Interleukin-6 in cerebrospinal fluid of patients with central nervous system infections

1995 ◽  
Vol 84 (8) ◽  
pp. 879-883 ◽  
Author(s):  
Y Matsuzono ◽  
M Narita ◽  
Y Akutsu ◽  
T Togashi
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Interleukin 6 ◽  
Central Nervous System Infections

Interleukin 6 in Cerebrospinal Fluid of Patients with Meningitis is not a Useful Diagnostic Marker in the Differential Diagnosis of Meningitis

1997 ◽  
Vol 34 (2) ◽  
pp. 165-169 ◽  
Author(s):  
L F López-Cortés ◽  
M Cruz-Ruiz ◽  
J Gómez-Mateos ◽  
D Jiménez-Hernández ◽  
P Viciana-Fernández ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Monoclonal Antibody ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Differential Diagnosis ◽  
Interleukin 6 ◽  
Diagnostic Marker ◽  
Neurological Diseases ◽  
Central Nervous System Infections ◽  
Pyogenic Meningitis

We assayed interleukin 6 (IL-6) concentrations in cerebrospinal fluid (CSF) from patients affected by meningitis of different aetiologies, and verified whether IL-6 can be used as a diagnostic marker in the differential diagnosis of meningitis. We used a monoclonal antibody enzyme immunoassay to test 98 CSF samples classified as pyogenic (15), viral (15), self-resolving aseptic meningitis (20), other infectious meningitis (9), neoplastic (4) and normal CSF from patients with (20) and without (15) non-infectious neurological diseases. CSF IL-6 concentrations were increased in pyogenic meningitis (100%) and in more than 50% of viral and other subarachnoid space infections, and rarely in patients without central nervous system infections. Though patients affected by pyogenic meningitis showed the highest levels of CSF IL-6, only a cut-off point ≥10000 pg/mL was able to discriminate pyogenic meningitis from those of other aetiologies with a specificity ≥94% and a positive predictive value of ≥0·75 but the sensitivity was ≤60%. Therefore, CSF IL-6 concentration is not a good diagnostic marker in the differential diagnosis of meningitis.

Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections

2019 ◽  
Vol 220 (1) ◽  
pp. 127-138 ◽  
Author(s):  
Kurt-Wolfram Sühs ◽  
Natalia Novoselova ◽  
Maike Kuhn ◽  
Lena Seegers ◽  
Volkhard Kaever ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Infections ◽  
Fluid Biomarker

scholarly journals Cerebrospinal Fluid Interleukin-6 in Central Nervous System Inflammatory Diseases

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72399 ◽  
Author(s):  
Alexandre Wullschleger ◽  
Viktoria Kapina ◽  
Nicolas Molnarfi ◽  
Delphine S. Courvoisier ◽  
Jörg D. Seebach ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Interleukin 6 ◽  
Inflammatory Diseases

Cerebrospinal fluid ?2-microglobulin in neonates with central nervous system infections

1995 ◽  
Vol 154 (4) ◽  
pp. 309-313 ◽  
Author(s):  
A. Garc�a-Alix ◽  
A. Mart�n-Ancel ◽  
Mar�a Teresa Ramos ◽  
Sof�a Salas ◽  
Adelina Pellicer ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Infections

Neopterin, biopterin, and nitric oxide concentrations in the cerebrospinal fluid of children with central nervous system infections

2003 ◽  
Vol 25 (3) ◽  
pp. 200-202 ◽  
Author(s):  
Kohji Azumagawa ◽  
Shuhei Suzuki ◽  
Takuya Tanabe ◽  
Eiji Wakamiya ◽  
Naohisa Kawamura ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Infections
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