Visual evoked potentials in normal subjects and patients with multiple sclerosis

2009 ◽  
Vol 62 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Mogens Kjaer
1997 ◽  
Vol 36 (04/05) ◽  
pp. 315-318 ◽  
Author(s):  
K. Momose ◽  
K. Komiya ◽  
A. Uchiyama

Abstract:The relationship between chromatically modulated stimuli and visual evoked potentials (VEPs) was considered. VEPs of normal subjects elicited by chromatically modulated stimuli were measured under several color adaptations, and their binary kernels were estimated. Up to the second-order, binary kernels obtained from VEPs were so characteristic that the VEP-chromatic modulation system showed second-order nonlinearity. First-order binary kernels depended on the color of the stimulus and adaptation, whereas second-order kernels showed almost no difference. This result indicates that the waveforms of first-order binary kernels reflect perceived color (hue). This supports the suggestion that kernels of VEPs include color responses, and could be used as a probe with which to examine the color visual system.


2014 ◽  
Vol 20 (10) ◽  
pp. 1342-1347 ◽  
Author(s):  
Giovanni Di Maggio ◽  
Roberto Santangelo ◽  
Simone Guerrieri ◽  
Mariangela Bianco ◽  
Laura Ferrari ◽  
...  

Objective: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). Methods: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0–4 conventional score. Results: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes ( p=0.11), 68% and 86% in eyes with previous ON ( p=0.12), and in 19% versus 40% in eyes without ON history ( p=0.007). Combining VEP and OCT increased sensitivity to 89% in ON and 44% in non-ON eyes. Considering all eyes, global retinal nerve fibre layer (RNFL) thickness and VEP score were significantly correlated between them (ρ=−0.63, p<0.001) and with EDSS (RNFL: ρ=0.40, p<0.001; VEP score: ρ=0.47, p<0.001). Disease duration correlated with VEP score (ρ=0.25, p=0.025) and RNFL thickness (ρ=−0.71, p<0.001). Conclusions: In eyes without ON, VEPs were more frequently abnormal than OCT, while the two techniques showed similar sensitivity in eyes previously affected by ON. The correlation of VEPs and OCT measures with disability prompts further exploration of the two techniques as potential markers of disease burden.


2011 ◽  
Vol 125 (6) ◽  
pp. 424-430 ◽  
Author(s):  
C. H. Hawkes ◽  
S. Chawda ◽  
S. Derakshani ◽  
N. Muhammed ◽  
E. Visentin ◽  
...  

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