scholarly journals Profiling of Differentially Expressed Genes in LRRC4 Overexpressed Glioblastoma Cells by cDNA Array

2005 ◽  
Vol 37 (10) ◽  
pp. 680-687 ◽  
Author(s):  
Qiu-Hong Zhang ◽  
Ming-Hua Wu ◽  
Li-Li Wang ◽  
Li Cao ◽  
Ke Tang ◽  
...  
Keyword(s):  
Tumor Invasion ◽  
Cell Cycle Progression ◽  
Cdna Array ◽  
Normal Function ◽  
Glioblastoma Cells ◽  
Array Analysis ◽  
Cycle Progression ◽  
Altered Expression ◽  
The Central Nervous System ◽  
Overexpressing Cell

Abstract Our previous study has shown that LRRC4 is a novel member of the leucine-rich repeat (LRR) superfamily and has the potential to suppress brain tumor growth. In order to further analyze the functions of LRRC4 on the maintenance of normal function and suppression of tumorigenesis in the central nervous system, we investigated alterations in gene expression related to neurobiology by the Atlas array in two inducible dual-stable LRRC4-overexpressing cell lines. Seventeen of 588 genes spotted on the Atlas membrane showed altered expression levels in LRRC4 transfected U251MG Tet-on cells, which are involved in cell proliferation and cell cycle progression, tumor invasion and metastasis, and neurotransmitter synthesis and release. In addition, cell invasion assay results showed that LRRC4 can inhibit the U251MG cell migration. These studies represent the first cDNA array analysis of the effects of LRRC4 on the involvement of different neurobiological genes in U251MG glioblastoma cells and provide new insights into the function of LRRC4 in glioma.

scholarly journals PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells

2016 ◽  
Vol 139 (1) ◽  
pp. 99-111 ◽  
Author(s):  
Joydeep Mukherjee ◽  
Shigeo Ohba ◽  
Wendy L. See ◽  
Joanna J. Phillips ◽  
Annette M. Molinaro ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Glioblastoma Cells ◽  
Cycle Progression ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

Altered expression of mitochondrial related genes in the native Tibetan placents by mitochondrial cDNA array analysis

2009 ◽  
Vol 24 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Yongjun Luo ◽  
Wenxiang Gao ◽  
Xiuxin Zhao ◽  
Lang Suo ◽  
Li Chen ◽  
...  
Keyword(s):  
Cdna Array ◽  
Array Analysis ◽  
Altered Expression

scholarly journals Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression.

1997 ◽  
Vol 17 (6) ◽  
pp. 3323-3334 ◽  
Author(s):  
Y Cao ◽  
B R Cairns ◽  
R D Kornberg ◽  
B C Laurent
Keyword(s):  
Cell Cycle ◽  
Chromatin Remodeling ◽  
Cell Cycle Progression ◽  
Normal Function ◽  
Temperature Sensitive ◽  
Cycle Progression ◽  
Conserved Domain ◽  
Chromatin Remodeling Complex ◽  
Evolutionarily Conserved ◽  
M Phase

Several eukaryotic multiprotein complexes, including the Saccharomyces cerevisiae Snf/Swi complex, remodel chromatin for transcription. In contrast to the Snf/Swi proteins, Sfh1p, a new Snf5p paralog, is essential for viability. The evolutionarily conserved domain of Sfh1p is sufficient for normal function, and Sfh1p interacts functionally and physically with an essential Snf2p paralog in a novel nucleosome-restructuring complex called RSC (for remodels the structure of chromatin). A temperature-sensitive sfh1 allele arrests cells in the G2/M phase of the cell cycle, and the Sfh1 protein is specifically phosphorylated in the G1 phase. Together, these results demonstrate a link between chromatin remodeling and progression through the cell division cycle, providing genetic clues to possible targets for RSC function.

scholarly journals M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells

2013 ◽  
Vol 17 (4) ◽  
pp. 552-566 ◽  
Author(s):  
Michela Ferretti ◽  
Cinzia Fabbiano ◽  
Maria Di Bari ◽  
Claudia Conte ◽  
Emilia Castigli ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Receptor Activation ◽  
Glioblastoma Cells ◽  
Cycle Progression ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals NDRG4 Is Required for Cell Cycle Progression and Survival in Glioblastoma Cells

2009 ◽  
Vol 284 (37) ◽  
pp. 25160-25169 ◽  
Author(s):  
Stephen H. Schilling ◽  
Anita B. Hjelmeland ◽  
Daniel R. Radiloff ◽  
Irwin M. Liu ◽  
Timothy P. Wakeman ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Glioblastoma Cells ◽  
Cycle Progression

DOXORUBICIN EFFECT ON CELL CYCLE PROGRESSION OF MDR RAT GLIOBLASTOMA CELLS AND PARENTAL CELLS

1993 ◽  
Vol 79 (3) ◽  
pp. 276-276
Author(s):  
Sylvie Huet ◽  
Philippe Lagarde ◽  
Jacques Robert ◽  
Norbert Gualde
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Glioblastoma Cells ◽  
Cycle Progression

Drosophilap27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression

Development ◽  
2002 ◽  
Vol 129 (2) ◽  
pp. 319-328 ◽  
Author(s):  
Claas A. Meyer ◽  
Ina Kramer ◽  
Rainer Dittrich ◽  
Sandra Marzodko ◽  
Jan Emmerich ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Progression ◽  
Regulatory Region ◽  
Regulatory Elements ◽  
Cycle Progression ◽  
The Central Nervous System ◽  
Mother Cells ◽  
Epidermal Expression ◽  
Epidermal Cell Proliferation

dacapo encodes a CIP/KIP-type inhibitor of Cyclin E/Cdk2 complexes in Drosophila melanogaster. In the embryonic epidermis, dacapo expression starts during G2 of the final division cycle and is required for the arrest of cell cycle progression in G1 after the final mitosis. The onset of dacapo transcription is the earliest event known to be required for the epidermal cell proliferation arrest. To advance our understanding of the regulatory mechanisms that terminate cell proliferation at the appropriate stage, we have analyzed the control of dacapo transcription. We show that dacapo transcription is not coupled to cell cycle progression. It is not affected in mutants where proliferation is arrested either too early or too late. Moreover, upregulation of dacapo expression is not an obligatory event of the cell cycle exit process. During early development of the central nervous system, we cannot detect p27Dacapo during the final division cycle of ganglion mother cells, while it is expressed at later stages. The control of dacapo expression therefore varies in different stages and tissues. The dacapo regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation.

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