scholarly journals Rat skin wound healing induced by alternagin-C, a disintegrin-like, Cys-rich protein from Bothrops alternatus venom

2011 ◽  
Vol 8 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Estela Maria Correia Sant'Ana ◽  
Cibele Marli Cação Paiva Gouvêa ◽  
João Luiz Quagliotti Durigan ◽  
Márcia Regina Cominetti ◽  
Edson Rosa Pimentel ◽  
...  
Marine Drugs ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 48 ◽  
Author(s):  
Mei-Ling Sun ◽  
Fang Zhao ◽  
Xiu-Lan Chen ◽  
Xi-Ying Zhang ◽  
Yu-Zhong Zhang ◽  
...  

Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague–Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.


1990 ◽  
Vol 48 (1) ◽  
pp. 68-71 ◽  
Author(s):  
Isto Nordback ◽  
Rauno Kulmala ◽  
Markku Järvinen

Author(s):  
Jian‑Li Dong ◽  
Hai‑Cao Dong ◽  
Liang Yang ◽  
Zhe‑Wen Qiu ◽  
Jia Liu ◽  
...  

2014 ◽  
Author(s):  
Jing Chen ◽  
Chungen Guo ◽  
Fan Zhang ◽  
Yahao Xu ◽  
Xiaoqin Zhu ◽  
...  

1997 ◽  
Vol 137 (1) ◽  
pp. 67-77 ◽  
Author(s):  
Akiko Okada ◽  
Catherine Tomasetto ◽  
Yves Lutz ◽  
Jean-Pierre Bellocq ◽  
Marie-Christine Rio ◽  
...  

Skin wound healing depends on cell migration and extracellular matrix remodeling. Both processes, which are necessary for reepithelization and restoration of the underlying connective tissue, are believed to involve the action of extracellular proteinases. We screened cDNA libraries and we found that six matrix metalloproteinase genes were highly expressed during rat skin wound healing. They were namely those of stromelysin 1, stromelysin 3, collagenase 3, gelatinase A (GelA), gelatinase B, and membrane type-1 matrix metalloproteinase (MT1-MMP). The expression kinetics of these MMP genes, the tissue distribution of their transcripts, the results of cotransfection experiments in COS-1 cells, and zymographic analyses performed using microdissected rat wound tissues support the possibility that during cutaneous wound healing pro-GelA and pro-gelatinase B are activated by MT1-MMP and stromelysin 1, respectively. Since MT1-MMP has been demonstrated to be a membrane-associated protein (Sato, H., T. Takino, Y. Okada, J. Cao, A. Shinagawa, E. Yamamoto, and M. Seiki. 1994. Nature (Lond.). 370: 61–65), our finding that GelA and MT1-MMP transcripts were expressed in stromal cells exhibiting a similar tissue distribution suggests that MT1-MMP activates pro-GelA at the stromal cell surface. This possibility is further supported by our observation that the processing of proGelA to its mature form correlated to the detection of MT1-MMP in cell membranes of rat fibroblasts expressing the MT1-MMP and GelA genes. These observations, together with the detection of high levels of the mature GelA form in the granulation tissue but not in the regenerating epidermis, suggest that MT1-MMP and GelA contribute to the restoration of connective tissue during rat skin wound healing.


2013 ◽  
Vol 76 (11) ◽  
pp. 2047-2053 ◽  
Author(s):  
Raquel Costa ◽  
Rita Negrão ◽  
Inês Valente ◽  
Ângela Castela ◽  
Delfim Duarte ◽  
...  

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