Expression of MMPs and TIMP-1 in smoker and nonsmoker chronic periodontitis patients before and after periodontal treatment

2012 ◽  
Vol 47 (4) ◽  
pp. 532-542 ◽  
Author(s):  
E. Mouzakiti ◽  
E. Pepelassi ◽  
G. Fanourakis ◽  
C. Markopoulou ◽  
S. Tseleni-Balafouta ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Before And After

scholarly journals EVALUATION OF SALIVARY HEPATOCYTE GROWTH FACTOR LEVELS IN CHRONIC PERIODONTITIS PATIENTS BEFORE AND AFTER NON-SURGICAL PERIODONTAL TREATMENT

2020 ◽  
pp. 8-10
Author(s):  
Madhavi T ◽  
Mathew John ◽  
Bindu Rachel Thomas ◽  
Sabari Chandramohan ◽  
Aswathy S ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Periodontal Tissues ◽  
Whole Saliva ◽  
Before And After ◽  
Unstimulated Whole Saliva ◽  
Relationship Of ◽  
Hepatocyte Growth

Hepatocyte Growth Factor (HGF) or Scatter Factor (SF) is a growth factor which restrains the reconstruction of profound periodontal tissues. The study estimated the salivary HGF levels in unstimulated whole saliva in chronic periodontitis patients prior to treatment and also at 2nd and 6th week after non-surgical periodontal treatment and also aimed to determine the relationship of salivary HGF levels with the clinical periodontal parameters. This was a prospective-analytical study which included 45 subjects with chronic periodontitis. The highest mean concentration of HGF was obtained at the baseline and the lowest mean HGF concentration was obtained at the 6th week. There was significant decrease in the salivary HGF levels among the patients subsequent to scaling and root planing. Moreover the salivary HGF levels indicated a positive correlation with the clinical parameters at the sixth week. The above results propose that salivary HGF levels could be utilized as a biomarker for checking the response to periodontal treatment in chronic periodontitis patients.

scholarly journals Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy

2021 ◽  
Author(s):  
Shahrzad Shahbeik ◽  
Ferial Taleghani ◽  
Mandana Sattari ◽  
Mahyar Mahvash Mohammadi ◽  
Mohammadreza Moravej
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Pearson Correlation ◽  
Treatment Phase ◽  
Periodontal Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Mean Values ◽  
Before And After

The progression of periodontitis depends on interactions between the periodontal pathogens and the host immune cytokines, including interleukin (IL)-1β and IL-18. Production of IL-1β is regulated by NOD-like receptors family pyrin domain containing 3 (NLRP3). This study aimed to evaluate the effect of periodontal treatment on the concentrations of IL-18 and NLRP3 in patients with chronic periodontitis. In this experimental study, 18 patients with chronic periodontitis and a mean age of 46.2±8.95 years, were included. The gingival crevicular fluid (GCF) was collected at the beginning of the study, 4 weeks after non-surgical (phase I), and 4 weeks after surgical periodontal treatment. The levels of NLRP3 and IL-18 were measured; using an enzyme-linked immunosorbent assay. Pearson correlation test was used to analyze the concentration of NLRP3 and IL-18 before and after the treatments with CAL and PD. There was a significant association between the level of NLRP3 and the mean values of PD and CAL before treatment. After each treatment phase, a significant decrease was observed in the NLRP3 level. There was no significant relationship between IL-18 and clinical parameters before and after periodontal treatments. Given the possible association between the level of NLRP3 and clinical parameters, we suggest it as a possible indicator of inflammation in chronic periodontitis and an index for evaluating the treatment outcome.

scholarly journals Implant Treatment with 12-Year Follow-Up in a Patient with Severe Chronic Periodontitis: A Case Report and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Keisuke Seki ◽  
Yoshiyuki Hagiwara
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Case Reports ◽  
English Literature ◽  
Supportive Therapy ◽  
Periodontal Treatment ◽  
Periodontal Tissues ◽  
Severe Periodontitis ◽  
And Control ◽  
Implant Treatment

Tooth loss among adults is associated with progressive periodontitis. Implant prosthetic treatment has long been utilized in periodontal patients. Even when the implants are applied, ongoing management of periodontal disease and control of inflammation is necessary to maintain a healthy oral cavity. Lack of appropriate periodontal treatment can result in recurrence of periodontal disease during a maintenance period; loss of the supportive capacity of the periodontal tissues will increase the susceptibility of residual teeth to traumatic force. For this reason, it is worthwhile to improve oral function by applying implants as a fixed device. Here, we report that implant treatment in a patient with generalized severe chronic periodontitis helped maintain the periodontal and peri-implant tissue for a long term. We propose that initial periodontal treatment and ongoing supportive therapy can help maintain implants in patients with severe periodontitis. In addition, we reviewed case reports in the English literature so far.

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