scholarly journals MEIOTIC DRIVE IN NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. III. POPULATIONAL IMPLICATIONS OF THE SEGREGATION-DISTORTER LOCUS,

Evolution ◽  
1960 ◽  
Vol 14 (4) ◽  
pp. 433-444
Author(s):  
Yuichiro Hiraizumi ◽  
L. Sandler ◽  
James F. Crow
Keyword(s):  
Drosophila Melanogaster ◽  
Natural Populations ◽  
Meiotic Drive ◽  
Segregation Distorter ◽  
Distorter Locus

scholarly journals Rapid Evolution of a Coadapted Gene Complex: Evidence From the Segregation Distorter (SD) System of Meiotic Drive in Drosophila melanogaster

Genetics ◽  
1996 ◽  
Vol 143 (4) ◽  
pp. 1675-1688 ◽  
Author(s):  
Michael F Palopoli ◽  
Chung-I Wu
Keyword(s):  
Drosophila Melanogaster ◽  
Rapid Evolution ◽  
Natural Populations ◽  
Meiotic Drive ◽  
Pericentromeric Region ◽  
Genomic Region ◽  
Gene Complex ◽  
Segregation Distorter ◽  
Normal Homologue ◽  
Coadapted Gene Complex

Abstract Segregation Distorter (SD) is a system of meiotic drive found in natural populations of Drosophila melanogaster. Males heterozygous for an SD second chromosome and a normal homologue (SD  +) produce predominantly SD-bearing sperm. The coadapted gene complex responsible for this transmission advantage spans the second chromosome centromere, consisting of three major and several minor interacting loci. To investigate the evolutionary history of this system, we surveyed levels of polymorphism and divergence at six genes that together encompass this pericentromeric region and span seven map units. Interestingly, there was no discernible divergence between SD and SD  + chromosomes for any of these molecular markers. Furthermore, SD chromosomes harbored much less polymorphism than did SD  + chromosomes. The results suggest that the SD system evolved recently, swept to appreciable frequencies worldwide, and carried with it the entire second chromosome centromeric region (roughly 10% of the genome). Despite its well-documented genetic complexity, this coadapted system appears to have evolved on a time scale that is much shorter than can be gauged using nucleotide substitution data. Finally, the large genomic region hitchhiking with SD indicates that a multilocus, epistatically selected system could affect the levels of DNA polymorphism observed in regions of reduced recombination.

MEIOTIC DRIVE IN NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. IX. SUPPRESSORS OF SEGREGATION DISTORTER IN WILD POPULATIONS

1970 ◽  
Vol 12 (3) ◽  
pp. 594-600 ◽  
Author(s):  
D. L. Hartl
Keyword(s):  
Drosophila Melanogaster ◽  
Japanese Population ◽  
Autosomal Dominant ◽  
Natural Populations ◽  
Meiotic Drive ◽  
Wild Populations ◽  
Segregation Distorter ◽  
The Difference

A population of Drosophila melanogaster in Madison, Wisconsin, has been screened for suppressors of segregation distorter (SD), an autosomal meiotic drive element found in the same population. Three kinds of suppressors were tested for: (1) Y-linked suppressors, none were found, (2) X-linked suppressors, whose frequency was found to be 85%, and (3) autosomal dominant suppressors, which occur in 45% of autosome complements.The frequency of X-linked suppressors is comparable to that found in a Japanese population; autosomal suppressors are much more frequent in Madison than in Japan (Katoaka, 1967). The similarity in the frequency of sex-linked suppressors may result from the meiotic drive shown by the suppressor-X itself; the difference in the frequency of autosomal dominant suppressors is possibly related to a higher frequency of SD itself in the Madison population.

Functional identification of the Segregation distorter locus of Drosophila melanogaster by germline transformation.

Genetics ◽  
1994 ◽  
Vol 137 (1) ◽  
pp. 201-209 ◽  
Author(s):  
J R McLean ◽  
C J Merrill ◽  
P A Powers ◽  
B Ganetzky
Keyword(s):  
Drosophila Melanogaster ◽  
Chromosome Segregation ◽  
Genomic Dna ◽  
Tandem Duplication ◽  
Meiotic Drive ◽  
Wild Type ◽  
Functional Identification ◽  
Germline Transformation ◽  
Segregation Distorter ◽  
Distorter Locus

Abstract Segregation Distorter (SD) is a meiotic drive system in D. melanogaster that results in the failure of SD/SD+ males to transmit SD+ homologs owing to the induced dysfunction of spermatids carrying the normal chromosome. Segregation distorter (Sd), the gene primarily responsible for this distorted transmission, is associated with a novel 12-kb restriction fragment containing a tandem duplication of a 5-kb wild-type segment of genomic DNA. When introduced into appropriate genetic backgrounds by germline transformation, this 12-kb fragment causes full levels of distortion and directs the expression of an SD-specific 4-kb transcript. Transformants that have lost part of this segment are unable to cause distortion and do not express the 4-kb transcript. These results identify the tandem duplication as Sd.

scholarly journals MULTIPLE MEIOTIC DRIVE SYSTEMS IN THE DROSOPHILA MELANOGASTER MALE

Genetics ◽  
1972 ◽  
Vol 72 (1) ◽  
pp. 105-115
Author(s):  
George L Gabor Miklos ◽  
Armon F Yanders ◽  
W J Peacock
Keyword(s):  
Drosophila Melanogaster ◽  
Survival Probability ◽  
Sex Chromosome ◽  
Meiotic Drive ◽  
The Other ◽  
Segregation Distorter ◽  
Two Systems ◽  
Combined Action ◽  
Drive Systems

ABSTRACT The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc4sc8 has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc4sc8 are against each other, there is no detectable interaction. Each system is apparently oblivious to the presence of the other, gametes being produced according to independence expectations. However when the affected chromosomes are at the same meiotic pole an interaction occurs; the survival probability of the gamete containing both distorted chromosomal products is increased, rather than being decreased by the combined action of two systems.

scholarly journals Variation in Y Chromosome Segregation in Natural Populations of Drosophila melanogaster

Genetics ◽  
1987 ◽  
Vol 115 (1) ◽  
pp. 143-151
Author(s):  
Andrew G Clark
Keyword(s):  
Drosophila Melanogaster ◽  
Y Chromosome ◽  
Chromosome Segregation ◽  
Significant Variation ◽  
Natural Populations ◽  
Meiotic Drive ◽  
Adult Offspring ◽  
Functional Variation ◽  
Y Chromosomes ◽  
Geographic Origins

ABSTRACT Functional variation among Y chromosomes in natural populations of Drosophila melanogaster was assayed by a segregation study. A total of 36 Y chromosomes was extracted and ten generations of replacement backcrossing yielded stocks with Y chromosomes in two different genetic backgrounds. Eleven of the Y chromosomes were from diverse geographic origins, and the remaining 25 were from locally captured flies. Segregation of sexes in adult offspring was scored for the four possible crosses among the two backgrounds with each Y chromosome. Although the design confounds meiotic drive and effects on viability, statistical partitioning of these effects reveals significant variation among lines in Y chromosome segregation. Results are discussed in regards to models of Y-linked segregation and viability effects, which suggest that Y-linked adaptive polymorphism is unlikely.

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