SUCCINIC DEHYDROGENASE ACTIVITY AND SULPHYDRYL GROUPS IN CIRRHOSIS OF THE RAT LIVER INDUCED BY A LOW PROTEIN/HIGH FAT DIET

2009 ◽  
Vol 46 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Antti Telkkä ◽  
Johan Ahlqvist
Keyword(s):  
Dehydrogenase Activity ◽  
Rat Liver ◽  
High Fat Diet ◽  
Succinic Dehydrogenase ◽  
High Fat ◽  
Succinic Dehydrogenase Activity ◽  
Low Protein ◽  
Sulphydryl Groups

Influence of Testosterone Propionate on the Succinic Dehydrogenase Activity of Male Rat Liver

1958 ◽  
Vol 193 (1) ◽  
pp. 73-74 ◽  
Author(s):  
T. H. Rindani
Keyword(s):  
Dehydrogenase Activity ◽  
Rat Liver ◽  
Succinic Dehydrogenase ◽  
Liver Homogenate ◽  
Male Rats ◽  
Male Rat ◽  
Succinic Dehydrogenase Activity ◽  
Hormone Administration ◽  
Wet Weight ◽  
Testosterone Administration

Castration of male rats was shown previously to cause an increase of the succinic dehydrogenase activity in male rat liver homogenate. The present study was undertaken to examine if this increase was influenced by testosterone administration to the castrated animals over different periods of duration. It was observed that testosterone treatment counteracted the increase in the enzyme activity caused by castration and that this effect was more marked with longer duration of the hormone administration. Further the succinic dehydrogenase activity was not related directly to the wet weight of the liver.

scholarly journals Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Camila Lubaczeuski ◽  
Luciana Mateus Gonçalves ◽  
Jean Franciesco Vettorazzi ◽  
Mirian Ayumi Kurauti ◽  
Junia Carolina Santos-Silva ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Insulin Clearance ◽  
Protein Diet ◽  
Low Protein Diet ◽  
High Fat ◽  
Insulin Degrading Enzyme ◽  
Low Protein

The aim of this study was to investigate the effect of subdiaphragmatic vagotomy on insulin sensitivity, secretion, and degradation in metabolic programmed mice, induced by a low-protein diet early in life, followed by exposure to a high-fat diet in adulthood. Weaned 30-day-old C57Bl/6 mice were submitted to a low-protein diet (6% protein). After 4 weeks, the mice were distributed into three groups: LP group, which continued receiving a low-protein diet; LP + HF group, which started to receive a high-fat diet; and LP + HFvag group, which underwent vagotomy and also was kept at a high-fat diet. Glucose-stimulated insulin secretion (GSIS) in isolated islets, ipGTT, ipITT, in vivo insulin clearance, and liver expression of the insulin-degrading enzyme (IDE) was accessed. Vagotomy improved glucose tolerance and reduced insulin secretion but did not alter adiposity and insulin sensitivity in the LP + HFvag, compared with the LP + HF group. Improvement in glucose tolerance was accompanied by increased insulinemia, probably due to a diminished insulin clearance, as judged by the lower C-peptide : insulin ratio, during the ipGTT. Finally, vagotomy also reduced liver IDE expression in this group. In conclusion, when submitted to vagotomy, the metabolic programmed mice showed improved glucose tolerance, associated with an increase of plasma insulin concentration as a result of insulin clearance reduction, a phenomenon probably due to diminished liver IDE expression.

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