Expression of IFN-γ before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase

Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. Materials and Methods: The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. Results: The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; p = 0.64) and 0.17 (95% CI: −1.50, 1.84; p = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; p = 0.43) and −0.39 (95% CI: −0.63, −0.15; p = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity.

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Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone

Oral Diseases ◽

10.1111/j.1601-0825.2005.01165.x ◽

2006 ◽

Vol 12 (2) ◽

pp. 112-116 ◽

Cited By ~ 68

Author(s):

NL Rhodus ◽

B Cheng ◽

W Bowles ◽

S Myers ◽

L Miller ◽

...

Keyword(s):

Lichen Planus ◽

Proinflammatory Cytokine ◽

Oral Lichen Planus ◽

Cytokine Levels ◽

Before And After ◽

Oral Lichen

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MiR-29b interacts with IFN-γ and induces DNA hypomethylation in CD4+ T cells of oral lichen planus

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2019.09.252 ◽

2020 ◽

Vol 147 ◽

pp. 1248-1254 ◽

Cited By ~ 1

Author(s):

Jing Zhang ◽

Guan-Ying Chen ◽

Fang Wang ◽

Gang Zhou

Keyword(s):

T Cells ◽

Lichen Planus ◽

Cd4 T Cells ◽

Oral Lichen Planus ◽

Dna Hypomethylation ◽

Ifn Γ ◽

Oral Lichen

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Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

Applied Sciences ◽

10.3390/app10227988 ◽

2020 ◽

Vol 10 (22) ◽

pp. 7988

Author(s):

Corinna Bruckmann ◽

Rudolf Seemann ◽

Klemens Rappersberger ◽

Xiaohui Rausch-Fan ◽

Hady Haririan ◽

...

Keyword(s):

Hyaluronic Acid ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Clinical Severity ◽

Clinical Parameters ◽

Whole Saliva ◽

Before And After ◽

Crossover Phase ◽

Lost To Follow Up ◽

Oral Lichen

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

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Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.219 ◽

2018 ◽

Vol 6 (5) ◽

pp. 879-884 ◽

Cited By ~ 3

Author(s):

Basma Mostafa ◽

Mai Zakaria

Keyword(s):

Lichen Planus ◽

Steroid Therapy ◽

Oral Lichen Planus ◽

Topical Steroid ◽

Topical Steroids ◽

Before And After ◽

Reported Data ◽

Oral Lichen ◽

Effective Adjunct ◽

Subsequent Improvement

AIM: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).METHODS: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Assessment of pain and sign scores was done before and after each treatment modality.RESULTS: The results revealed that the greatest significant percentage of change and subsequent improvement in pain and sign scores were recorded in the combined group.CONCLUSION: Reported data in this study using the combination of ozone and steroid therapy could provide a new promising safe and effective adjunct therapy for management of OLP.

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Effects of Hepatitis C Virus Elimination by Direct-Acting Antiviral Agents on the Occurrence of Oral Lichen Planus and Periodontal Pathogen Load: A Preliminary Report

International Journal of Dentistry ◽

10.1155/2021/8925879 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Yumiko Nagao ◽

Masahide Tsuji

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Periodontal Disease ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Periodontal Pathogen ◽

Periodontal Pathogens ◽

Periodontal Bacteria ◽

Before And After ◽

Oral Lichen

Objective. The association between hepatitis C virus (HCV) and oral lichen planus (OLP) is well known, but the association with periodontal disease has been reported less often. The purpose of this study was to investigate the effects of periodontal bacteria and OLP lesions before and after HCV elimination. Subjects and Methods. The subjects were four OLP patients (mean age 72.5 years) with HCV infection. Six types of periodontal bacteria (Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum) were quantified in saliva, and changes in OLP were examined before and after elimination of HCV by antiviral therapy. Biochemical blood tests also were performed. Results. The total number of periodontal bacteria, the numbers of P. gingivalis, T. forsythia, T. denticola, and F. nucleatum, and the risk of presenting with the red-complex bacteria (P. gingivalis, T. forsythia, and T.denticola), leading to periodontal disease progression, decreased after HCV elimination. OLP disappeared in three of the four patients and decreased in the other after sustained virological responses (SVRs). Conclusion. HCV elimination not only improved OLP lesions but also reduced the number of periodontal pathogens and the amount of red-complex periodontal pathogens.

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