EGF/TGFβ1 co-stimulation of oral squamous cell carcinoma cells causes an epithelial-mesenchymal transition cell phenotype expressing laminin 332

2010 ◽  
Vol 40 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Petra Richter ◽  
Claudia Umbreit ◽  
Marcus Franz ◽  
Angela Berndt ◽  
Susanne Grimm ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Cell Phenotype ◽  
Mesenchymal Transition ◽  
Laminin 332 ◽  
Stimulation Of

scholarly journals Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Su-Bin Yu ◽  
Hae-Mi Kang ◽  
Dan-Bi Park ◽  
Bong-Soo Park ◽  
In-Ryoung Kim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Underlying Mechanism ◽  
Cell Phenotype ◽  
Root Bark ◽  
Dependent Manner ◽  
Mesenchymal Transition

Cudraxanthone D (CD), derived from the root bark of Cudrania tricuspidata, is a natural xanthone compound. However, the biological activity of CD in terms of human metabolism has been barely reported to date. Autophagy is known as a self-degradation process related to cancer cell viability and metastasis. Herein, we investigated the effects of CD on human oral squamous cell carcinoma (OSCC) metastatic related cell phenotype. We confirmed that CD effectively decreased proliferation and viability in a time- and dose-dependent manner in human OSCC cells. In addition, OSCC cell migration, invasion, and EMT were inhibited by CD. To further determine the underlying mechanism of CD’s inhibition of cell metastatic potential, we established the relationship between EMT and autophagy in OSCC cells. Thus, our findings indicated that CD inhibited the potential metastatic abilities of OSCC cells by attenuating autophagy.

scholarly journals ET-1 Promotes Epithelial–Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells via the microRNA-489-3p /TWIST Axis

2021 ◽  
Vol Volume 14 ◽  
pp. 5005-5018
Author(s):  
Huey-En Tzeng ◽  
Chih-Hsin Tang ◽  
Chun-Hao Tsai ◽  
Chih-Hui Chiu ◽  
Min-Huan Wu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mesenchymal Transition
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