Human choroidal endothelial cell growth factor signalling in age-related macular degeneration

2007 ◽  
Vol 85 ◽  
pp. 0-0
Author(s):  
EA STEWART ◽  
AC BROWING ◽  
WMK AMOAKU
1999 ◽  
Vol 19 (10) ◽  
pp. 2340-2347 ◽  
Author(s):  
Mihaela C. Ignatescu ◽  
Elisabeth Gharehbaghi-Schnell ◽  
Ali Hassan ◽  
Shahrzad Rezaie-Majd ◽  
Irina Korschineck ◽  
...  

1991 ◽  
Vol 11 (4) ◽  
pp. 2125-2132
Author(s):  
K Hagiwara ◽  
G Stenman ◽  
H Honda ◽  
P Sahlin ◽  
A Andersson ◽  
...  

Human platelet-derived endothelial cell growth factor (hPD-ECGF) is a novel angiogenic factor which stimulates endothelial cell growth in vitro and promotes angiogenesis in vivo. We report here the cloning and sequencing of the gene for hPD-ECGF and its flanking regions. This gene is composed of 10 exons dispersed over a 4.3-kb region. Its promoter lacks a TATA box and a CCAAT box, structures characteristic of eukaryotic promoters. Instead, six copies of potential Sp1-binding sites (GGGCGG or CCGCCC) were clustered just upstream of the transcription start sites. Southern blot analysis using genomic DNAs from several vertebrates suggested that the gene for PD-ECGF is conserved phylogenetically among vertebrates. The gene for hPD-ECGF was localized to chromosome 22 by analysis of a panel of human-rodent somatic cell hybrid lines.


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