Effect of Interictal Epileptiform Discharges on Nocturnal Plasma Prolactin Concentrations in Epileptic Patients with Complex Partial Seizures

Epilepsia ◽  
1986 ◽  
Vol 27 (6) ◽  
pp. 724-728 ◽  
Author(s):  
Majid Molaie ◽  
Antonio Culebras ◽  
Myron Miller
Keyword(s):  
Plasma Prolactin ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Epileptiform Discharges ◽  
Interictal Epileptiform Discharges ◽  
Epileptic Patients

scholarly journals Attentional disorders in patients with complex partial epilepsy

2003 ◽  
Vol 61 (2B) ◽  
pp. 335-338 ◽  
Author(s):  
Florindo Stella ◽  
Jayme Antunes Maciel
Keyword(s):  
State University ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Wrong Response ◽  
Significant Difference ◽  
Complex Partial Epilepsy ◽  
Epileptic Patients ◽  
Attentional Disorders ◽  
Comparative Group

A study of concentrated attention patterns in epileptic patients was conducted with the objectives: characterization of the patients' epileptic condition; assessment of the concentrated attention levels in epileptic and nonepileptic individuals; comparison of the attention levels of the two groups. An evaluation was performed of 50 adult outpatients with complex partial seizures and 20 non-epileptic individuals (comparative group) at the Neuroepilepsy Ambulatory Unit, State University of Campinas SP, Brazil. METHOD: characterization of seizure types, frequency and duration; concentrated attention assessment (Concentrated Attention Test - Toulouse-Piéron); comparison of the epileptic with non-epileptic individuals. RESULTS: A statistically significant difference was observed between the groups with regard to Correct Response, Wrong Response and No Response. A difference was observed in relation to Time, but it was statistically insignificant. The epileptic patients presented inferior cognitive performance in relation to concentrated attention when compared with the non-epileptic individuals, findings compatible with the clinical complaints.

Nocturnal plasma prolactin rise in patients with complex partial seizures

1985 ◽  
Vol 18 (6) ◽  
pp. 719-722 ◽  
Author(s):  
Majid Molaie ◽  
Antonio Culebras ◽  
Myron Miller
Keyword(s):  
Plasma Prolactin ◽  
Partial Seizures ◽  
Complex Partial Seizures

Neuronal heterotopia with capillary penetration of neurons and cortical dysplasia in a patient with complex partial seizures

1993 ◽  
Vol 78 (4) ◽  
pp. 654-657 ◽  
Author(s):  
Venita Jay ◽  
Laurence E. Becker ◽  
Hiroshi Otsubo ◽  
Paul Hwang ◽  
Harold J. Hoffman ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe ◽  
Cortical Dysplasia ◽  
Neuronal Morphology ◽  
Partial Seizures ◽  
Left Temporal Lobe ◽  
Complex Partial Seizures ◽  
Epileptiform Discharges ◽  
Vascular Elements ◽  
Developmental Disturbance

✓ Unusual pathological findings were encountered in a temporal lobectomy specimen from a 9-year-old boy with intractable complex partial seizures. Magnetic resonance imaging revealed an enlarged left temporal lobe, with diffuse high signal intensity over the cortex and poor gray-white differentiation on T2-weighted imaging; single-photon emission computerized tomography showed decreased blood flow. Active epileptiform discharges were identified in the left temporal lobe with focal slow waves and generalized epileptiform paroxysms. Pathologically, the cortex revealed changes of focal cortical dysplasia with extensive disorganization of neuronal morphology, layering, and orientation as well as focal polymicrogyria. The cortical-white matter junction was indistinct with extensive neuronal heterotopias in the white matter. Large pale balloon cells akin to those seen in tuberous sclerosis were found scattered within the cortex and white matter. The most striking finding was that of a heterotopic nodule in the white matter, which revealed abnormal neurons with penetration of cell bodies by capillaries. Ultrastructurally, there were no degenerative changes in these neurons, and this unusual phenomenon is attributed to a developmental disturbance affecting neuronal, glial, and vascular elements.

scholarly journals 126 Incidence of dementia in elderly patients with epilepsy

2019 ◽  
Vol 90 (e7) ◽  
pp. A41.1-A41
Author(s):  
Viral Upadhyay ◽  
Aloysius Ng ◽  
Manori Wijayath
Keyword(s):  
Brain Mri ◽  
Good Control ◽  
List Type ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Epileptiform Discharges ◽  
History Of ◽  
Australian Bureau Of Statistics ◽  
Patients With Epilepsy ◽  
Incidence Of Dementia

IntroductionThe incidence of epilepsy is higher in patients with underlying dementia.1 The goal of the present study is to look at the incidence of dementia in patients presented to our epilepsy clinic and analyse electroencephalogram (EEG), imaging findings and response to antiepileptic drug (AED) in these individuals.MethodsA retrospective study was performed on patients presented to Nepean Hospital epilepsy clinic from 2015 to 2017. Multiple clinical parameters were obtained from electronic medical records.ResultsA total of 258 patients presented to the clinic, of which 38 patients were above the age of 65 years. 11 patients were excluded due to insufficient information or patients without any history of seizures. Out of the remaining 27 patients studied, nine patients (33%) had dementia including five patients (19%) with Alzheimer’s dementia. Sixteen patients (59%) experienced complex partial seizures. Brain MRI was performed in twenty one patients (78%). Sixteen patients (59%) had MRI-identified structural lesions including prior stroke or intracerebral haemorrhage. EEGs were performed in twenty patients (74%). Eight patients (40%) had abnormal EEG with one patient (5%) having epileptiform discharges, three patients (15%) having focal slowing and four patients (20%) having generalised slowing. Overall, nineteen patients (70%) were on AEDs with good control and four patients (15%) required more than one AED to achieve seizure control.ConclusionThe study showed that there is higher incidence of dementia in patients with epilepsy compared with general population.2 Most patients experience complex partial seizures and can be adequately controlled on single AED.ReferencesRao S, Dove G, Cascino G, Petersen R. Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome. Epilepsy & Behavior 2009, 14(1), pp.118–120.ABS (Australian Bureau of Statistics) 2016, Life Tables, States, Territories and Australia, 2013–2015, cat. no. 3302.0.55.001, ABS, Canberra

Research Diagnostic Criteria (RDC) Mental Disorder and Self-Reported Symptoms in Outpatients with Complex Partial Seizures (CPS)

1988 ◽  
Vol 17 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Giulia I. Perini
Keyword(s):  
Diagnostic Criteria ◽  
Cognitive Deficits ◽  
Cognitive State ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Symptoms Of Depression ◽  
Epileptic Patients ◽  
State And Trait Anxiety ◽  
State Examination ◽  
Research Diagnostic Criteria

Fifteen outpatients with complex partial seizures (CPS) were investigated to assess the presence and severity of affective disorders, anxiety, and cognitive deficits. Forty percent of patients met the criteria for an affective disorder according to Research Diagnostic Criteria (RDC). Patients scored significantly higher than controls on the Beck Depression Inventory ( p < 0.001), on the State and Trait Anxiety Inventory ( p < 0.01, p < 0.05), on the Symptom Questionnaire scales for anxiety ( p < 0.005), depression ( p < 0.01), and somatization ( p < 0.01). They also scored significantly lower than controls on the Mini-Mental State Examination for grading cognitive state ( p < 0.05). Epileptic patients with RDC diagnosis of depression reported significantly more symptoms of depression, anxiety, somatization, and less sociability and trustfulness than epileptic patients without concurrent mental disorders. Implications of these results are discussed.

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