependent on the presence of the TFPI C-terminus. The presence of heparin (1 U/ml, unfractionated) was able to significantly reduce the binding of TFPI to phospholipid. The interaction of TFPI with phosphatidylserine was significantly decreased in the presence of calcium, but this was counteracted, and even enhanced, following complex formation of TFPI with factor Xa prior to incubation with the phospholipid surface. Moreover, a TFPI variant, not containing the third Kunitz domain and the C-terminus, was unable to bind to phospholipid. However, following the formation of a TFPI/factor Xa-complex this TFPI variant was capable of interacting with the phospholipid surface. This indicates that the role of factor Xa as a TFPI cofactor, at least in part, is to mediate the binding of TFPI to the phospholipid surface.

Role of GATA Motifs in Tissue Factor Pathway Inhibitor Gene Expression in Malignant Cells

2001 ◽  
Vol 101 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Madhu S. Bajaj ◽  
Darren R. Tyson ◽  
Sarah A. Steer ◽  
Mohan N. Kuppuswamy
Keyword(s):  
Gene Expression ◽  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Malignant Cells ◽  
Tissue Factor Pathway ◽  
Inhibitor Gene

The role of tissue factor pathway inhibitor in atherosclerosis and arterial thrombosis

Blood Reviews ◽  
2013 ◽  
Vol 27 (3) ◽  
pp. 119-132 ◽  
Author(s):  
Kristien Winckers ◽  
Hugo ten Cate ◽  
Tilman M. Hackeng
Keyword(s):  
Tissue Factor ◽  
Arterial Thrombosis ◽  
Tissue Factor Pathway Inhibitor ◽  
Tissue Factor Pathway

The Role of Tissue Factor Pathway Inhibitor in Tumor Growth and Metastasis

2007 ◽  
Vol 33 (7) ◽  
pp. 643-652 ◽  
Author(s):  
Ali Amirkhosravi ◽  
Todd Meyer ◽  
Mildred Amaya ◽  
Monica Davila ◽  
Shaker Mousa ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Tissue Factor Pathway ◽  
Tumor Growth And Metastasis

The Role of Tissue Factor Pathway Inhibitor-2 in Cancer Biology

2007 ◽  
Vol 33 (7) ◽  
pp. 653-659 ◽  
Author(s):  
Ewa Sierko ◽  
Marek Wojtukiewicz ◽  
Walter Kisiel
Keyword(s):  
Tissue Factor ◽  
Cancer Biology ◽  
Tissue Factor Pathway Inhibitor ◽  
Tissue Factor Pathway
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