In vitro and in vivo investigation of chitosan–polylysine polymeric nanoparticles for ovalbumin and CpG co-delivery

A simple and powerful vaccine delivery system was developed by electrostatic binding of chitosan-based polycation methoxy poly(ethylene glycol)–chitosan–poly(l-lysine) (mPEG–CS–PLL) with ovalbumin (OVA) and cytosine–phosphate–guanine (CpG).

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Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

Toxicologic Pathology ◽

10.1177/0192623318810199 ◽

2018 ◽

Vol 47 (3) ◽

pp. 426-432 ◽

Cited By ~ 3

Author(s):

Sivan Yogev ◽

Ayelet Shabtay-Orbach ◽

Abraham Nyska ◽

Boaz Mizrahi

Keyword(s):

Block Copolymer ◽

Ethylene Glycol ◽

Medical Devices ◽

Poly Lactic Acid ◽

Poly Ethylene Glycol ◽

Thermoresponsive Polymers ◽

Wide Range ◽

Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

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In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽

10.1016/s0142-9612(03)00495-2 ◽

2004 ◽

Vol 25 (2) ◽

pp. 247-258 ◽

Cited By ~ 59

Author(s):

A.A. Deschamps ◽

A.A. van Apeldoorn ◽

H. Hayen ◽

J.D. de Bruijn ◽

U. Karst ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

In Vitro Degradation ◽

Butylene Terephthalate ◽

Poly Ethylene ◽

Ether Ester

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A pH and Redox Dual Responsive 4-Arm Poly(ethylene glycol)-block-poly(disulfide histamine) Copolymer for Non-Viral Gene Transfection in Vitro and in Vivo

International Journal of Molecular Sciences ◽

10.3390/ijms15059067 ◽

2014 ◽

Vol 15 (5) ◽

pp. 9067-9081 ◽

Cited By ~ 13

Author(s):

Kangkang An ◽

Peng Zhao ◽

Chao Lin ◽

Hongwei Liu

Keyword(s):

Ethylene Glycol ◽

Gene Transfection ◽

Viral Gene ◽

Poly Ethylene Glycol ◽

Dual Responsive ◽

Poly Ethylene

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In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2007.03.045 ◽

2007 ◽

Vol 341 (1-2) ◽

pp. 50-57 ◽

Cited By ~ 9

Author(s):

Hoo-Kyun Choi ◽

Myung-Kwan Chun ◽

Se Hee Lee ◽

Mee Hee Jang ◽

Hee Doo Kim ◽

...

Keyword(s):

Ethylene Glycol ◽

In Vivo Study ◽

Poly Ethylene Glycol ◽

Duration Of Action ◽

Poly Ethylene

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Asialoglycoprotein receptor targeted gene delivery using galactosylated polyethylenimine-graft-poly(ethylene glycol): In vitro and in vivo studies

Journal of Controlled Release ◽

10.1016/j.jconrel.2005.09.001 ◽

2005 ◽

Vol 108 (2-3) ◽

pp. 557-567 ◽

Cited By ~ 45

Author(s):

Eun-Mi Kim ◽

Hwan-Jeong Jeong ◽

In-Kyu Park ◽

Chong-Su Cho ◽

Hyung-Bae Moon ◽

...

Keyword(s):

Gene Delivery ◽

Ethylene Glycol ◽

Asialoglycoprotein Receptor ◽

In Vivo Studies ◽

Poly Ethylene Glycol ◽

Targeted Gene Delivery ◽

Poly Ethylene

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Stabilization of L-Asparaginase Modified with Comb-Shaped Poly(ethylene glycol) Derivatives, in vivo and in vitro

Bioconjugate Chemistry ◽

10.1021/bc00028a001 ◽

1994 ◽

Vol 5 (4) ◽

pp. 283-286 ◽

Cited By ~ 23

Author(s):

Yoh Kodera ◽

Taichi Sekine ◽

Tohru Yasukohchi ◽

Yoshihiro Kiriu ◽

Misao Hiroto ◽

...

Keyword(s):

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Ethylene Glycol Derivatives

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In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(ethylene-glycol)-modified PLA (BAB type) triblock copolymer

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2009.04.017 ◽

2009 ◽

Vol 72 (2) ◽

pp. 303-311 ◽

Cited By ~ 46

Author(s):

Xiaoqian Shan ◽

Changsheng Liu ◽

Yuan Yuan ◽

Feng Xu ◽

Xinyi Tao ◽

...

Keyword(s):

Ethylene Glycol ◽

Triblock Copolymer ◽

Poly Ethylene Glycol ◽

In Vivo Biodistribution ◽

Poly Ethylene ◽

Macrophage Uptake

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A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽

10.2217/nnm-2018-0378 ◽

2019 ◽

Vol 14 (15) ◽

pp. 2011-2025 ◽

Cited By ~ 9

Author(s):

Zhen Li ◽

Jialong Fan ◽

Chunyi Tong ◽

Hongyan Zhou ◽

Wenmiao Wang ◽

...

Keyword(s):

Drug Delivery ◽

Quantum Dots ◽

Folic Acid ◽

Ethylene Glycol ◽

Drug Delivery System ◽

Delivery System ◽

Graphene Quantum Dots ◽

Poly Ethylene Glycol ◽

Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

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