scholarly journals Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

2020 ◽  
Vol 10 (22) ◽  
pp. 7988
Author(s):  
Corinna Bruckmann ◽  
Rudolf Seemann ◽  
Klemens Rappersberger ◽  
Xiaohui Rausch-Fan ◽  
Hady Haririan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Severity ◽  
Clinical Parameters ◽  
Whole Saliva ◽  
Before And After ◽  
Crossover Phase ◽  
Lost To Follow Up ◽  
Oral Lichen

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone

Oral Diseases ◽  
2006 ◽  
Vol 12 (2) ◽  
pp. 112-116 ◽  
Author(s):  
NL Rhodus ◽  
B Cheng ◽  
W Bowles ◽  
S Myers ◽  
L Miller ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Proinflammatory Cytokine ◽  
Oral Lichen Planus ◽  
Cytokine Levels ◽  
Before And After ◽  
Oral Lichen

scholarly journals Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus

2018 ◽  
Vol 6 (5) ◽  
pp. 879-884 ◽  
Author(s):  
Basma Mostafa ◽  
Mai Zakaria
Keyword(s):  
Lichen Planus ◽  
Steroid Therapy ◽  
Oral Lichen Planus ◽  
Topical Steroid ◽  
Topical Steroids ◽  
Before And After ◽  
Reported Data ◽  
Oral Lichen ◽  
Effective Adjunct ◽  
Subsequent Improvement

AIM: The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).METHODS: Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Assessment of pain and sign scores was done before and after each treatment modality.RESULTS: The results revealed that the greatest significant percentage of change and subsequent improvement in pain and sign scores were recorded in the combined group.CONCLUSION: Reported data in this study using the combination of ozone and steroid therapy could provide a new promising safe and effective adjunct therapy for management of OLP.

scholarly journals Dysbiosis of saliva microbiome in patients with oral lichen planus

2020 ◽  
Author(s):  
FeiYan Yu ◽  
QianQian Wang ◽  
Miao Li ◽  
Ya-Hsin Cheng ◽  
Yi-Shing Lisa Cheng ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Relative Abundance ◽  
Oral Lichen Planus ◽  
Disease Process ◽  
Composition Analysis ◽  
Oral Microbiota ◽  
Linear Discriminant ◽  
Α Diversity ◽  
Whole Saliva ◽  
Oral Lichen

Abstract Background : Oral microbiota is not only important for maintaining oral health but also plays a role in oral diseases. However, studies regarding microbiome changes in oral lichen planus(OLP)are very limited. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive/ulcerative lesions. Methods : Whole saliva samples were collected from 20 patients with OLP (10 each for erosive (E) and non-erosive (NE) groups), 10 patients with RAU (U group), and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing. Results were assessed with alpha- and beta-diversity, linear discriminant analysis (LDA) effect size, and the data was analyzed by Spearman’s rank correlation,Wilcoxon and Kruskal test. Results: We obtained 4949 operational taxonomic units from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera Streptococcus and Sphingomonas in saliva from RAU patients when compared to the other three groups. Relative abundance of Lautropia and Gemella were higher in E group,whereas relative abundance of Haemophilus and Neisseria were higher in NE group when compared to C group. Abiotrophia and Oribacterium were higher in OLP (combining E and NE groups), while Eikenella and Aggregatibacter were lower when compared to C group. There was statistically significance in α-diversity between E and RAU groups( p <0.05). Significant differences in β-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. Conclusion： We found that salivary microbiome in OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.

scholarly journals Dysbiosis of saliva microbiome in patients with oral lichen planus

2019 ◽  
Author(s):  
FeiYan Yu ◽  
QianQian Wang ◽  
Miao Li ◽  
Ya-Hsin Cheng ◽  
Yi-Shing Lisa Cheng ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Relative Abundance ◽  
Oral Lichen Planus ◽  
Disease Process ◽  
Composition Analysis ◽  
Oral Microbiota ◽  
Linear Discriminant ◽  
Α Diversity ◽  
Whole Saliva ◽  
Oral Lichen

Abstract Background : Oral microbiota is not only important for maintaining oral health but also plays a role in oral diseases. However, studies regarding microbiome changes in oral lichen planus(OLP)are very limited. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive/ulcerative lesions. Methods : Whole saliva samples were collected from 20 patients with OLP (10 each for erosive (E) and non-erosive (NE) groups), 10 patients with RAU (U group), and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing. Results were assessed with alpha- and beta-diversity, linear discriminant analysis (LDA) effect size, and the data was analyzed by Spearman’s rank correlation,Wilcoxon and Kruskal test. Results: We obtained 4949 operational taxonomic units from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera Streptococcus and Sphingomonas in saliva from RAU patients when compared to the other three groups. Relative abundance of Lautropia and Gemella were higher in E group,whereas relative abundance of Haemophilus and Neisseria were higher in NE group when compared to C group. Abiotrophia and Oribacterium were higher in OLP (combining E and NE groups), while Eikenella and Aggregatibacter were lower when compared to C group. There was statistically significance in α-diversity between E and RAU groups( p <0.05). Significant differences in β-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. Conclusion： We found that salivary microbiome in OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.

scholarly journals Effects of Hepatitis C Virus Elimination by Direct-Acting Antiviral Agents on the Occurrence of Oral Lichen Planus and Periodontal Pathogen Load: A Preliminary Report

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yumiko Nagao ◽  
Masahide Tsuji
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Periodontal Disease ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Periodontal Pathogen ◽  
Periodontal Pathogens ◽  
Periodontal Bacteria ◽  
Before And After ◽  
Oral Lichen

Objective. The association between hepatitis C virus (HCV) and oral lichen planus (OLP) is well known, but the association with periodontal disease has been reported less often. The purpose of this study was to investigate the effects of periodontal bacteria and OLP lesions before and after HCV elimination. Subjects and Methods. The subjects were four OLP patients (mean age 72.5 years) with HCV infection. Six types of periodontal bacteria (Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum) were quantified in saliva, and changes in OLP were examined before and after elimination of HCV by antiviral therapy. Biochemical blood tests also were performed. Results. The total number of periodontal bacteria, the numbers of P. gingivalis, T. forsythia, T. denticola, and F. nucleatum, and the risk of presenting with the red-complex bacteria (P. gingivalis, T. forsythia, and T.denticola), leading to periodontal disease progression, decreased after HCV elimination. OLP disappeared in three of the four patients and decreased in the other after sustained virological responses (SVRs). Conclusion. HCV elimination not only improved OLP lesions but also reduced the number of periodontal pathogens and the amount of red-complex periodontal pathogens.

The feasibility of monitoring NF-κB associated cytokines: TNF-α, IL-1α, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus

2005 ◽  
Vol 44 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Sandra Myers ◽  
Lindsay Miller ◽  
Vu Ho ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Α ◽  
Whole Saliva ◽  
Oral Lichen

scholarly journals p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus

2013 ◽  
Vol 14 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Iraj Mirzaii-Dizgah ◽  
Farzaneh Agha-Hosseini
Keyword(s):  
Clinical Significance ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Control Group ◽  
Whole Saliva ◽  
The Mean ◽  
Unstimulated Whole Saliva ◽  
Oral Lichen ◽  
Mean Concentration

ABSTRACT Aim Unstimulated whole salivary p53 was assessed in patients suffering from erosive and plaque-like form of oral lichen planus (OLP). Materials and methods Eighteen patients with erosive form, 17 patients suffering from plaque-like form and 38 noninvolvement subjects were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA. Results The mean concentration of salivary p53 was significantly higher in patients with plaque-like form compared to both patients with erosive form and the control group. Conclusion We conclude that plaque like form of OLP is important in view of the potential for malignancy and is not safety form. Clinical significance It seems that all forms of OLP must be considered accurately, should be followed up with biannual examinations, and if possible, assessment of salivary p53 every year. How to cite this article Agha-Hosseini F, Mirzaii-Dizgah I. p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus. J Contemp Dent Pract 2013;14(1):1-3.

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