Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes

Sleep disturbances are common in attention deficit hyperactivity disorder (ADHD) and associated with poor outcomes. We tested whether, in children with ADHD, (1) polygenic liability for sleep phenotypes is over- or under-transmitted from parents, (2) this liability is linked to comorbid sleep disturbances, and (3) ADHD genetic risk is associated with comorbid sleep disturbances. We derived polygenic scores (PGS) for insomnia, chronotype, sleep duration, and ADHD, in 758 children (5–18 years old) diagnosed with ADHD and their parents. We conducted polygenic transmission disequilibrium tests for each sleep PGS in complete parent–offspring ADHD trios (N = 328) and an independent replication sample of ADHD trios (N = 844). Next, we tested whether insomnia, sleep duration, and ADHD PGS were associated with co-occurring sleep phenotypes (hypersomnia, insomnia, restless sleep, poor sleep quality, and nightmares) in children with ADHD. Children’s insomnia and chronotype PGS did not differ from mid-parent average PGS but long sleep duration PGS were significantly over-transmitted to children with ADHD. This was supported by a combined analysis using the replication sample. Insomnia, sleep duration, and ADHD PGS were not associated with comorbid sleep disturbances. There is weak evidence that children with ADHD over-inherit polygenic liability for longer sleep duration and do not differentially inherit polygenic liability for insomnia or chronotype. There was insufficient evidence that childhood sleep disturbances were driven by polygenic liability for ADHD or sleep traits, suggesting that sleep disturbances in ADHD may be aetiologically different to general population sleep phenotypes and do not index greater ADHD genetic risk burden.

No fingers, no SNARC? Spatial-Numerical Associations and temporal stability of finger counting

The Spatial-Numerical Association of Response Codes (SNARC) effect (i.e., faster left/right side responses to small/large magnitude numbers, respectively) is considered as strong evidence for the link between numbers and space. The studies have shown considerable variation in this effect. Among the factors determining individual differences in the SNARC effect is the hand an individual uses to start the finger counting sequence. Left-starters show a stronger and less variable SNARC effect than right-starters. This observation has been used as an argument for the embodied nature of the SNARC effect. For this to be the case, one must assume that the finger counting sequence (especially the starting hand) is stable over time. Subsequent studies challenged the view that the SNARC differs depending on the finger counting starting hand. At the same time, it has been pointed out that the temporal stability of finger counting starting hand should not be taken for granted. Thus, in this preregistered study, we aimed to replicate the difference in the SNARC between left- and right-starters and explore the relationship between the temporal stability of finger counting starting hand and the SNARC effect. We expected that higher stability should be associated with a stronger SNARC effect. Results of the preregistered analysis did not show the difference between left- and right-starters. However, further exploratory analysis provided weak evidence that this might be the case. Lastly, we found no evidence for the relationship between finger counting starting hand stability and the SNARC effect. Overall, these results challenge the view on the embodied nature of the SNARC effect.

A Feminist Rhetorical Analysis of Anti-feminist Poetry in English and Arabic

Language is the fundamental element of communication and understanding in society. It relates immediately to human thoughts and is embodied in written or spoken signs or signals. The field that scientifically studies language (its forms and structures) is called Linguistics. Among the linguistic studies of language is Rhetoric which studies the importance of speech or texts for the audience. Rhetoric is the art of persuasion; it comprises different arguments raised by the speaker/writer depending on social, religious, moral or even traditional evidence in order to prove that the raised arguments are real. In this way, the writer/speaker associates the language to similar or related realities in order to reach the purpose of her/his language. However, presenting arguments and evidence it not always accurate because there are arguments that rely on weak evidence. The purpose of argumentative techniques is still to persuade the audience about a personal view or a societal concept. From this perspective, the feminist linguists suggest that rhetoric is actually masculine; that is, rhetoric is anti-feminist. Therefore, linguists presented a great deal of evidence to prove this theory and bring the feminist ideology into rhetoric. This study aims at providing a feminist rhetorical analysis of the anti-feminist poetry to study the status of women in rhetoric and whether the arguments that demean women are true or not. For this purpose, the current study utilizes Fiorenza’s (1995) model of analysis; a feminist rhetorical tool to analyze anti-feminist poems written by male poets in English and Arabic in order to study the arguments as well as the evidence the poets present against women.

Why p-values are not measures of evidence

The recommendations by Muff and colleagues are an incoherent approach to statistical inferences, and should only be used if one wants to signal a misunderstanding of p-values. Coherent alternatives to quantify evidence exist, such as likelihoods and Bayes factors. Therefore, researchers should not follow the recommendation by Muff and colleagues to report p = 0.08 as ‘weak evidence’, p = 0.03 as ‘moderate evidence’, and p = 0.168 as ‘no evidence’.

Credibility contests: The contributions of experiential knowledge to radicalisation expertise

Radicalisation has become a highly influential idea in British policy making. It underpins and justifies Prevent, a core part of the UK's counter-terrorism strategy. Experts have theorised the radicalisation process, often beset by a weak evidence base and mired in fundamental contestation on definitions and explanatory factors. Experiential experts have been active contributors to these debates, presenting a challenge to the low-ranking role often given to experiential knowledge in evidence hierarchies and a contrast to policy areas in which it remains poorly valued. This paper draws on interviews with radicalisation experts to examine the dynamics of this pluralisation in practice. With a focus on credibility contests, it explains how experiential experts can claim authoritative knowledge and the challenges they face from those who prioritise theory-driven empirical data as the basis for contributions to knowledge. The paper draws out the implications for understandings of expertise of this newly conceptualised, evidence poor and highly applied topic area.

Child mortality in England during the first year of the COVID-19 pandemic

ObjectivesTo quantify the relative risk (RR) of childhood deaths across the whole of England during the first year of the COVID-19 pandemic, compared with a similar period of 2019.DesignThis work is based on data collected by the National Child Mortality Database (NCMD). Deaths from 1 April 2020 until 31 March 2021 (2020–2021) were compared with those from the same period of 2019–2020. RR and excess mortality were derived for deaths in 2020–2021 vs 2019–2020.SettingAll deaths reported to NCMD in England of children under 18 years of age, between April 2019 and March 2021.Participants6490 deaths of children, under the age of 18 years, reported to the NCMD over the study period.ResultsChildren had similar demographics in the 2 years. There were 356 (198–514) fewer deaths in 2020–2021 than in 2019–2020 (RR 0.90 (0.85 to 0.94), p<0.001). Deaths from infection (RR 0.49 (0.38 to 0.64)) and from other underlying medical conditions (RR 0.75 (0.68 to 0.82)) were lower in 2020–2021 than 2019–2020, and weak evidence (RR 0.50 (0.23 to 1.07), p=0.074) that this was also true of deaths from substance abuse.ConclusionsChildhood mortality in England during the first year of the SARS-CoV-2 pandemic was lower than expected, with over 300 fewer deaths than the preceding 12 months. The greatest reduction was in children less than 10 years old. It is important that we learn from this effect that potentially offers alternative ways to improve the outcome for the most vulnerable children in our society.

Use of the feline interdigital semiochemical (FIS) to redirect unwanted scratching behaviour in cats

PICO question Can the use of a synthetic feline interdigital semiochemical (FIS), with the provision of a scratching post, redirect unwanted scratching behaviour in cats better than provision of a scratching post alone? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Three studies were evaluated. One was a randomised blinded trial on a single group of subjects following a crossover repetition design (Cozzi et al., 2013), the second was an open, uncontrolled study (Beck et al., 2018), and the third was a randomised unblinded trial on a single group of subjects using a placebo (Zhang et al., 2019). Strength of evidence Weak Outcomes reported In two of the three studies where the FIS pheromone was applied to the scratching posts resulted in a statistically significant increase in the cats’ scratching behaviour compared to the control. The third study showed a result approaching statistical significance (p = 0.06). Conclusion Based on the assessed studies there is weak evidence that FIS used in conjunction with the provision of a scratching post is more successful in redirecting unwanted scratching behaviour than provision of a scratching post alone. However, further studies using larger and more representative cohorts are needed in order to confirm the accuracy of these results. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.

Effect of oromotor exercises on feeding in children with cerebral palsy: systematic review

Background Feeding problems are prevalent in children with cerebral palsy (CP). Oromotor exercises (OME) should be started as soon as possible to enhance chewing and drooling. Oromotor exercises consist of active exercises, passive exercises, and sensory stimulation. The purpose of this review is to evaluate the effectiveness of oromotor exercises on feeding, chewing, and drooling in children with CP. Body The American Academy for Cerebral Palsy and Developmental Medicine and Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology were used to conduct a systematic review. Four databases (PubMed, Cochrane Library, PEDro, and Google Scholar) were searched; this review includes seven articles, participants were 173 participants ranging in age from 18 months to 18 years. Articles were assessed according to their level of evidence and quality assessment was done by AACPDM, PEDro scale, and JBI scale. Due to the heterogeneity across included studies, descriptive analysis was performed on all of them. Primary outcomes were chewing and drooling. Results showed the effectiveness of OME in improving drooling, but with weak evidence while not effective in improving chewing. Conclusion High-quality studies are required to develop a firm judgment on the influence of oromotor exercises on feeding. The current level of evidence to support the effectiveness of oromotor exercises in children with CP is currently insufficient.

Ecological changes have driven biotic exchanges across the Indian Ocean

The Indian Ocean has a complex geological history that has drawn the attention of naturalists for almost a century now. Due to its tectonic history, many geological elements and processes have been evoked to explain the exchange of species between landmasses. Here, we revisited previous studies on twenty-three taxa to investigate trends across time since the Gondwana breakup. We investigated these datasets by applying a time-calibrated Bayesian framework to them and reconstructing their ancestral ranges. We conclude that ecological transformations have presented opportunities for the establishment of migrants. The role of donating and receiving migrants has shifted several times according to these transformations. Time-specific trends show weak evidence for the stepping-stones commonly suggested as physical routes between landmasses. However, before its collision with Asia, India may have served as an intermediary for such exchanges.