Role of genetic factors in the development of hypertension in young patients with metabolic syndrome
2020 ◽
pp. 23-32
Keyword(s):
Ace Gene
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Results of the study related to polymorphism of ACE gene (rs1799752), integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).
Keyword(s):
2005 ◽
Vol 12
(3)
◽
pp. 172
Keyword(s):
2007 ◽
Vol 10
(4)
◽
pp. 204-209
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2007 ◽
Vol 47
(5)
◽
pp. 642-652
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2019 ◽
Vol 9
(5-s)
◽
pp. 167-169