Lidocaine/Monoethylglycinexylidide Test, Galactose Elimination Test, and Sorbitol Elimination Test for Metabolic Assessment of Liver Cell Bioreactors

2010 ◽  
Vol 34 (6) ◽  
pp. 462-472 ◽  
Author(s):  
Jörg C. Gerlach ◽  
Candace Brayfield ◽  
Gero Puhl ◽  
Reiner Borneman ◽  
Christian Müller ◽  
...  
Author(s):  
Robert R. Cardell

Hypophysectomy of the rat renders this animal deficient in the hormones of the anterior pituitary gland, thus causing many primary and secondary hormonal effects on basic liver functions. Biochemical studies of these alterations in the rat liver cell are quite extensive; however, relatively few morphological observations on such cells have been recorded. Because the available biochemical information was derived mostly from disrupted and fractionated liver cells, it seemed desirable to examine the problem with the techniques of electron microscopy in order to see what changes are apparent in the intact liver cell after hypophysectomy. Accordingly, liver cells from rats which had been hypophysectomized 5-120 days before sacrifice were studied. Sham-operated rats served as controls and both hypophysectomized and control rats were fasted 15 hours before sacrifice.


1959 ◽  
Vol 37 (6) ◽  
pp. 760-765 ◽  
Author(s):  
S.W. Berkheiser

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  

2018 ◽  
Vol 56 (08) ◽  
pp. e251-e251
Author(s):  
M Han ◽  
ZC Nwosu ◽  
MP Ebert ◽  
S Hammad ◽  
C Meyer ◽  
...  
Keyword(s):  

2004 ◽  
Vol 51 (3) ◽  
pp. 317
Author(s):  
Hyun Jun Choi ◽  
Jun Hyun Yun ◽  
Ji Hyeo Choi ◽  
Ju Hyun Im ◽  
Se Jong Kim ◽  
...  

1969 ◽  
Vol 62 (3) ◽  
pp. 468-476 ◽  
Author(s):  
Jeanine Guidollet ◽  
Pierre Louisot

ABSTRACT Corticosteroid-binding activity (transcortin) was investigated at the subcellular level of the rat liver cell: it was located exclusively in the cell sap, and not on the ribosomes or membranes. Oestrogens were found to increase the biological activity of this glycoprotein (corticosterone binding) in the plasma and in the cell sap. The isotopic activity of the glucidic fragments of glycoprotein (after incorporation of 14C-D-glucosamine), however, remained constant or decreased in the specific subcellular sites at which they were incorporated (membranes and cell sap). This absence of correlation between these two results is not in agreement with an induction of transcortin synthesis by oestrogens, but in favour of an activation of normally masked molecular sites.


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