Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa

2001 ◽  
Vol 96 (6) ◽  
pp. 1758-1766 ◽  
Author(s):  
Brigitte Pignatelli ◽  
Brigitte Bancel ◽  
Martin Plummer ◽  
Shinya Toyokuni ◽  
Louis-Marc Patricot ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Human Gastric Mucosa ◽  
Helicobacter Pylori Eradication

scholarly journals Oxidative-stress-related proteome changes in Helicobacter pylori-infected human gastric mucosa

2004 ◽  
Vol 379 (2) ◽  
pp. 291-299 ◽  
Author(s):  
Hye Yeon BAEK ◽  
Joo Weon LIM ◽  
Hyeyoung KIM ◽  
Jung Mogg KIM ◽  
Joo Sung KIM ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Cell Damage ◽  
Blue Staining ◽  
Human Gastric Mucosa ◽  
Heat Shock Protein 60 ◽  
Gastric Diseases ◽  
Tryptic Fragment ◽  
H Pylori

Helicobacter pylori infection leads to gastroduodenal inflammation, peptic ulceration and gastric carcinoma. Proteomic analysis of the human gastric mucosa from the patients with erosive gastritis, peptic ulcer or gastric cancer, which were either infected or not with H. pylori, was used to determine the differentially expressed proteins by H. pylori in the human gastric mucosa in order to investigate the pathogenic mechanism of H. pylori-induced gastric diseases. Prior to the experiment, the expression of the main 18 proteins were identified in the gastric mucosa and used for a proteome map of the human gastric mucosa. Using two-dimensional electrophoresis of the protein isolated from the H. pylori-infected tissues, Coomassie Brilliant Blue staining and computerized analysis of the stained gel, the expression of eight proteins were altered in the H. pylori-infected tissues compared with the non-infected tissues. MS analysis (matrix-assisted laser desorption/ionization–time of flight MS) of the tryptic fragment and a data search allowed the the identification of the four increased proteins (78 kDa glucose-regulated protein precursor, endoplasmin precursor, aldehyde dehydrogenase 2 and l-lactate dehydrogenase B chain) and the four decreased proteins (intracellular chloride channel protein 1, glutathione S-transferase, heat-shock protein 60 and cytokeratin 8) caused by H. pylori infection in the gastric mucosa. These proteins are related to cell proliferation, carcinogenesis, cytoskeletal function and cellular defence mechanism. The common feature is that these proteins are related to oxidative-stress-mediated cell damage. In conclusion, the established gastric mucosal proteome map might be useful for detecting the disease-related protein changes. The H. pylori-induced alterations in protein expression demonstrate the involvement of oxidative stress in the pathogenesis of H. pylori-induced gastric diseases, including inflammation, ulceration and carcinogenesis.

The suppresive effect of a fermented milk containing lactobacilli on Helicobacter pylori in human gastric mucosa

2001 ◽  
Vol 120 (5) ◽  
pp. A590-A590 ◽  
Author(s):  
M PARK ◽  
J KIM ◽  
H JUNG ◽  
I SONG ◽  
J LEE
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Fermented Milk ◽  
Human Gastric Mucosa

Linked Color Imaging (LCI) Emphasizes the Color Changes in the Gastric Mucosa After Helicobacter pylori Eradication

2021 ◽  
Author(s):  
Hiroyuki Sakae ◽  
Hiromitsu Kanzaki ◽  
Takuya Satomi ◽  
Shotaro Okanoue ◽  
Yuka Obayashi ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Color Imaging ◽  
Helicobacter Pylori Eradication ◽  
Color Changes ◽  
Linked Color Imaging

scholarly journals Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum.

Gut ◽  
1990 ◽  
Vol 31 (11) ◽  
pp. 1230-1236 ◽  
Author(s):  
L L Thomsen ◽  
J B Gavin ◽  
C Tasman-Jones
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Human Gastric Mucosa

Su1179 Magnifying NBI Patterns of Gastric Mucosa After Helicobacter Pylori Eradication and its Potential Link to the Gastric Cancer Risk

2017 ◽  
Vol 85 (5) ◽  
pp. AB303
Author(s):  
Tomomitsu Tahara ◽  
Sayumi Tahara ◽  
Tetsuya Tsukamoto ◽  
Noriyuki Horiguchi ◽  
Tomohiko Kawamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Cancer Risk ◽  
Gastric Cancer Risk ◽  
Helicobacter Pylori Eradication ◽  
Potential Link
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