In vitro characterization of poly(ethylene) glycol calcium citrate microspheres as a delivery system for the study of reparative dentinogenesis

Abstract Electrospinning (ES) is a versatile and diverse technique to fabricate nano and micro fibers that could be utilized as drug delivery systems. The aim of this research was the fabrication and characterization of drug loaded nanofibrous scaffold produced by single-needle ES using poly(Ɛ-caprolactone) (PCL) and poly(ethylene glycol-400) (PEG) and to investigate the potential of this material as a drug delivery system. A model drug, Ibuprofen (IBU), was used. Ibuprofen is a medicine that is a non-steroidal, anti-inflammatory drug (NSAID). Two concentrations of IBU, 5 wt% and 7 wt%, were incorporated for the ES of PCL and PCL/PEG nanofibers. Characterization of nanofibers was done by using Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC), Thermogravimetric Analysis (TGA), and Water Contact Angle Measurements. The impact of IBU on nanofibers’ properties such as morphology, diameters, hydrophilicity, and tensile strength was investigated. Finally, the drug release kinetics of IBU from nanofibers was analyzed and their percentage release efficiency of IBU (RE%) was determined by UV-vis spectroscopy during 24 h.

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Poly(ethylene glycol)-Block-Poly(2-methyl-2-benzoxycarbonyl-propylene Carbonate) Micelles for Rapamycin Delivery: In Vitro Characterization and Biodistribution

Journal of Pharmaceutical Sciences ◽

10.1002/jps.22467 ◽

2011 ◽

Vol 100 (6) ◽

pp. 2418-2429 ◽

Cited By ~ 24

Author(s):

Wenli Lu ◽

Feng Li ◽

Ram I. Mahato

Keyword(s):

Ethylene Glycol ◽

Propylene Carbonate ◽

Poly Ethylene Glycol ◽

In Vitro Characterization ◽

Poly Ethylene

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Physicochemical and Biological Characterization of Polyethylenimine-graft-Poly(ethylene glycol) Block Copolymers as a Delivery System for Oligonucleotides and Ribozymes

Bioconjugate Chemistry ◽

10.1021/bc034160m ◽

2004 ◽

Vol 15 (4) ◽

pp. 677-684 ◽

Cited By ~ 58

Author(s):

Carola Brus ◽

Holger Petersen ◽

Achim Aigner ◽

Frank Czubayko ◽

Thomas Kissel

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Delivery System ◽

Biological Characterization ◽

Poly Ethylene Glycol ◽

Poly Ethylene

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In vitro and in vivo investigation of chitosan–polylysine polymeric nanoparticles for ovalbumin and CpG co-delivery

RSC Advances ◽

10.1039/c7ra06450k ◽

2017 ◽

Vol 7 (63) ◽

pp. 39962-39969 ◽

Cited By ~ 5

Author(s):

Yunfei Han ◽

Qian Duan ◽

Yanhui Li ◽

Jian Tian

Keyword(s):

Ethylene Glycol ◽

Delivery System ◽

Polymeric Nanoparticles ◽

Poly Ethylene Glycol ◽

Glycol Chitosan ◽

Vaccine Delivery System ◽

Electrostatic Binding ◽

Poly Ethylene

A simple and powerful vaccine delivery system was developed by electrostatic binding of chitosan-based polycation methoxy poly(ethylene glycol)–chitosan–poly(l-lysine) (mPEG–CS–PLL) with ovalbumin (OVA) and cytosine–phosphate–guanine (CpG).

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