scholarly journals Purified sakacin A shows a dual mechanism of action against Listeria spp: proton motive force dissipation and cell wall breakdown

2012 ◽  
Vol 334 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Valentina Trinetta ◽  
Anna Morleo ◽  
Fabio Sessa ◽  
Stefania Iametti ◽  
Francesco Bonomi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mechanism Of Action ◽  
Proton Motive Force ◽  
Motive Force ◽  
Cell Wall Breakdown ◽  
Sakacin A ◽  
Dual Mechanism

scholarly journals Substrate Specificity of the AmpG Permease Required for Recycling of Cell Wall Anhydro-Muropeptides

2002 ◽  
Vol 184 (23) ◽  
pp. 6434-6436 ◽  
Author(s):  
Qiaomei Cheng ◽  
James T. Park
Keyword(s):  
Cell Wall ◽  
Substrate Specificity ◽  
Proton Motive Force ◽  
Single Component ◽  
Motive Force ◽  
Logarithmic Growth

ABSTRACT AmpG was originally identified as a gene required for induction of β-lactamase. Subsequently, we found AmpG to be a permease required for recycling of murein tripeptide and uptake of anhydro-muropeptides. We have now studied the specificity of the AmpG permease. The principal requirement is for the presence of the disaccharide, N-acetylglucosaminyl-β-1,4-anhydro-N-acetylmuramic acid (GlcNAc-anhMurNAc). These unique substrates for AmpG, which contain murein peptides linked to GlcNAc-anhMurNAc, are produced by turnover of the cell wall during logarithmic growth. AmpG permease is sensitive to carbonylcyanide m-chlorophenylhydrazone, demonstrating that AmpG permease is a single-component permease and that transport is dependent on the proton motive force.

scholarly journals Proton motive force may regulate cell wall-associated enzymes of Bacillus subtilis.

1993 ◽  
Vol 175 (17) ◽  
pp. 5690-5696 ◽  
Author(s):  
M A Kemper ◽  
M M Urrutia ◽  
T J Beveridge ◽  
A L Koch ◽  
R J Doyle
Keyword(s):  
Cell Wall ◽  
Bacillus Subtilis ◽  
Proton Motive Force ◽  
Motive Force

scholarly journals Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

2021 ◽  
Vol 22 (21) ◽  
pp. 11401
Author(s):  
Ying Luo ◽  
Yuzhu Song
Keyword(s):  
Antimicrobial Activity ◽  
Cell Wall ◽  
Antimicrobial Peptides ◽  
Mechanism Of Action ◽  
Comprehensive Review ◽  
Anti Inflammatory ◽  
Dual Mechanism ◽  
New Generation ◽  
Intracellular Action

Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs in vivo, and to fully understand AMPs to realize their therapeutic prospect.

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