Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

CNS Neuroscience & Therapeutics ◽

10.1111/j.1755-5949.2008.00037.x ◽

2008 ◽

Vol 14 (1) ◽

pp. 65-82 ◽

Cited By ~ 59

Author(s):

Karin R. Tietje ◽

David J. Anderson ◽

R. Scott Bitner ◽

Eric A. Blomme ◽

Paul J. Brackemeyer ◽

...

Keyword(s):

Broad Spectrum ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

In vivo characterization of the co-administration of α4β2 neuronal nicotinic receptor agonist and positive allosteric modulator in experimental pain in rats

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.06.082 ◽

2009 ◽

Vol 78 (7) ◽

pp. 920

Author(s):

Chang Z. Zhu ◽

Chih-liang Chin ◽

Chengmin Zhong ◽

Joe Mikusa ◽

Prasant Chandran ◽

...

Keyword(s):

Nicotinic Receptor ◽

Receptor Agonist ◽

Experimental Pain ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

In Vivo Characterization

P2-477: Evidence for broad spectrum symptomatic efficacy across cognitive domains and potential for disease modification in Alzheimer's disease revealed by the novel alpha-7 neuronal nicotinic receptor agonist A-582941

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.1555 ◽

2008 ◽

Vol 4 ◽

pp. T514-T514

Author(s):

Murali Gopalakrishnan ◽

David Anderson ◽

William Bunnelle ◽

Clark Briggs ◽

Jerry Buccafusco ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Broad Spectrum ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

The Novel ◽

Disease Modification ◽

Cognitive Domains ◽

Alpha 7

Effects of TC-1734 (AZD3480), a selective neuronal nicotinic receptor agonist, on cognitive performance and the EEG of young healthy male volunteers

Psychopharmacology ◽

10.1007/s00213-006-0675-x ◽

2007 ◽

Vol 191 (4) ◽

pp. 919-929 ◽

Cited By ~ 73

Author(s):

G. Dunbar ◽

P. H. Boeijinga ◽

A. Demazières ◽

C. Cisterni ◽

R. Kuchibhatla ◽

...

Keyword(s):

Cognitive Performance ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

Healthy Male ◽

Healthy Male Volunteers ◽

Male Volunteers

Protective effects of α7 neuronal nicotinic receptor agonist on glutamate-induced neurotoxicity in cultured cortical neurons.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)36924-0 ◽

1996 ◽

Vol 71 ◽

pp. 171

Author(s):

Satoshi Kaneko ◽

Takehiko Maeda ◽

Shuji Kaneko ◽

Akinori Akaike ◽

Shun Shimohama ◽

...

Keyword(s):

Cortical Neurons ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

Protective Effects ◽

Cultured Cortical Neurons

In vitro binding characteristics of [3H]AZ11637326, a novel α7-selective neuronal nicotinic receptor agonist radioligand

European Journal of Pharmacology ◽

10.1016/j.ejphar.2010.07.035 ◽

2010 ◽

Vol 645 (1-3) ◽

pp. 63-69 ◽

Cited By ~ 12

Author(s):

John C. Gordon ◽

Eifion Phillips ◽

David A. Gurley ◽

J. Richard Heys ◽

Lois Ann Lazor ◽

...

Keyword(s):

Nicotinic Receptor ◽

Receptor Agonist ◽

Binding Characteristics ◽

In Vitro Binding ◽

Vitro Binding

Efficacy and safety of the α4β2 neuronal nicotinic receptor agonist ABT-894 in patients with diabetic peripheral neuropathic pain

Pain ◽

10.1016/j.pain.2012.01.009 ◽

2012 ◽

Vol 153 (4) ◽

pp. 862-868 ◽

Cited By ~ 35

Author(s):

Michael C. Rowbotham ◽

Armen Arslanian ◽

Wolfram Nothaft ◽

Rachel W. Duan ◽

Andrea E. Best ◽

...

Keyword(s):

Neuropathic Pain ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

Efficacy And Safety ◽

Peripheral Neuropathic Pain ◽

[3H]A-585539 [(1S,4S)-2,2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a Novel High-Affinity α7 Neuronal Nicotinic Receptor Agonist: Radioligand Binding Characterization to Rat and Human Brain

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.130062 ◽

2007 ◽

Vol 324 (1) ◽

pp. 179-187 ◽

Cited By ~ 47

Author(s):

David J. Anderson ◽

William Bunnelle ◽

Bruce Surber ◽

Jia Du ◽

Carol Surowy ◽

...

Keyword(s):

Human Brain ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

Radioligand Binding ◽

High Affinity

In vitro and in vivo characterization of TC-1827, a novel brain?4?2 nicotinic receptor agonist with pro-cognitive activity

Drug Development Research ◽

10.1002/ddr.10352 ◽

2004 ◽

Vol 62 (1) ◽

pp. 26-40 ◽

Cited By ~ 12

Author(s):

Georg Andrees Bohme ◽

Sharon R. Letchworth ◽

Odile Piot-Grosjean ◽

Gregory J. Gatto ◽

Marie-Carmen Obinu ◽

...

Keyword(s):

Nicotinic Receptor ◽

Receptor Agonist ◽

Cognitive Activity ◽

In Vivo Characterization

Corrigendum to “Antinociceptive activity of α4β2* neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain” [Eur. J. Pharmacol. 668 (2011) 155–162]

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.10.014 ◽

2011 ◽

Vol 673 (1-3) ◽

pp. 101

Author(s):

Ramakrishna Nirogi ◽

Pradeep Jayarajan ◽

Renny Abraham ◽

Dhanalakshmi Shanmuganathan ◽

Mohammed Abdul Rasheed ◽

...

Keyword(s):

Inflammatory Pain ◽

Nicotinic Receptor ◽

Receptor Agonist ◽

Experimental Models ◽

Antinociceptive Activity ◽