Elevated nocturnal blood pressure and heart rate in adolescent chronic fatigue syndrome

1. Chronic low blood pressure has been associated with fatigue and low mood. However, in the chronic fatigue syndrome (CFS) the blood pressure (BP) and heart rate profile and their variabilities have not been characterized as yet. 2. We performed office and 24 h ambulatory BP recordings in 38 subjects (age, 34.8 ± 8.0 years) who fulfilled the Holmes criteria for CFS and in 38 healthy control subjects (age 35.6 ± 10.5 years), as well as short-term beat-to-beat BP and RR-interval recordings for 10 min in supine and standing position, and calculated spectral indices. 3. In CFS office (123 ± 19/70 ± 12 mmHg) as well as 24-h, day- and night-time blood pressure values (116 ± 11.1/71 ± 11.1, 121 ± 9.2/77 ± 8.0 and 110 ± 10.5/65 ± 9.2 mmHg respectively) were within reference limits. 4. Heart rate was consistently higher (P < 0.01) in CFS patients, based on both office (77 ± 12 compared with 68 ± 12 beats min−-1) and 24 h ambulatory recordings (77 ± 12 compared with 67 ± 15 beats min−-1). 5. In supine position, spectral indices of BP variability (total, low-frequency and high-frequency variances) were all significantly (P < 0.01) lower in CFS. In standing position the differences disappeared. Analysis of RR-interval variability could not detect major alterations in autonomic function in CFS.

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Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

Clinical Science ◽

10.1042/cs19990155 ◽

1999 ◽

Vol 97 (3) ◽

pp. 319 ◽

Cited By ~ 1

Author(s):

D.A. DUPREZ ◽

M.L. DE BUYZERE ◽

B. DRIEGHE ◽

F. VANHAVERBEKE ◽

Y. TAES ◽

...

Keyword(s):

Blood Pressure ◽

Chronic Fatigue Syndrome ◽

Chronic Fatigue ◽

Short Term ◽

Fatigue Syndrome

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Post-Exertional Malaise May Be Related to Central Blood Pressure, Sympathetic Activity and Mental Fatigue in Chronic Fatigue Syndrome Patients

Journal of Clinical Medicine ◽

10.3390/jcm10112327 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2327

Author(s):

Sławomir Kujawski ◽

Joanna Słomko ◽

Lynette Hodges ◽

Derek F. H. Pheby ◽

Modra Murovska ◽

...

Keyword(s):

Blood Pressure ◽

Nervous System ◽

Autonomic Nervous System ◽

Chronic Fatigue Syndrome ◽

Systolic Blood Pressure ◽

Sympathetic Activity ◽

Chronic Fatigue ◽

Mental Fatigue ◽

Fatigue Syndrome ◽

Central Systolic Blood Pressure

Post-exertional malaise (PEM) is regarded as the hallmark symptom in chronic fatigue syndrome (CFS). The aim of the current study is to explore differences in CFS patients with and without PEM in indicators of aortic stiffness, autonomic nervous system function, and severity of fatigue. One-hundred and one patients met the Fukuda criteria. A Chronic Fatigue Questionnaire (CFQ) and Fatigue Impact Scale (FIS) were used to assess the level of mental and physical fatigue. Aortic systolic blood pressure (sBPaortic) and the autonomic nervous system were measured with the arteriograph and Task Force Monitor, respectively. Eighty-two patients suffered prolonged PEM according to the Fukuda criteria, while 19 did not. Patients with PEM had higher FIS scores (p = 0.02), lower central systolic blood pressure (p = 0.02) and higher mental fatigue (p = 0.03). For a one-point increase in the mental fatigue component of the CFQ scale, the risk of PEM increases by 34%. For an sBPaortic increase of 1 mmHg, the risk of PEM decreases by 5%. For a one unit increase in sympathovagal balance, the risk of PEM increases by 330%. Higher mental fatigue and sympathetic activity in rest are related to an increased risk of PEM, while higher central systolic blood pressure is related to a reduced risk of PEM. However, none of the between group differences were significant after FDR correction, and therefore conclusions should be treated with caution and replicated in further studies.

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Fractal analysis and recurrence quantification analysis of heart rate and pulse transit time for diagnosing chronic fatigue syndrome

Clinical Autonomic Research ◽

10.1007/s10286-002-0044-8 ◽

2002 ◽

Vol 12 (4) ◽

pp. 264-272 ◽

Cited By ~ 26

Author(s):

Jochanan E. Naschitz ◽

Edmond Sabo ◽

Shaul Naschitz ◽

Itzhak Rosner ◽

Michael Rozenbaum ◽

...

Keyword(s):

Heart Rate ◽

Chronic Fatigue Syndrome ◽

Transit Time ◽

Fractal Analysis ◽

Pulse Transit Time ◽

Chronic Fatigue ◽

Recurrence Quantification Analysis ◽

Fatigue Syndrome ◽

Recurrence Quantification ◽

Quantification Analysis

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Reduced heart rate variability predicts fatigue severity in individuals with chronic fatigue syndrome/myalgic encephalomyelitis

Journal of Translational Medicine ◽

10.1186/s12967-019-02184-z ◽

2020 ◽

Vol 18 (1) ◽

Cited By ~ 2

Author(s):

Rosa María Escorihuela ◽

Lluís Capdevila ◽

Juan Ramos Castro ◽

María Cleofé Zaragozà ◽

Sara Maurel ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Chronic Fatigue Syndrome ◽

Frequency Domain ◽

Chronic Fatigue ◽

Myalgic Encephalomyelitis ◽

Healthy Controls ◽

Fatigue Syndrome ◽

Potential Biomarker ◽

Fatigue Severity

Abstract Background Heart rate variability (HRV) is an objective, non-invasive tool to assessing autonomic dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). People with CFS/ME tend to have lower HRV; however, in the literature there are only a few previous studies (most of them inconclusive) on their association with illness-related complaints. To address this issue, we assessed the value of different diurnal HRV parameters as potential biomarker in CFS/ME and also investigated the relationship between these HRV indices and self-reported symptoms in individuals with CFS/ME. Methods In this case–control study, 45 female patients who met the 1994 CDC/Fukuda definition for CFS/ME and 25 age- and gender-matched healthy controls underwent HRV recording-resting state tests. The intervals between consecutive heartbeats (RR) were continuously recorded over three 5-min periods. Time- and frequency-domain analyses were applied to estimate HRV variables. Demographic and clinical features, and self-reported symptom measures were also recorded. Results CFS/ME patients showed significantly higher scores in all symptom questionnaires (p < 0.001), decreased RR intervals (p < 0.01), and decreased HRV time- and frequency-domain parameters (p < 0.005), except for the LF/HF ratio than in the healthy controls. Overall, the correlation analysis reached significant associations between the questionnaires scores and HRV time- and frequency-domain measurements (p < 0.05). Furthermore, separate linear regression analyses showed significant relationships between self-reported fatigue symptoms and mean RR (p = 0.005), RMSSD (p = 0.0268) and HFnu indices (p = 0.0067) in CFS/ME patients, but not in healthy controls. Conclusions Our findings suggest that ANS dysfunction presenting as increased sympathetic hyperactivity may contribute to fatigue severity in individuals with ME/CFS. Further studies comparing short- and long-term HRV recording and self-reported outcome measures with previous studies in larger CFS/ME cohorts are urgently warranted.

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Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity

Psychological Medicine ◽

10.1017/s0033291799003189 ◽

2001 ◽

Vol 31 (1) ◽

pp. 107-114 ◽

Cited By ~ 58

Author(s):

E. BAZELMANS ◽

G. BLEIJENBERG ◽

J. W. M. VAN DER MEER ◽

H. FOLGERING

Keyword(s):

Physical Activity ◽

Heart Rate ◽

Chronic Fatigue Syndrome ◽

Physical Fitness ◽

Maximal Exercise ◽

Negative Relationship ◽

Chronic Fatigue ◽

Controlled Study ◽

Fatigue Syndrome ◽

Physical Deconditioning

Background. Chronic fatigue syndrome (CFS) patients often complain that physical exertion produces an increase of complaints, leading to a greater need for rest and more time spent in bed. It has been suggested that this is due to a bad physical fitness and that physical deconditioning is a perpetuating factor in CFS. Until now, studies on physical deconditioning in CFS have shown inconsistent results.Methods. Twenty CFS patients and 20 matched neighbourhood controls performed a maximal exercise test with incremental load. Heart rate, blood pressure, respiratory tidal volume, O2 saturation, O2 consumption, CO2 production, and blood-gas values of arterialized capillary blood were measured. Physical fitness was quantified as the difference between the actual and predicted ratios of maximal workload versus increase of heart rate. Fatigue, impairment and physical activity were assessed to study its relationship with physical fitness.Results. There were no statistically significant differences in physical fitness between CFS patients and their controls. Nine CFS patients had a better fitness than their control. A negative relationship between physical fitness and fatigue was found in both groups. For CFS patients a negative correlation between fitness and impairment and a positive correlation between fitness and physical activity was found as well. Finally, it was found that more CFS patients than controls did not achieve a physiological limitation at maximal exercise.Conclusions. Physical deconditioning does not seem a perpetuating factor in CFS.

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