Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease

2004 ◽  
Vol 37 (4) ◽  
pp. 252-256 ◽  
Author(s):  
Isaac Túnez ◽  
Pedro Montilla ◽  
M. del Carmen Muñoz ◽  
Montserrat Feijóo ◽  
Manuel Salcedo
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Protective Effect ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Protective effect ofCalendula officinalisLinn. flowers against 3-nitropropionic acid induced experimental Huntington’s disease in rats

2013 ◽  
Vol 36 (4) ◽  
pp. 466-473 ◽  
Author(s):  
B. D. Shivasharan ◽  
Pandian Nagakannan ◽  
Boreddy Shivanandappa Thippeswamy ◽  
Veeresh Prabakar Veerapur ◽  
Punit Bansal ◽  
...  
Keyword(s):  
Protective Effect ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals Increased Vulnerability to 3-Nitropropionic Acid in an Animal Model of Huntington's Disease

2002 ◽  
Vol 71 (6) ◽  
pp. 2642-2644 ◽  
Author(s):  
Mikhail B. Bogdanov ◽  
Robert J. Ferrante ◽  
Stefan Kuemmerle ◽  
Peter Klivenyi ◽  
M. Flint Beal
Keyword(s):  
Animal Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals Protective Activity of Esculetin Against 3-Nitropropionic Acid Induced Neurotoxicity Via Scavenging Reactive Oxygen Species in Male Wistar Rats

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Arpita Karandikar ◽  
Sumathi Thangarajan
Keyword(s):  
Oxidative Stress ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Neuroprotective Activity ◽  
Protein Carbonyls ◽  
Rat Striatum ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Huntington’s disease (HD) is a devastating neurodegenerative disorder with no cure till date. Many genetic or chemically induced models have been developed in rodents to study the disease. 3-Nitropropionic (3-NP) acid is a well-known neurotoxin to induce Huntington’s disease (HD) in rodents. It replicates the pathology of HD by causing oxidative stress. Esculetin is a natural compound, a coumarin, known to have neuroprotective effect in a mouse model of Parkinson’s disease. In the present study, the neuroprotective effect of esculetin on 3-NP induced oxidative stress in rat striatum was determined by behavioral and biochemical parameters. Rats were induced with 3-NP (10mg/kg) intraperitoneally for 14 days and rats induced with 3-NP were treated with esculetin (25mg/kg and 50mg/kg) for 14 days. Esculetin attenuated the behaviour of rats in morris water maze, open field, forced swim, narrow beam walk and grip strength test. Biochemical effect of esculetin was also studied on oxidative stress markers, SDH and acetylcholinesterase. Esculetin treatment alleviated the increased values of acetylcholinesterase, protein carbonyls and lipid peroxidation. On treatment with esculetin, we observed that the levels of SOD, GSH, catalase, glutathione peroxidase, SDH were increased. The present study shows that the antioxidant activity of esculetin may be responsible for its neuroprotective activity against 3- nitropropionic acid induced neurotoxicity in rats

scholarly journals Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

2015 ◽  
Vol 36 (3) ◽  
pp. 311-322 ◽  
Author(s):  
Yan Gao ◽  
Shi-feng Chu ◽  
Jian-ping Li ◽  
Zhao Zhang ◽  
Jia-qing Yan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Rat Model ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid
Sign in / Sign up

Export Citation Format

Share Document