A MODEL FOR THE EVOLUTION OF ASYMMETRICAL MALE HYBRID STERILITY AND ITS IMPLICATIONS FOR SPECIATION

ABSTRACT The genetic basis of hybrid sterility has been investigated in backcross segmental hybrids between two sibling species, Drosophila buzzatii and D. serido. Asynapsis of homologous bands in hybrid polytene chromosomes has been used to identify the D. serido chromosome segments introgressed into the D. buzzatti genome. All the investigated chromosomes contain male sterility factors. For autosomes, sterility is produced when an introgressed D. serido chromosome segment, or combination of segments, reaches a minimum size. On the other hand, any introgressed X chromosome segment from D. serido, irrespective of its size, produces either male hybrid sterility or inviability.

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Genetics of morphological differences and hybrid sterility between Drosophila sechellia and its relatives

Genetics Research ◽

10.1017/s0016672300029177 ◽

1991 ◽

Vol 57 (2) ◽

pp. 113-122 ◽

Cited By ~ 50

Author(s):

Jerry A. Coyne ◽

John Rux ◽

Jean R. David

Keyword(s):

Genetic Analysis ◽

X Chromosome ◽

Sibling Species ◽

Male Genitalia ◽

Hybrid Sterility ◽

Drosophila Sechellia ◽

Ovariole Number ◽

The Difference ◽

Male Hybrid ◽

Morphological Differences

SummaryWe conducted classical genetic analysis of the difference in male genitalia and hybrid sterility between the island-dwelling sibling species Drosophila sechellia and D. mauritiana. At least two loci (one on each autosome) are responsible for the genital difference, with the X chromosome having no significant effect. In contrast, male hybrid sterility is caused by at least four gene loci distributed among all major chromosomes, with those on the X chromosome having the largest effect.We also show that the large difference in ovariole number between D. sechellia and its mainland relative D. simulans is due to at least two gene substitutions, one on each major autosome. The X and the left arm of the second chromosome, however, have no significant effect on the character. This implies that the evolution of reduced ovariole number involved relatively few gene substitutions.These results extend previous findings that morphological differences between Drosophila species are caused by genes distributed among all chromosomes, while hybrid sterility and inviability are due primarily to X-linked genes. Because strong X-effects on male sterility have been found in all three pairwise hybridizations among D. simulans, D. sechellia and D. mauritiana, these effects must have evolved at least twice independently.

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Cross-species Y chromosome function between malaria vectors of the Anopheles gambiae species complex

10.1101/151894 ◽

2017 ◽

Cited By ~ 1

Author(s):

Federica Bernardini ◽

Roberto Galizi ◽

Mariana Wunderlich ◽

Chrysanthi Taxiarchi ◽

Nace Kranjc ◽

...

Keyword(s):

Anopheles Gambiae ◽

Y Chromosome ◽

Hybrid Sterility ◽

Substantial Reduction ◽

Direct Consequence ◽

Malaria Vectors ◽

Evolutionary Divergence ◽

Male Mating ◽

Gambiae Complex ◽

Male Hybrid

AbstractY chromosome function, structure and evolution is poorly understood in many species including the Anopheles genus of mosquitoes, an emerging model system for studying speciation that also represents the major vectors of malaria. While the Anopheline Y had previously been implicated in male mating behavior, recent data from the Anopheles gambiae complex suggests that, apart from the putative primary sex-determiner, no other genes are conserved on the Y. Studying the functional basis of the evolutionary divergence of the Y chromosome in the gambiae complex is complicated by complete F1 male hybrid sterility. Here we used an F1xF0 crossing scheme to overcome a severe bottleneck of male hybrid incompatibilities and enabled us to experimentally purify a genetically labelled A. gambiae Y chromosome in an A. arabiensis background. Whole genome sequencing confirmed that the A. gambiae Y retained its original sequence content in the A. arabiensis genomic background. In contrast to comparable experiments in Drosophila, we find that the presence of a heterospecific Y chromosome has no significant effect on the expression of A. arabiensis genes and transcriptional differences can be explained almost exclusively as a direct consequence of transcripts arising from sequence elements present on the A. gambiae Y chromosome itself. We find that Y hybrids show no obvious fertility defects and no substantial reduction in male competitiveness. Our results demonstrate that, despite their radically different structure, Y chromosomes of these two species of the gambiae complex that diverged an estimated 1.85Myr ago function interchangeably, thus indicating that the Y chromosome does not harbor loci contributing to hybrid incompatibility. Therefore, Y chromosome gene flow between members of the gambiae complex is possible even at their current level of divergence. Importantly, this also suggests that malaria control interventions based on sex-distorting Y drive would be transferable, whether intentionally or contingent, between the major malaria vector species.

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An autosomal factor from Drosophila arizonae restores normal spermatogenesis in Drosophila mojavensis males carrying the D. arizonae Y chromosome.

Genetics ◽

10.1093/genetics/134.1.309 ◽

1993 ◽

Vol 134 (1) ◽

pp. 309-318

Author(s):

A C Pantazidis ◽

V K Galanopoulos ◽

E Zouros

Keyword(s):

Y Chromosome ◽

Hybrid Sterility ◽

Light And Electron Microscopy ◽

Genetic Material ◽

Drosophila Mojavensis ◽

Fourth Chromosome ◽

Motility Factor ◽

Drosophila Arizonae ◽

Male Hybrid ◽

Necessary And Sufficient

Abstract Males of Drosophila mojavensis whose Y chromosome is replaced by the Y chromosome of the sibling species Drosophila arizonae are sterile. It is shown that genetic material from the fourth chromosome of D. arizonae is necessary and sufficient, in single dose, to restore fertility in these males. In introgression and mapping experiments this material segregates as a single Mendelian factor (sperm motility factor, SMF). Light and electron microscopy studies of spermatogenesis in D. mojavensis males whose Y chromosome is replaced by introgression with the Y chromosome of D. arizonae (these males are symbolized as mojYa) revealed postmeiotic abnormalities all of which are restored when the SMF of D. arizonae is co-introgressed (these males are symbolized as mojYaSMFa). The number of mature sperm per bundle in mojYaSMFa is slightly less than in pure D. mojavensis and is even smaller in males whose fertility is rescued by introgression of the entire fourth chromosome of D. arizonae. These observations establish an interspecific incompatibility between the Y chromosome and an autosomal factor (or more than one tightly linked factors) that can be useful for the study of the evolution of male hybrid sterility in Drosophila and the genetic control of spermatogenesis.

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Incompatibility Analysis of Male Hybrid Sterility in Two Drosophila Species: Lack of Evidence for Maternal, Cytoplasmic, or Transposable Element Effects

The American Naturalist ◽

10.1086/285781 ◽

1995 ◽

Vol 145 (6) ◽

pp. 1006-1014 ◽

Cited By ~ 2

Author(s):

George Goulielmos ◽

Eleftherios Zouros

Keyword(s):

Transposable Element ◽

Hybrid Sterility ◽

Drosophila Species ◽

Male Hybrid

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X-Chromosome involvement in male hybrid sterility from Glossina morsitans sub-species crosses

Heredity ◽

10.1038/hdy.1980.83 ◽

1980 ◽

Vol 45 (3) ◽

pp. 405-410 ◽

Cited By ~ 11

Author(s):

C F Curtis ◽

P A Langley ◽

M A Trewern

Keyword(s):

X Chromosome ◽

Hybrid Sterility ◽

Glossina Morsitans ◽

Male Hybrid

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MALE HYBRID STERILITY IN DROSOPHILA : INTERACTIONS BETWEEN AUTOSOMES AND SEX CHROMOSOMES IN CROSSES OF D. MOJAVENSIS AND D. ARIZONENSIS

Evolution ◽

10.1111/j.1558-5646.1988.tb04191.x ◽

1988 ◽

Vol 42 (6) ◽

pp. 1321-1331

Author(s):

E. Zouros ◽

K. Lofdahl ◽

P. A. Martin

Keyword(s):

Sex Chromosomes ◽

Hybrid Sterility ◽

Male Hybrid

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Inheritance of male hybrid sterility in the house musk shrew (Suncus murinus, Insectivora, Soricidae)

Genome ◽

10.1139/g98-085 ◽

1998 ◽

Vol 41 (6) ◽

pp. 825-831 ◽

Cited By ~ 5

Author(s):

Tatiana I Axenovich ◽

Margarita B Rogatcheva ◽

Sen-ichi Oda ◽

Pavel M Borodin

Keyword(s):

Male Sterility ◽

Segregation Analysis ◽

Hybrid Sterility ◽

Suncus Murinus ◽

Pedigree Data ◽

Musk Shrew ◽

Single Allele ◽

Male Hybrid ◽

Allele Combination

Two geographic races of the house musk shrew (Suncus murinus) were crossed and intercrossed in the laboratory. Many cases of male sterility were detected among the hybrids. Segregation analysis of the pedigree data showed that the inheritance of male sterility in interracial hybrids of S. murinus can be described within the framework of monogene polyallele model with sterility of a single allele combination. This model is similar if not identical to that proposed by Dobzhansky and Muller.Key words: hybrid sterility, segregation analysis, spermatogenesis, shrew, Suncus murinus.

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Male Hybrid Sterility in the Mule Duck is Associated with Meiotic Arrest in Primary Spermatocytes

The Journal of Poultry Science ◽

10.2141/jpsa.0130011 ◽

2013 ◽

Vol 50 (4) ◽

pp. 311-320 ◽

Cited By ~ 8

Author(s):

Fhamida B. Islam ◽

Satoshi Ishishita ◽

Yoshinobu Uno ◽

Md. Bazlur R. Mollah ◽

Kornsorn Srikulnath ◽

...

Keyword(s):

Hybrid Sterility ◽

Meiotic Arrest ◽

Male Hybrid ◽

Mule Duck

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Genetic basis of sterility in hybrid males from crosses of Glossina morsitans morsitans and Glossina morsitans centralis (Diptera: Glossinidae)

Canadian Journal of Zoology ◽

10.1139/z87-100 ◽

1987 ◽

Vol 65 (3) ◽

pp. 640-646 ◽

Cited By ~ 9

Author(s):

R. H. Gooding

Keyword(s):

X Chromosome ◽

Hybrid Sterility ◽

Glossina Morsitans Morsitans ◽

Marker Genes ◽

Genetic Constitution ◽

Glossina Morsitans ◽

Y Chromosomes ◽

Weak Evidence ◽

Glossina Morsitans Centralis ◽

Male Hybrid

Glossina morsitans morsitans Westwood and Glossina morsitans centralis Machado carrying from one to three marker genes on each chromosome were hybridized. F1 females were backcrossed and the resulting backcross males were tested for their ability to inseminate and to fertilize both G. m. morsitans and G. m. centralis; these abilities were then related to the genetic constitution of each male. Hybrid males having an X chromosome from one subspecies and a Y chromosome from the other were sterile, as were about half the males having X and Y chromosomes from the same subspecies. There is weak evidence for autosomal involvement in hybrid sterility but this involvement is not through genetical recombination between the loci Ao and Xo, nor does it depend upon the number of autosomes from the same taxon as the sex chromosomes. Hybrid males descending from G. m. morsitans females could not fertilize G. m. centralis although they could inseminate them. F1 hybrid females had lower than expected intrachromosomal recombination in the X chromosome and in linkage group II, and hybrid females tended to use autosomes of G. m. centralis origin more frequently than chromosomes from G. m. morsitans. Models for evolution of the maternally inherited sterility factor(s) suggest that G. m. centralis is ancestral to G. m. morsitans. Use of hybrid males descending from female G. m. morsitans for genetic control of G. m. centralis is proposed.

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