scholarly journals Absence of Adverse Effects of Oseltamivir on Sleep: A Double-Blind, Randomized Study in Healthy Volunteers in Japan

2011 ◽  
Vol 109 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Naohisa Uchimura ◽  
Hiroo Kuwahara ◽  
Yuji Kumagai ◽  
Kazuo Mishima ◽  
Yuichi Inoue ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Healthy Volunteers ◽  
Randomized Study ◽  
Double Blind

scholarly journals Oxycodone reduced postoperative catheter-related bladder discomfort undergoing transurethral resection prostate. A prospective, double -blind randomized study

2020 ◽  
Author(s):  
jian li
Keyword(s):  
Adverse Effects ◽  
Visceral Pain ◽  
Randomized Study ◽  
Control Group ◽  
Trial Registry ◽  
Clinical Trial Registry ◽  
Double Blind ◽  
Unique Effect ◽  
Vas Scores ◽  
Opium Alkaloid

Abstract Background: Catheter-related bladder discomfort (CRBD) is a common and distressing complication that often occurs caused by urinary bladder catheterization and urethral mucosa injury postoperatively. Oxycodone is a semi-synthetic opioids prepared from opium alkaloid the baine plant derivative. Its μ and κ dual-receptor agonism has a unique effect in the treatment of visceral pain. The aim of this study to observe the efficacy of oxycodone for the treatment of CRBD undergo trans-urethral resection prostate (TURP). Methods: Patients with ASA I-III received trans-urethral resection prostate under general anesthesia were enrolled. Patients who complained CRBD were randomized allocated to the control group (n=42) received placebo and the observed group (n=41) received 0.03mg/kg of oxycodone. The severity of CRBD assessed by NRS were assessed at 0, 5min, 1/2h, and 2h after administration of the study agents. VAS scores were used to assess pain intensity during the same period. Postoperative PCA analgesic sufentanil dose during of PACU times and the incidences of agitation, nausea, vomiting, dizziness, over sedation were recorded in these patients. Results: Compared with the control group, the incidence of CRBD was significantly lower in the oxycodone group at 5min and 1/2h. Compared with the controlled group, VAS scores and incidences of agitation were lower in oxycodone group and significantly decreased sufentanil dosage within 6h (P<0.01). There were no significant differences in the incidence of postoperative adverse effects and during of PACU between two groups(P＜0.05). Conclusion: Oxycodone 0.03mg/kg effectively reduced patients with CRBD after TURP without incurring serious adverse effects.Trial registration: Chinese Clinical Trial Registry, ChiCTR-IPR-16008814.

Ex Vivo Inhibition of Platelet Aggregation in Patients with Severe Limb Arteriopathy Treated with BAY U3405, a Specific IX A2 Receptor Antagonist

1994 ◽  
Vol 72 (05) ◽  
pp. 659-662 ◽  
Author(s):  
S Bellucci ◽  
W Kedra ◽  
H Groussin ◽  
N Jaillet ◽  
P Molho-Sabatier ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Ex Vivo ◽  
Randomized Study ◽  
In Vivo Studies ◽  
Walking Distance ◽  
Peripheral Blood Flow ◽  
Walking Ability ◽  
Double Blind ◽  
Platelet Factor

SummaryA double-blind, placebo-controlled randomized study with BAY U3405, a specific thromboxane A2 (TX A2) receptor blocker, was performed in patients suffering from severe stade II limb arteriopathy. BAY U3405 or placebo was administered in 16 patients at 20 mg four times a day (from day 1 to day 3). Hemostatic studies were done before therapy, and on day 2 and day 3 under therapy. On day 3, BAY U3405 was shown to induce a highly statistically significant decrease of the velocity and the intensity of the aggregations mediated by arachidonic acid (56 ± 37% for the velocity, 58 ± 26% for the intensity) or by U46619 endoperoxide analogue (36 ± 35% for the velocity, 37 ± 27% for the intensity). Similar results were already observed on day 2. By contrast, such a decrease was not noticed with ADP mediated platelet aggregation. Furthermore, plasma levels of betathrombo-globulin and platelet factor 4 remained unchanged. Peripheral hemodynamic parameters were also studied. The peripheral blood flow was measured using a Doppler ultrasound; the pain free walking distance and the total walking ability distance were determined under standardized conditions on a treadmill. These last two parameters show a trend to improvement which nevertheless was not statistically significant. All together these results encourage further in vivo studies using BAY U3405 or related compounds on a long-term administration.

Effects of Neurapas® balance on sleep EEG, cognitive performance and mood: A double-blind randomised cross-over study in healthy volunteers

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
M Giesler ◽  
A Thum ◽  
A Haag ◽  
A Wartenberg-Demandt ◽  
G McGregor ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Cognitive Performance ◽  
Sleep Eeg ◽  
Double Blind

To Compare the Insertion Conditions For I-Gel, Using Propofol, Thiopentone and Thiopentone With Topical Lignocaine Spray. - A Double Blind Randomized Study

2011 ◽  
Vol 4 (2) ◽  
pp. 14-16
Author(s):  
DR .SUHAS RAMASWAMY ◽  
◽  
DR.SAROJA SHARMA ◽  
DR.SAURAB MOHAN ◽  
DR.MADHUSUDAN UPADYA ◽  
...  
Keyword(s):  
Randomized Study ◽  
Double Blind
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