Background Melasma, also known as chloasma or mask of pregnancy, is a
common, acquired, hyperpigmentary disorder usually affecting females.
Tranexamic acid (TA), a derivative of amino acid lysine has shown
promising results over the past few years when used along with other
therapies as well as when used as a stand-alone therapy. Aim of the Work
In this study, we aimed to evaluate and compare the effectiveness of
topically applied tranexamic acid after microneedling versus topically
applied hydroquinone 4% alone in patients with melasma. Patients and
Methods Fifty selected patients were divided randomly according to the
random number allocation method into two groups (25 patients each) of A
(topical 4% hydroquinone, nightly application) and B (microneedling +
topical 4% TA, every other week). Results After Eight weeks of
treatment, the mean modified MASI score of the HQ treated side changed
from 6.604±4.02 to 3.032±1.19 with a mean decrease percentage of
54.8%±19.4%. This reduction in modified MASI score was found to be
statistically significant, (p<0.001). MASI score of group B
(TA + microneedling) changed from 6.348±3.84 to 3.712±1.19 with mean
decrease percentage of 57.4%±23.4% which was also statistically
significant, (p<0.001). Conclusion We demonstrated safety and
efficacy of both used modalities and with minimal side effects. Topical
HQ application achieved minimal non significant higher satisfactory
results among raters and subjects
Microneedling-Assisted Topical Tranexamic Acid Solution versus 4% Hydroquinone for Treating Melasma: A Split-Face randomized study