New evidence on the potential role of the metabolic syndrome as a risk factor for venous thromboembolism

SummaryThe role of antiprothrombin (aPT) antibodies in the development of venous thromboembolism (VTE) is still uncertain. The aim of this study was to evaluate the potential role of aPT antibodies in the development of recurrent thromboembolism. Out of 236 consecutive symptomatic patients with an episode of acute VTE, antiphospholipid antibodies were found in 85 (36.0%), of whom 24 were carriers of aPT antibodies (10.2% of the entire cohort). A history of previous thromboembolism was identified in 56 patients (23.7%). The prevalence of previous thromboembolism was significantly higher in carriers than in non-carriers of antiphospholipid antibodies (OR=2.4; 95% CI, 1.3 to 4.4). Of the 24 patients with aPT antibodies, 12 had a history of previous thromboembolism. In a multivariate logistic regression analysis, in which the other categories of antiphospholipid antibodies were taken into account, as well as the patient’s age, sex, and the modality of clinical presentation, it was found that the presence of aPT antibodies was significantly associated with the prevalence of prior thromboembolism (OR=3.3; 95% CI, 1.3 to 8.6). Since aPT antibodies are more commonly identifiable in patients with multiple thrombotic episodes, they are a likely risk factor for recurrent thromboembolism.

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Etiology of the Metabolic Syndrome: Potential Role of Insulin Resistance, Leptin Resistance, and Other Players

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1999.tb07783.x ◽

1999 ◽

Vol 892 (1 THE METABOLIC) ◽

pp. 25-44 ◽

Cited By ~ 141

Author(s):

P. ZIMMET ◽

E. J. BOYKO ◽

G. R. COLLIER ◽

M. COURTEN

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Potential Role ◽

Leptin Resistance ◽

The Metabolic Syndrome

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Growth hormone and IGFBP-3 but not IGF-1 are independent predictors of insulin sensitivity in healthy subjects: on the role of hGH in the metabolic syndrome

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2006-933074 ◽

2006 ◽

Vol 114 (S 1) ◽

Author(s):

MA Arafat ◽

F Perschel ◽

C Schöfl ◽

M Weickert ◽

J Purschwitz ◽

...

Keyword(s):

Metabolic Syndrome ◽

Growth Hormone ◽

Insulin Sensitivity ◽

Healthy Subjects ◽

The Metabolic Syndrome ◽

Igfbp 3

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Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2004-03 ◽

2020 ◽

pp. 23-32

Author(s):

Elena Korneeva ◽

Mikhail Voevoda ◽

Sergey Semaev ◽

Vladimir Maksimov

Keyword(s):

Metabolic Syndrome ◽

High Risk ◽

Arterial Hypertension ◽

Genetic Factors ◽

Young Patients ◽

Integrin Αiibβ3 ◽

Ace Gene ◽

The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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The Potential Role of Antioxidants in Metabolic Syndrome

Current Pharmaceutical Design ◽

10.2174/1381612822666151209152352 ◽

2016 ◽

Vol 22 (7) ◽

pp. 859-869 ◽

Cited By ~ 34

Author(s):

Bianca Martins Gregório ◽

Diogo Benchimol De Souza ◽

Fernanda Amorim de Morais Nascimento ◽

Leonardo Matta ◽

Caroline Fernandes-Santos

Keyword(s):

Metabolic Syndrome ◽

Potential Role

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