INDUCTION OF APOPTOSIS BY GINSENG SAPONIN METABOLITE IN U937 HUMAN MONOCYTIC LEUKEMIA CELLS

2005 ◽  
Vol 29 (1) ◽  
pp. 27-40 ◽  
Author(s):  
KYOUNG AH KANG ◽  
HEE KYOUNG LIM ◽  
SEUNG UK KIM ◽  
YEONG WAN KIM ◽  
WON TAEK KIM ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Monocytic Leukemia ◽  
Ginseng Saponin ◽  
Induction Of Apoptosis ◽  
Human Monocytic Leukemia

Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite

2006 ◽  
Vol 11 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Kyoung Ah Kang ◽  
Kyoung Hwa Lee ◽  
Sungwook Chae ◽  
Jeong Ki Kim ◽  
Jung Yeon Seo ◽  
...  
Keyword(s):  
Telomerase Activity ◽  
Leukemia Cells ◽  
Compound K ◽  
Monocytic Leukemia ◽  
Ginseng Saponin ◽  
Human Monocytic Leukemia

scholarly journals Flavonoid 4′-O-Methylkuwanon E fromMorus albaInduces the Differentiation of THP-1 Human Leukemia Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Peter Kollar ◽  
Tomáš Bárta ◽  
Stanislava Keltošová ◽  
Pavlína Trnová ◽  
Veronika Müller Závalová ◽  
...  
Keyword(s):  
Surface Antigen ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Monocytic Differentiation ◽  
Monocytic Leukemia ◽  
Nbt Reduction ◽  
Dependent Growth ◽  
White Mulberry ◽  
Cell Growth And Viability ◽  
Human Monocytic Leukemia

Aims. In this work we studied cytodifferentiation effects of newly characterized prenyl flavonoid 4′-O-methylkuwanon E (4ME) isolated from white mulberry (Morus albaL.).Main Methods. Cell growth and viability were measured by dye exclusion assay; cell cycle and surface antigen CD11b were monitored by flow cytometry. For the cytodifferentiation of cells the NBT reduction assay was employed. Regulatory proteins were assessed by western blotting.Key Findings. 4ME induced dose-dependent growth inhibition of THP-1 cells, which was not accompanied by toxic effect. Inhibition of cells proliferation caused by 4ME was associated with the accumulation in G1 phase and with downregulation of hyperphosphorylated pRb. Treatment with 4ME led to significant induction of NBT-reducing activity of PMA stimulated THP-1 cells and upregulation expression of differentiation-associated surface antigen CD11b. Our results suggest that monocytic differentiation induced by 4ME is connected with up-regulation of p38 kinase activity.Significance. Our study provides the first evidence that 4ME induces the differentiation of THP-1 human monocytic leukemia cells and thus is a potential cytodifferentiating anticancer agent.

Selective activation of NF-κB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells

2008 ◽  
Vol 22 (2) ◽  
pp. 136-146 ◽  
Author(s):  
Megumi Yamamoto ◽  
Seishiro Hirano ◽  
Christoph F. A. Vogel ◽  
Xing Cui ◽  
Fumio Matsumura
Keyword(s):  
Leukemia Cells ◽  
Monocytic Leukemia ◽  
Selective Activation ◽  
Low Concentration ◽  
Human Monocytic Leukemia

scholarly journals Induction of fibroblast proliferation by interleukin-1 derived from human monocytic leukemia cells

1984 ◽  
Vol 27 (9) ◽  
pp. 995-1001 ◽  
Author(s):  
Arnold E. Postlethwaite ◽  
Lawrence B. Lachman ◽  
Andrew H. Kang
Keyword(s):  
Interleukin 1 ◽  
Leukemia Cells ◽  
Fibroblast Proliferation ◽  
Monocytic Leukemia ◽  
Human Monocytic Leukemia

scholarly journals Pathways related to PMA-differentiated THP1 human monocytic leukemia cells revealed by RNA-Seq

2015 ◽  
Vol 58 (12) ◽  
pp. 1282-1287 ◽  
Author(s):  
ChengWu Zeng ◽  
WenTao Wang ◽  
XiBao Yu ◽  
LiJian Yang ◽  
ShaoHua Chen ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Rna Seq ◽  
Monocytic Leukemia ◽  
Human Monocytic Leukemia
Sign in / Sign up

Export Citation Format

Share Document